Configuration‐Mediated Efficient Non‐Radiative Transition for R848‐Assisted Photothermal Immunotherapy to Inhibit Tumor Growth and Metastasis by An In Situ Tumor Vaccine Strategy DOI
Jianan Dai, Laiping Fang, Xuan Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as safe and potent therapeutic approach, demonstrating capability suppress tumor growth metastasis. While researchers have extensively investigated various structural modifications enhance photothermal conversion performance, influence of molecular configuration received comparatively limited attention. In this study, we synthesized two isomers, CZTBT LVTBT, which possessed distinct configurations. characterized by flatter configuration, exhibited an extended absorption wavelength higher molar extinction coefficient. Its excited state facilitated stronger rotation for non‐radiative transitions, leading high efficiency (PCE) 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)‐mediated functioned situ vaccine, promoting maturation dendritic cells (DCs), T cell infiltration, differentiation natural killer (NK) memory cells, thereby activating strong immune response. Consequently, it significantly inhibited both primary distant tumors, while also limiting lung summary, study proposed configuration‐mediated transition strategy efficient immunotherapy, advancing frontiers organic agents (OPTAs) design synthesis.

Language: Английский

Emerging nitric oxide gas‐assisted cancer photothermal treatment DOI Creative Commons
Shuang Liang, Yufei Liu,

Hongquan Zhu

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

Citations

40
Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair DOI

Shunli Wu,

Hao Zhang,

Sicheng Wang

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(9), P. 3507 - 3522

Published: Jan. 1, 2023

Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage due limited self-regeneration capacity such defects. Herein, novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) bone marrow-derived stem cells (BMSCs) was designed constructed via enzymatic reaction fibrinogen thrombin. Meanwhile, thioketal (TK)-based liposome synthesized load chondrogenesis-inducing factor KGN, bioenzyme thrombin an ultrasound-sensitive agent PpIX. Under ultrasound stimulation, TK-based destroyed, followed gelation Moreover, sustained release KGN realized regulating conditions. Importantly, ROS generation within microenvironment fibrin significantly promoted chondrogenic differentiation BMSCs Smad5/mTOR signalling pathway effectively improved regeneration rat defect model. Overall, ROS-controlled drug has potential for efficient repair.

Language: Английский

Citations

42
Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy DOI
Jiayan Wu, Kanyi Pu

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Oct. 21, 2023

Abstract Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced patients. However, immune‐related adverse events caused by also bring heavy burden Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic sonodynamic therapy. In addition, SPNs work functional nanocarrier synergize variety of immunomodulators amplify anti‐tumor immune responses. this review, SPNs‐based combination is comprehensively summarized according the SPNs’ modalities type loaded immunomodulators. The in‐depth understanding existing will hopefully inspire design more novel nanomaterials potent effects, ultimately promote their clinical translation.

Language: Английский

Citations

42
A biomimetic cuproptosis amplifier for targeted NIR-II fluorescence/photoacoustic imaging-guided synergistic NIR-II photothermal immunotherapy DOI

Yeneng Dai,

Lipeng Zhu, Xue Li

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122455 - 122455

Published: Dec. 27, 2023

Language: Английский

Citations

36
Metal‐Coordinated NIR‐II Nanoadjuvants with Nanobody Conjugation for Potentiating Immunotherapy by Tumor Metabolism Reprogramming DOI Creative Commons

Yeneng Dai,

Ziang Guo, Dongliang Leng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 7, 2024

Immune checkpoint blockade (ICB) immunotherapy remains hampered by insufficient immunogenicity and a high-lactate immunosuppressive tumor microenvironment (TME). Herein, nanobody-engineered NIR-II nanoadjuvant with targeting metabolic reprogramming capability is constructed for potentiating photothermal-ferroptosis immunotherapy. Specifically, the (2DG@FS-Nb) prepared metallic iron ion-mediated coordination self-assembly of D-A-D type molecules loading glycolysis inhibitor, 2-deoxy-D-glucose (2DG), followed modification aPD-L1 nanobody (Nb), which can effectively target TME trigger in situ immune blockade. The nanoadjuvants responsively release therapeutic components acidic TME, enabling precise location fluorescence/photoacoustic imaging while initiating therapy. remarkable photothermal efficiency elevated glutathione (GSH) depletion further sensitize ferroptosis to induce severe lipid peroxidation, provoking robust immunogenic cell death (ICD) anti-tumor response. Importantly, released 2DG markedly inhibits lactate generation through obstruction. Decreased efflux remodels suppressing M2 macrophage proliferation downregulating regulatory T levels. This work provides new paradigm integration phototheranostics metabolism regulation into single nanoplatform amplified combined ICB

Language: Английский

Citations

9
Activatable Semiconducting Polymer Nanoinducers Amplify Oxidative Damage via Sono-Ferroptosis for Synergistic Therapy of Bone Metastasis DOI
Yijing Zhang, Qin Zhang,

Fengshuo Wang

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(16), P. 7699 - 7708

Published: Aug. 11, 2023

Bone metastases are secondary malignant tumors that commonly occur after the spread of advanced cancer cells. We herein report activatable semiconducting polymer nanoinducers (ASPNFP) can amplify oxidative damage via sono-ferroptosis for bone metastasis treatment. ASPNFP constructed by encapsulating plasma amine oxidase-based nanoparticles (SPNP) and Fe3O4 into singlet oxygen (1O2)-responsive nanocarriers. generate 1O2 under ultrasound (US) irradiation a sonodynamic effect to destroy stability 1O2-responsive nanocarriers, allowing US-triggered releases SPNP nanoparticles. decompose polyamines in tumor cells produce acrolein hydrogen peroxide (H2O2), which H2O2 promotes Fenton reaction mediated inducing enhanced ferroptosis generation hydroxyl radicals (•OH). The generated acrolein, 1O2, •OH simultaneously damage. thus mediate an amplified inhibit growth restrict metastasis.

Language: Английский

Citations

17
Dual-enzyme decorated semiconducting polymer nanoagents for second near-infrared photoactivatable ferroptosis-immunotherapy DOI
Yue Liu, Renjie Lu, Meng Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(10), P. 2406 - 2419

Published: Jan. 1, 2024

Enzymes provide a class of potential options to treat cancer, while the precise regulation enzyme activities for effective and safe therapeutic actions has been poorly reported. Dual-enzyme decorated semiconducting polymer nanoagents second near-infrared (NIR-II) photoactivatable ferroptosis-immunotherapy are reported in this study. Such (termed SPHGA) consist hemoglobin (Hb)-based (SP@Hb), adenosine deaminase (ADA) glucose oxidase (GOx) with loadings thermal-responsive nanoparticle shell. NIR-II photoactivation SPHGA results generation heat trigger on-demand releases two enzymes (ADA GOx) via destroying shells. In tumor microenvironment, GOx oxidizes form hydrogen peroxide (H2O2), which promotes Fenton reaction iron SP@Hb, resulting an enhanced ferroptosis effect immunogenic cell death (ICD). addition, ADA degrades high-level reverse immunosuppressive thus amplifying antitumor immune responses. Via ferroptosis-immunotherapy, shows improved absolutely remove bilateral tumors effectively suppress metastases subcutaneous 4T1 breast cancer models. This study presents dual-enzyme-based nanoagent controllable therapy.

Language: Английский

Citations

8
Neutrophil-based Trojan horse containing polymer nano-therapeutics for sono-activatable ferroptosis-immunotherapy of orthotopic glioma DOI

Mengbin Ding,

Anni Zhu,

Yijing Zhang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102398 - 102398

Published: July 12, 2024

Language: Английский

Citations

8
Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances DOI

Gaoli Niu,

Hong Wang, Yanhong Zhai

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286

Published: May 6, 2024

Language: Английский

Citations

7
Direct and indirect approaches to red-shift photoactivated nitric oxide release DOI Creative Commons
Hani M. Elbeheiry, Martin Schulz

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 515, P. 215921 - 215921

Published: May 21, 2024

Nitric oxide (NO) is an important biochemical molecule that endogenously produced to act for instance as neurotransmitter, effect cell growth, or regulate the immune response. Therapeutic treatment with exogeneous NO difficult owing its gaseous and reactive nature and, not surprising, specific molecules deliver have been developed. Amongst various triggers deliberately release from these NO-releasing molecules, light most elegant allows a high degree of control over time location NO-release. For therapeutic applications, it necessary use long-wavelength light, preferably in red near infrared region, which challenging achieve. This review gives overview on approaches red-shift activation wavelength light-activated NO-release nitrosoamines, o-substituted nitroarenes, L-arginine, cupferron, nitrosyl metal complexes. While focusing single photon excitation events, direct mechanisms are covered well photoelectron transfer, energy chemiluminescence photothermal light-triggered oxidation pathways. each NO-releaser class, photochemical mechanism discussed, biological applications mentioned.

Language: Английский

Citations

6