Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Язык: Английский
Update on the roles and applications of extracellular vesicles in depression
World Journal of Psychiatry,
Год журнала:
2025,
Номер
15(3)
Опубликована: Фев. 26, 2025
Depression
is
a
prevalent
mental
disorder
that
affects
numerous
individuals,
manifesting
as
persistent
anhedonia,
sadness,
and
hopelessness.
Despite
extensive
research,
the
exact
causes
optimal
treatment
approaches
for
depression
remain
unclear.
Extracellular
vesicles
(EVs),
which
carry
biological
molecules
such
proteins,
lipids,
nucleic
acids,
metabolites,
have
emerged
crucial
players
in
both
pathological
physiological
processes.
EVs
derived
from
various
sources
exert
distinct
effects
on
depression.
Specifically,
released
by
neurons,
astrocytes,
microglia,
oligodendrocytes,
immune
cells,
stem
even
bacteria
contribute
to
pathogenesis
of
Moreover,
there
growing
interest
potential
diagnostic
therapeutic
tools
This
review
provides
comprehensive
overview
recent
research
different
sources,
their
roles
depression,
clinical
applications.
Язык: Английский
The Role of Exosomes Derived from Various Sources in Facilitating the Healing of Chronic Refractory Wounds
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107753 - 107753
Опубликована: Апрель 1, 2025
Chronic
refractory
wounds
(CRWs)
represent
a
common
and
challenging
issue
in
clinical
practice,
including
diabetic
foot
ulcers,
pressure
venous
arterial
ulcers.
These
significantly
impact
patients'
quality
of
life
may
lead
to
severe
consequences
such
as
amputation.
Their
treatment
requires
comprehensive
consideration
both
the
patient's
overall
physical
condition
local
wound
situation.
The
major
challenges
include
complex
pathogenesis,
long
cycle,
high
recurrence
rate,
heavy
economic
on
patients.
Exosomes
an
emerging
therapeutic
modality
with
characteristics
low
immunogenicity,
good
biostability,
targeting
efficiency
diseases.
derived
from
different
sources
exhibit
heterogeneity,
demonstrating
their
respective
advantages
unique
properties
treatment.
This
article
delves
into
potential
applications
mechanisms
action
exosomes
various
CRWs,
aiming
provide
new
perspectives
ideas
for
management
wounds.
Язык: Английский
Extracellular Vesicles as Diagnostic Metrics for Cardiovascular Disease: Where We are and How to Achieve in Clinics
Journal of Cardiovascular Translational Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 2, 2025
As
one
of
the
leading
causes
death
globally,
early
diagnosis
and
prevention
cardiovascular
disease
have
become
focus
clinical
public
health.
Extracellular
vesicles
(EVs)
are
small,
double-layered
membrane
structures
actively
secreted
by
cells
widely
present
in
body
fluids
such
as
blood,
urine,
saliva.
They
carry
various
bioactive
molecules,
including
proteins
nucleic
acids,
known
for
their
remarkable
stability
easy
accessibility,
making
them
promising
candidates
identifying
disease.
This
review
summarizes
applications
EVs
disease,
explores
potential
biomarkers
RNAs
(such
miRNA,
lncRNA,
circRNA)
contained
within
EVs,
discusses
prospects
challenges
EV
applications.
Язык: Английский
Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”
Neurobiology of Disease,
Год журнала:
2024,
Номер
unknown, С. 106666 - 106666
Опубликована: Сен. 1, 2024
Язык: Английский
The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 2, 2024
Heart
failure
(HF)
is
a
complex
and
debilitating
condition
characterized
by
the
heart's
inability
to
pump
blood
effectively,
leading
significant
morbidity
mortality.
The
abnormality
of
immune
response
key
factor
in
progression
HF,
contributing
adverse
cardiac
remodeling
dysfunction.
Exosomal
microRNAs
(miRNAs)
play
pivotal
role
regulating
gene
expression
cellular
function,
which
are
integral
crosstalk
between
cells,
influencing
cell
functions,
such
as
macrophage
polarization,
T
activity,
cytokine
production,
thereby
modulating
various
pathological
processes
inflammation,
fibrosis,
This
review
emphasizes
immune-regulatory
exosomal
miRNAs
HF
highlights
their
clinical
potential
diagnostic
biomarkers
therapeutic
agents.
Язык: Английский