Journal of Clinical Epidemiology, Год журнала: 2023, Номер 169, С. 111170 - 111170
Опубликована: Сен. 13, 2023
Язык: Английский
Brain stimulation, Год журнала: 2023, Номер 16(5), С. 1292 - 1296
Опубликована: Авг. 10, 2023
BackgroundSleep dysfunction is disabling in people with Parkinson's disease and linked to worse motor non-motor outcomes. Sleep-specific adaptive Deep Brain Stimulation has the potential target pathophysiologies of sleep.ObjectiveDevelop an algorithm that modulates stimulation parameters response intracranially classified sleep stages.MethodsWe performed at-home, multi-night intracranial electrocorticography polysomnogram recordings train personalized linear classifiers for discriminating N3 NREM stage. Classifiers were embedded into investigational Stimulators specific DBS.ResultsWe report high specificity embedded, autonomous, stage classification across two participants provide proof-of-principle successful Stimulation.ConclusionMulti-night cortico-basal experimental framework investigate pathophysiology mechanistic interactions stimulation, towards development therapeutic neurostimulation paradigms directly targeting dysfunction.
Язык: Английский
Процитировано
32
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Фев. 27, 2024
Abstract Sleep disturbance is a prevalent and disabling comorbidity in Parkinson’s disease (PD). We performed multi-night (n = 57) at-home intracranial recordings from electrocorticography subcortical electrodes using sensing-enabled Deep Brain Stimulation (DBS), paired with portable polysomnography four PD participants one cervical dystonia (clinical trial: NCT03582891). Cortico-basal activity delta increased beta decreased during NREM (N2 + N3) versus wakefulness PD. DBS caused further elevation cortical decrease alpha low-beta compared to OFF state. Our primary outcome demonstrated an inverse interaction between slow-wave NREM. secondary revealed increases prior spontaneous awakenings classified vs. high accuracy both traditional (30 s: 92.6 ± 1.7%) rapid (5 88.3 2.1%) data epochs of signals. findings elucidate sleep neurophysiology impacts on informing adaptive for dysfunction.
Язык: Английский
Процитировано
12
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Сен. 5, 2023
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance among most common non-motor symptoms PD, but its relationship unknown. To investigate clinical potential of as a sleep quality we recorded pallidal local field potentials during polysomnography PD patients off dopaminergic medication and compared results dystonia patients. exhibited sustained elevated across wakefulness, rapid eye movement (REM), non-REM sleep, which was correlated disturbance. Simulation stimulation revealed that sleep-related changes remain unaccounted by current algorithms, negative outcomes overall life
Язык: Английский
Процитировано
23
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Май 30, 2024
Abstract Circadian rhythms have been shown in the subthalamic nucleus (STN) Parkinson’s disease (PD), but only a few studies focused on globus pallidus internus (GPi). This retrospective study investigates GPi circadian large cohort of subjects with PD (130 recordings from 93 subjects) activity chronically recorded their home environment. We found significant change between daytime and nighttime most (82.4%), reduction at 56.2% an increase 26.2%. higher frequency bands ( > 20 Hz) was more likely to decrease night patients taking extended-release levodopa medication. Our results suggest that fluctuations vary across individuals increased power might be due reemergence pathological neural activity. These findings should considered ensure successful implementation adaptive neurostimulation paradigms real-world.
Язык: Английский
Процитировано
6
Journal of Neurology Neurosurgery & Psychiatry, Год журнала: 2024, Номер unknown, С. jnnp - 332014
Опубликована: Апрель 19, 2024
Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the most common problems and represents a key prodromal marker in Parkinson's disease (PD). It remains unclear whether how basal ganglia nuclei, structures that are directly involved pathology PD, implicated occurrence RBD.
Язык: Английский
Процитировано
4
Movement Disorders, Год журнала: 2024, Номер 39(11), С. 2097 - 2102
Опубликована: Авг. 23, 2024
Automated sleep detection in movement disorders may allow monitoring sleep, potentially guiding adaptive deep brain stimulation (DBS).
Язык: Английский
Процитировано
4
Accounts of Chemical Research, Год журнала: 2024, Номер 57(9), С. 1346 - 1359
Опубликована: Апрель 17, 2024
ConspectusImplantable neurotechnology enables monitoring and stimulating of the brain signals responsible for performing cognitive, motor, sensory tasks. Electrode arrays implanted in are increasingly used clinic to treat a variety sources neurological diseases injuries. However, implantation foreign body typically initiates tissue response characterized by physical disruption vasculature neuropil as well initiation inflammation induction reactive glial states. Likewise, electrical stimulation can induce damage surrounding depending on intensity waveform parameters applied stimulus. These phenomena, turn, likely influenced surface chemistry characteristics materials employed, but further information is needed effectively link biological responses observed specific aspects device design. In order inform improved design implantable neurotechnology, we investigating basic science principles governing device–tissue integration. We employing multiple techniques characterize structural, functional, genetic changes that occur cells electrodes. First, have developed new "device-in-slice" technique capture chronically electrodes within thick slices live rat interrogation with single-cell electrophysiology two-photon imaging techniques. Our data revealed several observations remodeling devices: (a) there was significant dendritic arbors neurons near implants, where losses were driven asymmetrically implant-facing side. (b) There loss spine densities shift toward more immature (nonfunctional) morphologies. (c) reduction excitatory neurotransmission evidenced frequency postsynaptic currents (EPSCs). Lastly, (d) electrophysiological underpinnings neuronal spiking regularity. parallel, initiated studies explore gene expression devices through spatial transcriptomics, which both recording arrays. found associated hundreds genes neuroinflammation, reactivity, oligodendrocyte function, cellular metabolism induces or plasticity manner dependent upon currently developing computational analysis tools distill biomarkers interactions from large transcriptomics sets. results improve current understanding while producing benchmarking effects novel electrode designs responses. As next generation developed, it will be important understand influence materials, chemistries, implant architectures performance relationship signaling pathways.
Язык: Английский
Процитировано
3
Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(23)
Опубликована: Июнь 3, 2025
The globus pallidus externa (GPe) is a heterogeneous nucleus of the basal ganglia, with intricate connections to other ganglia nuclei, as well direct cortex. anatomic, molecular, and electrophysiologic properties cortex-projecting pallidocortical neurons are not characterized. Here, we show that project diverse motor nonmotor cortical regions, organized topographically in GPe, segregate into at least two distinct electrophysiological molecular phenotypes. In addition, find GPe receives synaptic input from deep layers some which form reciprocal onto neurons. These results demonstrate existence fast, bidirectional circuit between cortex ideally positioned integrate information about behavioral goals, internal states, environmental cues rapidly modulate behavior.
Язык: Английский
Процитировано
0
European Journal of Neurology, Год журнала: 2023, Номер 31(2)
Опубликована: Ноя. 7, 2023
Abstract Background and purpose Deep brain stimulation (DBS) has emerged as a promising treatment for movement disorders. This prospective study aims to evaluate the effects of bilateral subthalamic nucleus DBS (STN‐DBS) on motor non‐motor symptoms in patients with primary Meige syndrome. Methods Thirty who underwent STN‐DBS between April 2017 June 2020 were included. Standardized validated scales utilized assess severity dystonia, health‐related quality life, sleep, cognitive function mental status at baseline 1 year 3 years after neurostimulation. Results The Burke−Fahn−Marsden Dystonia Rating Scale scores showed mean improvement 63.0% 66.8% years, respectively, Similarly, disability improved by 60.8% 63.3% same time points. Postoperative life demonstrated significant sustained throughout follow‐up period. However, function, status, sleep other neuropsychological functions did not change Eight adverse events occurred six patients, but no deaths or permanent sequelae reported. Conclusions Bilateral is safe effective alternative syndrome, leading improvements life. Nevertheless, it yield amelioration cognitive, mental,
Язык: Английский
Процитировано
5
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июнь 26, 2023
ABSTRACT Background Sleep disturbance is a prevalent and highly disabling comorbidity in individuals with Parkinson’s disease (PD) that leads to worsening of daytime symptoms, accelerated progression reduced quality life. Objectives We aimed investigate changes sleep neurophysiology PD particularly during non-rapid eye movement (NREM) sleep, both the presence absence deep brain stimulation (DBS). Methods Multi-night (n=58) intracranial recordings were performed at-home, from chronic electrocorticography subcortical electrodes, sensing-enabled DBS pulse generators, paired portable polysomnography. Four people one person cervical dystonia evaluated determine neural structures, signals connections modulated NREM prior spontaneous awakenings. Recordings ON OFF conventional dopaminergic replacement medications. Results demonstrate an increase cortico-basal slow wave activity delta (1-4 Hz) decrease beta (13-31 (N2 N3) versus wakefulness PD. Cortical-subcortical coherence was also found be higher range lower wakefulness. resulted further elevation cortical alpha (8-13 low (13-15 power compared state. During we observed strong inverse interaction between increases Conclusions Chronic, multi-night reveal opposing stage specific modulations connectivity NREM, effects are enhanced DBS. Within specifically, strongly inversely correlated predict find therapy appears improve partially through direct modulation oscillations. Our findings help elucidate contributory mechanism responsible for disturbances highlight potential biomarkers future precision neuromodulation therapies targeting
Язык: Английский
Процитировано
4