Idiopathic Generalized Epilepsy

Neurology, Год журнала: 2023, Номер 102(3)

Опубликована: Дек. 28, 2023

The idiopathic generalized epilepsies (IGE) make up a fifth of all epilepsies, but <1% epilepsy research. This skew reflects misperceptions: diagnosis is straightforward, pathophysiology understood, seizures are easily controlled, outgrown, morbidity and mortality low, surgical interventions impossible. Emerging evidence reveals that patients with IGE may go undiagnosed or misdiagnosed focal if EEG semiology have asymmetric features. Genetic, electrophysiologic, neuroimaging studies provide insights into pathophysiology, including overlaps differences from epilepsies. can begin in adulthood chronic drug-resistant seizures. Neuromodulatory for emerging. Rates psychiatric other comorbidities, sudden unexpected death epilepsy, parallel those epilepsy. an understudied spectrum which our diagnostic sensitivity specificity, scientific understanding, therapies remain inadequate.

Язык: Английский

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Translating Molecular Approaches to Oligodendrocyte-Mediated Neurological Circuit Modulation

Brain Sciences, Год журнала: 2024, Номер 14(7), С. 648 - 648

Опубликована: Июнь 27, 2024

The central nervous system (CNS) exhibits remarkable adaptability throughout life, enabled by intricate interactions between neurons and glial cells, in particular, oligodendrocytes (OLs) oligodendrocyte precursor cells (OPCs). This is pivotal for learning memory, with OLs OPCs playing a crucial role neural circuit development, synaptic modulation, myelination dynamics. Myelination not only supports axonal conduction but also undergoes adaptive modifications response to neuronal activity, which vital cognitive processing memory functions. review discusses how these cellular myelin dynamics are implicated various neurocircuit diseases disorders such as epilepsy, gliomas, psychiatric conditions, focusing on maladaptive changes contribute disease pathology influence clinical outcomes. It covers the potential new diagnostics therapeutic approaches, including pharmacological strategies emerging biomarkers functions processes. evidence fundamental plasticity functionality synchronizing activity high-level functions, offering promising avenues targeted interventions CNS disorders.

Язык: Английский

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Treatment of Pediatric Drug-Resistant Generalized Epilepsy with Responsive Neurostimulation of the Centromedian Nucleus of the Thalamus: A Case Series of Seven Patients

Epilepsy Research, Год журнала: 2025, Номер 210, С. 107516 - 107516

Опубликована: Янв. 23, 2025

Язык: Английский

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High performance photoelectric neural electrode with laser-induced ordered reconstruction and tissue-like interface for acute seizure therapy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160263 - 160263

Опубликована: Фев. 1, 2025

Язык: Английский

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Thalamic volumetric analysis in Developmental and/or Epileptic Encephalopathy with Spike Wave Activation in Sleep (D/EE-SWAS): A cross-sectional study

Seizure, Год журнала: 2025, Номер 127, С. 94 - 100

Опубликована: Март 11, 2025

Язык: Английский

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Relationships and representations of brain structures, connectivity, dynamics and functions

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111332 - 111332

Опубликована: Март 1, 2025

Язык: Английский

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Long-term seizure reduction in generalized epilepsy after anterior nucleus of the thalamus stimulation

Epilepsy & Behavior, Год журнала: 2025, Номер 167, С. 110389 - 110389

Опубликована: Апрель 7, 2025

Язык: Английский

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A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons

Brain Research, Год журнала: 2025, Номер unknown, С. 149654 - 149654

Опубликована: Апрель 1, 2025

Язык: Английский

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Ethosuximide Induced Raynaud's Phenomenon in a Child With Childhood Absence Epilepsy

Journal of Child Neurology, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Язык: Английский

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Seizure Disorders: Clinical Insights and Review of the Major Clinical Topics Impacting the Reproductive Lifespan

Neurology - the American medical journal., Год журнала: 2025, Номер unknown, С. 96 - 111

Опубликована: Май 20, 2025

The medical management of women with epilepsy is an evolving specialization within neurology and epileptology. This article highlights the major topics key challenges, providing clinical insights regarding best current practices alongside associated rationales recommendations this emerging field. Additionally, identifies opportunities for further study outlines gaps limitations in understanding.

Язык: Английский

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