Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Small, Год журнала: 2022, Номер 19(6)

Опубликована: Дек. 5, 2022

Abstract Bacterial biofilm‐related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is low permeability enrichment therapeutic agents within biofilm, which results from particular features matrix barriers such as negatively charged components highly viscous compact EPS structures. Hence, developing novel strategies enhanced penetrability crucial. Herein, current progress nanotechnology methods to improve agents’ against matrix, regulating material morphology surface properties, utilizing physical penetration nano/micromotors microneedle patches, equipping nanoparticles degradation enzymes signal molecules, first summarized. Finally, challenges, perspectives, future implementations engineered delivery systems manage infections presented in detail.

Язык: Английский

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Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing

National Science Review, Год журнала: 2024, Номер 11(4)

Опубликована: Янв. 29, 2024

ABSTRACT There is still an urgent need to develop hydrogels with intelligent antibacterial ability achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy hydrogel dressing bacteria-responsive self-activating property multiple nanozyme activities remodel microenvironment in order significantly promote healing. Specifically, pH-responsive H2O2 self-supplying composite (MSCO) pH/enzyme-sensitive triblock micelles encapsulated lactate oxidase (PPEL) were prepared composed L-arginine-modified chitosan (CA) phenylboronic acid-modified oxidized dextran (ODP) form cascade platform. The respond multifactorial changes bacterial metabolic biofilm eradication through transformation metabolites, chemodynamic therapy enhanced activity conjunction self-driven nitric oxide (NO) release. showed ‘self-diagnostic’ for Through infection stage self-adaptive oxidative stress relief angiogenesis post-infection stage, it promotes closure, accelerates collagen deposition angiogenesis, completely improves regeneration, which provides new method design dressings.

Язык: Английский

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Nanomaterials for photothermal cancer therapy

RSC Advances, Год журнала: 2023, Номер 13(21), С. 14443 - 14460

Опубликована: Янв. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Язык: Английский

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Advances in Nanotechnology for Biofilm Inhibition

ACS Omega, Год журнала: 2023, Номер 8(24), С. 21391 - 21409

Опубликована: Июнь 7, 2023

Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible range multidrug-resistant pathogens. These pathogens show reduced susceptibility intracellular survival. However, current methods for treating biofilms, such smart materials targeted drug delivery systems, not been found effective in preventing biofilm formation. To address this challenge, nanotechnology provided innovative solutions formation by clinically relevant Recent advances nanotechnological strategies, including metallic nanoparticles, functionalized dendrimers, polymeric cyclodextrin-based delivery, solid lipid polymer conjugates, liposomes, may provide valuable technological against infectious diseases. Therefore, it is imperative conduct comprehensive review summarize the recent advancements limitations advanced nanotechnologies. present Review encompasses summary agents, mechanisms that lead formation, impact on human health. In nutshell, offers survey managing infections. A detailed presentation how these strategies improve control prevent key objective mechanisms, applications, prospects nanotechnologies better understanding

Язык: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Год журнала: 2023, Номер 4(2)

Опубликована: Окт. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Язык: Английский

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100559 - 100559

Опубликована: Янв. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Язык: Английский

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A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria

Advanced Functional Materials, Год журнала: 2023, Номер 33(37)

Опубликована: Май 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Язык: Английский

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Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)

Опубликована: Май 15, 2023

Abstract The application of medical implants has greatly improved the survival rate and life quality patients. Nevertheless, in recent years, there are increasing cases implant dysfunction or failure because bacterial infections. Despite significant improvements biomedicine, still serious challenges treatment implant‐related With formation biofilms development resistance, these limitations lead to a low efficacy conventional antibiotics. To address challenges, it is urgent exploit innovative strategies for Based on ideas, environment‐responsive therapeutic platforms with high selectivity, drug minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, antibacterial activity therapeutics can be activated demand exhibit remarkable effects. Exogenous stimuli include photo, magnetism, microwave, ultrasound. Endogenous mainly pathological characteristics infections such as acidic pH, anomalous temperature, abnormal enzymatic activities. In this review, progress spatiotemporally controlled release/activation systematically summarized. Afterward, opportunities emerging highlighted. Finally, hoped that review will offer novel ideas techniques combat

Язык: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(29), С. 6746 - 6761

Опубликована: Янв. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Язык: Английский

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Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives

Acta Biomaterialia, Год журнала: 2024, Номер 177, С. 1 - 19

Опубликована: Фев. 7, 2024

Язык: Английский

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