bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Many pregnant women use cannabidiol (CBD) as a natural remedy to alleviate symptoms such nausea, insomnia, anxiety, and chronic pain. As much 20% of pregnancies in the USA Canada may involve CBD-only products. CBD crosses placenta affect fetal development, potentially leading neuropsychiatric conditions later life. Given limited understanding effects during pregnancy, we adopted longitudinal approach investigate neurodevelopmental trajectory associated with prenatal exposure. Pregnant mice were administered 3 mg/kg from gestational days 5 18. At early adolescence, offspring displayed sex-specific behavioral changes. Females, but not males, exhibited complex anxiety-like phenotype elevated plus maze task. This persisted into adulthood open field test was accompanied by altered reward responsiveness. Throughout post-natal life, female demonstrated heightened stretch-attend postures, risk-assessment behavior reflecting approach-avoidance tendencies anxiety. Finally, exposure increased repetitive behaviors adult animals both sexes, evidenced marble burying These results provide strong evidence disruptions developmental trajectories anxiety They challenge perception that is universally safe highlight vulnerabilities linked
Language: Английский
