Exosomes in Regulating miRNAs for Biomarkers of Neurodegenerative Disorders
Molecular Neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 7, 2025
Language: Английский
Update on the roles and applications of extracellular vesicles in depression
Jing Wu,
No information about this author
Jian Lü,
No information about this author
Muyi Pan
No information about this author
et al.
World Journal of Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(3)
Published: Feb. 26, 2025
Depression
is
a
prevalent
mental
disorder
that
affects
numerous
individuals,
manifesting
as
persistent
anhedonia,
sadness,
and
hopelessness.
Despite
extensive
research,
the
exact
causes
optimal
treatment
approaches
for
depression
remain
unclear.
Extracellular
vesicles
(EVs),
which
carry
biological
molecules
such
proteins,
lipids,
nucleic
acids,
metabolites,
have
emerged
crucial
players
in
both
pathological
physiological
processes.
EVs
derived
from
various
sources
exert
distinct
effects
on
depression.
Specifically,
released
by
neurons,
astrocytes,
microglia,
oligodendrocytes,
immune
cells,
stem
even
bacteria
contribute
to
pathogenesis
of
Moreover,
there
growing
interest
potential
diagnostic
therapeutic
tools
This
review
provides
comprehensive
overview
recent
research
different
sources,
their
roles
depression,
clinical
applications.
Language: Английский
The Role of Exosomes Derived from Various Sources in Facilitating the Healing of Chronic Refractory Wounds
Fengdan Xu,
No information about this author
Qiling Zhang,
No information about this author
Yuling Liu
No information about this author
et al.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107753 - 107753
Published: April 1, 2025
Chronic
refractory
wounds
(CRWs)
represent
a
common
and
challenging
issue
in
clinical
practice,
including
diabetic
foot
ulcers,
pressure
venous
arterial
ulcers.
These
significantly
impact
patients'
quality
of
life
may
lead
to
severe
consequences
such
as
amputation.
Their
treatment
requires
comprehensive
consideration
both
the
patient's
overall
physical
condition
local
wound
situation.
The
major
challenges
include
complex
pathogenesis,
long
cycle,
high
recurrence
rate,
heavy
economic
on
patients.
Exosomes
an
emerging
therapeutic
modality
with
characteristics
low
immunogenicity,
good
biostability,
targeting
efficiency
diseases.
derived
from
different
sources
exhibit
heterogeneity,
demonstrating
their
respective
advantages
unique
properties
treatment.
This
article
delves
into
potential
applications
mechanisms
action
exosomes
various
CRWs,
aiming
provide
new
perspectives
ideas
for
management
wounds.
Language: Английский
Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 106666 - 106666
Published: Sept. 1, 2024
Language: Английский
The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 2, 2024
Heart
failure
(HF)
is
a
complex
and
debilitating
condition
characterized
by
the
heart's
inability
to
pump
blood
effectively,
leading
significant
morbidity
mortality.
The
abnormality
of
immune
response
key
factor
in
progression
HF,
contributing
adverse
cardiac
remodeling
dysfunction.
Exosomal
microRNAs
(miRNAs)
play
pivotal
role
regulating
gene
expression
cellular
function,
which
are
integral
crosstalk
between
cells,
influencing
cell
functions,
such
as
macrophage
polarization,
T
activity,
cytokine
production,
thereby
modulating
various
pathological
processes
inflammation,
fibrosis,
This
review
emphasizes
immune-regulatory
exosomal
miRNAs
HF
highlights
their
clinical
potential
diagnostic
biomarkers
therapeutic
agents.
Language: Английский