European Polymer Journal, Год журнала: 2024, Номер unknown, С. 113608 - 113608
Опубликована: Ноя. 1, 2024
Язык: Английский
Materials Horizons, Год журнала: 2023, Номер 10(9), С. 3507 - 3522
Опубликована: Янв. 1, 2023
Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage due limited self-regeneration capacity such defects. Herein, novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) bone marrow-derived stem cells (BMSCs) was designed constructed via enzymatic reaction fibrinogen thrombin. Meanwhile, thioketal (TK)-based liposome synthesized load chondrogenesis-inducing factor KGN, bioenzyme thrombin an ultrasound-sensitive agent PpIX. Under ultrasound stimulation, TK-based destroyed, followed gelation Moreover, sustained release KGN realized regulating conditions. Importantly, ROS generation within microenvironment fibrin significantly promoted chondrogenic differentiation BMSCs Smad5/mTOR signalling pathway effectively improved regeneration rat defect model. Overall, ROS-controlled drug has potential for efficient repair.
Язык: Английский
Процитировано
45
Advanced Materials, Год журнала: 2023, Номер 36(1)
Опубликована: Окт. 21, 2023
Abstract Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced patients. However, immune‐related adverse events caused by also bring heavy burden Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic sonodynamic therapy. In addition, SPNs work functional nanocarrier synergize variety of immunomodulators amplify anti‐tumor immune responses. this review, SPNs‐based combination is comprehensively summarized according the SPNs’ modalities type loaded immunomodulators. The in‐depth understanding existing will hopefully inspire design more novel nanomaterials potent effects, ultimately promote their clinical translation.
Язык: Английский
Процитировано
44
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Язык: Английский
Процитировано
42
Biomaterials, Год журнала: 2023, Номер 305, С. 122455 - 122455
Опубликована: Дек. 27, 2023
Язык: Английский
Процитировано
37
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 7, 2024
Immune checkpoint blockade (ICB) immunotherapy remains hampered by insufficient immunogenicity and a high-lactate immunosuppressive tumor microenvironment (TME). Herein, nanobody-engineered NIR-II nanoadjuvant with targeting metabolic reprogramming capability is constructed for potentiating photothermal-ferroptosis immunotherapy. Specifically, the (2DG@FS-Nb) prepared metallic iron ion-mediated coordination self-assembly of D-A-D type molecules loading glycolysis inhibitor, 2-deoxy-D-glucose (2DG), followed modification aPD-L1 nanobody (Nb), which can effectively target TME trigger in situ immune blockade. The nanoadjuvants responsively release therapeutic components acidic TME, enabling precise location fluorescence/photoacoustic imaging while initiating therapy. remarkable photothermal efficiency elevated glutathione (GSH) depletion further sensitize ferroptosis to induce severe lipid peroxidation, provoking robust immunogenic cell death (ICD) anti-tumor response. Importantly, released 2DG markedly inhibits lactate generation through obstruction. Decreased efflux remodels suppressing M2 macrophage proliferation downregulating regulatory T levels. This work provides new paradigm integration phototheranostics metabolism regulation into single nanoplatform amplified combined ICB
Язык: Английский
Процитировано
10
Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216608 - 216608
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
1
Nano Today, Год журнала: 2024, Номер 57, С. 102398 - 102398
Опубликована: Июль 12, 2024
Язык: Английский
Процитировано
9
Materials Horizons, Год журнала: 2024, Номер 11(10), С. 2406 - 2419
Опубликована: Янв. 1, 2024
Enzymes provide a class of potential options to treat cancer, while the precise regulation enzyme activities for effective and safe therapeutic actions has been poorly reported. Dual-enzyme decorated semiconducting polymer nanoagents second near-infrared (NIR-II) photoactivatable ferroptosis-immunotherapy are reported in this study. Such (termed SPHGA) consist hemoglobin (Hb)-based (SP@Hb), adenosine deaminase (ADA) glucose oxidase (GOx) with loadings thermal-responsive nanoparticle shell. NIR-II photoactivation SPHGA results generation heat trigger on-demand releases two enzymes (ADA GOx) via destroying shells. In tumor microenvironment, GOx oxidizes form hydrogen peroxide (H2O2), which promotes Fenton reaction iron SP@Hb, resulting an enhanced ferroptosis effect immunogenic cell death (ICD). addition, ADA degrades high-level reverse immunosuppressive thus amplifying antitumor immune responses. Via ferroptosis-immunotherapy, shows improved absolutely remove bilateral tumors effectively suppress metastases subcutaneous 4T1 breast cancer models. This study presents dual-enzyme-based nanoagent controllable therapy.
Язык: Английский
Процитировано
8
Nano Today, Год журнала: 2024, Номер 56, С. 102286 - 102286
Опубликована: Май 6, 2024
Язык: Английский
Процитировано
8
Coordination Chemistry Reviews, Год журнала: 2024, Номер 515, С. 215921 - 215921
Опубликована: Май 21, 2024
Nitric oxide (NO) is an important biochemical molecule that endogenously produced to act for instance as neurotransmitter, effect cell growth, or regulate the immune response. Therapeutic treatment with exogeneous NO difficult owing its gaseous and reactive nature and, not surprising, specific molecules deliver have been developed. Amongst various triggers deliberately release from these NO-releasing molecules, light most elegant allows a high degree of control over time location NO-release. For therapeutic applications, it necessary use long-wavelength light, preferably in red near infrared region, which challenging achieve. This review gives overview on approaches red-shift activation wavelength light-activated NO-release nitrosoamines, o-substituted nitroarenes, L-arginine, cupferron, nitrosyl metal complexes. While focusing single photon excitation events, direct mechanisms are covered well photoelectron transfer, energy chemiluminescence photothermal light-triggered oxidation pathways. each NO-releaser class, photochemical mechanism discussed, biological applications mentioned.
Язык: Английский
Процитировано
8