Biological Research For Nursing,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 5, 2024
Objectives:
Inflammation
contributes
to
disparate
neurodevelopmental
outcomes
between
preterm
and
term-born
infants.
In
this
context,
DNA
methylation
may
contribute
inflammation
by
affecting
gene
expression.
Brain-derived
neurotrophic
factor
(
BDNF)
nuclear
factor-kappa-B-inhibitor
alpha
NFKBIA)
are
important
genes
for
targeted
analysis.
The
aims
of
study
were
(1)
identify
associations
inflammatory
factors
BDNF
NFKBIA
,
(2)
early
neurobehavior
in
Methods:
a
longitudinal
cohort
infants
born
28–31
weeks
gestational
age,
blood
samples
collected
weekly
the
quantification
factors.
We
extracted
from
saliva
quantified
six
cytosine-phosphate-guanine
(CpG)
sites
five
CpG
sites.
Neurobehavior
was
assessed
using
Neurobehavioral
Assessment
Preterm
Infant.
Results:
Sixty-five
included
females,
positively
associated
with
most
Interleukin-1
receptor
antagonist
negatively
at
two
males,
interleukin-6
inversely
motor
performance.
one
site
Conclusion:
This
provides
evidence
relationship
infants,
working
mechanistically
through
methylation.
finding
difference
males
females
suggests
that
female
potentially
more
vulnerable
warrants
future
study.
Biomolecules,
Год журнала:
2024,
Номер
14(2), С. 191 - 191
Опубликована: Фев. 4, 2024
We
review
emerging
preclinical
and
clinical
evidence
regarding
brain-derived
neurotrophic
factor
(BDNF)
protein,
genotype,
DNA
methylation
(DNAm)
as
biomarkers
of
outcomes
in
three
important
etiologies
pediatric
acquired
brain
injury
(ABI),
traumatic
injury,
global
cerebral
ischemia,
stroke.
also
summarize
suggesting
that
BDNF
is
(1)
involved
the
biological
embedding
psychosocial
environment,
(2)
responsive
to
rehabilitative
therapies,
(3)
potentially
modifiable.
BDNF’s
unique
potential
a
biomarker
neuroplasticity
neural
repair
reflective
both
pre-
post-injury
environmental
influences
separates
it
from
traditional
protein
structural
with
exciting
advance
ABI
management
by
increasing
accuracy
prognostic
tools
informing
decision
making
through
monitoring
therapeutic
effects.
Neuroprotection/Neuroprotection (Chichester, England. Print),
Год журнала:
2024,
Номер
2(2), С. 67 - 78
Опубликована: Май 2, 2024
Abstract
Neurodegenerative
diseases,
marked
by
the
gradual
death
of
neurons,
present
a
significant
and
growing
public
health
challenge.
Brain‐derived
neurotrophic
factor
(BDNF)
is
crucial
for
survival,
development,
synaptic
plasticity
neurons.
Studies
have
consistently
demonstrated
that
perturbed
BDNF
communication
pathways
are
associated
with
development
progression
neurodegenerative
conditions,
underscoring
their
potential
as
therapeutic
targets.
This
review
aimed
to
summarize
existing
findings
regarding
expression,
metabolism,
signaling
transduction.
Furthermore,
we
reviewed
intricate
roles
in
elucidating
contributions
disease
onset
progression.
The
latest
advancements
targeting
treatment
including
small
molecules,
nucleic
acid‐based
therapeutics,
antibody‐based
approaches,
were
also
summarized.
Despite
recent
strides,
challenges
persist,
lack
comprehensive
understanding
modulation
across
diverse
contexts
absence
clinically
approved
BDNF‐targeted
drugs.
Biomedicines,
Год журнала:
2023,
Номер
11(8), С. 2275 - 2275
Опубликована: Авг. 16, 2023
Brain-derived
neurotrophic
factor
(BDNF)
is
a
major
neurotrophin
whose
loss
or
interruption
well
established
to
have
numerous
intersections
with
the
pathogenesis
of
progressive
neurological
disorders.
There
perhaps
no
greater
example
disease
resulting
from
dysregulation
BDNF
signaling
than
Huntington’s
(HD)—an
inherited
neurodegenerative
disorder
characterized
by
motor,
psychiatric,
and
cognitive
impairments
associated
basal
ganglia
dysfunction
ultimate
death
striatal
projection
neurons.
Investigation
collection
mechanisms
leading
in
HD
highlights
this
neurotrophin’s
importance
neuronal
viability
calls
attention
opportunities
for
therapeutic
interventions.
Using
electronic
database
searches
existing
forthcoming
research,
we
constructed
literature
review
overarching
goal
exploring
diverse
set
molecular
events
that
trigger
within
HD.
We
highlighted
research
investigated
these
preclinical
models
connected
studies
those
evaluating
similar
endpoints
human
subjects.
also
included
special
focus
on
growing
body
detailing
key
transcriptomic
epigenetic
alterations
affect
abundance
Finally,
offer
critical
evaluation
proposed
neurotrophin-directed
therapies
assessed
clinical
trials
seeking
correct
expression
individuals.
Frontiers in Public Health,
Год журнала:
2023,
Номер
11
Опубликована: Авг. 30, 2023
Fluoride
is
considered
an
environmental
pollutant
that
seriously
affects
organisms
and
ecosystems,
its
harmfulness
a
perpetual
public
health
concern.
The
toxic
effects
of
fluoride
include
organelle
damage,
oxidative
stress,
cell
cycle
destruction,
inflammatory
factor
secretion,
apoptosis
induction,
synaptic
nerve
transmission
destruction.
To
reveal
the
mechanism
fluorosis-induced
brain
we
analyzed
molecular
learning
memory
function
SIRT1-mediated
BDNF-TrkB
signaling
pathway
cascade
reaction
in
damage
through
vivo
experiments.This
study
constructed
rat
models
drinking
water
fluorosis
using
50
mg/L,
100
150
mg/L
fluoride,
observed
occurrence
dental
rats.
Subsequently,
measured
content
blood,
urine,
bones,
abilities.
Furthermore,
stress
products,
levels,
acetylcholinesterase
(AchE)
choline
acetyltransferase
(ChAT)
activity
were
detected.
pathological
structural
changes
to
bones
tissue
observed.
SIRT1,
BDNF,
TrkB,
apoptotic
protein
levels
determined
western
blotting.All
rats
exposure
groups
exhibited
fluorosis;
decreased
abilities;
higher
urinary
bone
blood
product,
compared
control
group.
fluoride-exposed
had
abnormal
AchE
ChAT
activity,
sparsely
arranged
hippocampal
neurons,
blurred
boundaries,
significantly
fewer
astrocytes,
swollen
cells.
nucleoli
absent
from
tissue,
which
also
contained
folded
neuron
membranes,
deformed
mitochondria,
cristae,
vacuole
formation,
pyknotic
hyperchromatic
chromatin.
lower
TrkB
than
group,
closely
related
dose.
findings
demonstrated
excessive
caused
affected
abilities.Currently,
there
no
effective
treatment
method
for
by
fluorosis.
Therefore,
preventing
treating
intake.
Annals of General Psychiatry,
Год журнала:
2025,
Номер
24(1)
Опубликована: Апрель 4, 2025
Schizophrenia
is
a
complex,
heterogeneous,
and
highly
disabling
severe
mental
disorder
whose
pathogenesis
has
not
yet
been
fully
elucidated.
Epigenetics,
as
bridge
between
genetic
environmental
factors,
plays
an
important
role
in
the
pathophysiology
of
schizophrenia.
Over
past
decade,
epigenetic-wide
association
studies
have
rapidly
become
branch
psychiatric
research,
especially
deciphering
molecular
mechanisms
This
review
systematically
analyzes
recent
advances
epigenome-wide
(EWAS)
schizophrenia,
focusing
on
technological
developments.
We
synthesize
findings
from
large-scale
EWAS
alongside
emerging
evidence
DNA
methylation
patterns,
histone
modifications,
regulatory
networks,
emphasizing
their
roles
disease
treatment
responses.
In
addition,
this
provides
prospective
outlook,
evaluating
impact
that
developments
may
future
With
continuous
advancement
high-throughput
sequencing
technology
increasing
maturity
big
data
analysis
methods,
epigenetics
expected
to
significant
early
diagnosis,
prognosis
assessment
even
personalized
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(12), С. 6250 - 6264
Опубликована: Март 16, 2024
Hydroxytyrosol
(HT;
3,4-dihydroxyphenyl
ethanol)
is
an
important
functional
polyphenol
in
olive
oil.
Our
study
sought
to
evaluate
the
protective
effects
and
underlying
mechanisms
of
HT
on
obesity-induced
cognitive
impairment.
A
high-fat
high-fructose-diet-induced
obese
mice
model
was
treated
with
for
14
weeks.
The
results
show
that
improved
learning
memory
abilities
enhanced
expressions
brain-derived
neurotrophic
factors
(BDNFs)
postsynaptic
density
proteins,
protecting
neuronal
synaptic
functions
mice.
Transcriptomic
further
confirmed
impairment
by
regulating
gene
expression
neural
system
development
function-related
pathways.
Moreover,
treatment
alleviated
neuroinflammation
brain
To
sum
up,
our
indicated
can
alleviate
dysfunction
enhancing
BDNF
alleviating
brain,
which
also
means
may
become
a
potentially
useful
nutritional
supplement
decline.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Год журнала:
2024,
Номер
20(2), С. 126 - 132
Опубликована: Апрель 19, 2024
Neurological
disorders
affect
a
large
population,
often
leading
to
different
levels
of
disability
and
resulting
in
decreased
quality
life.
Neurorehabilitation
is
the
process
restoring
functions
nervous
system
after
injuries,
diseases,
or
other
impairments.
The
molecular
basis
neurorehabilitation
includes
various
aspects
such
as
changes
gene
expression,
regulation
synaptic
connections,
nerve
cell
growth,
repair,
among
others.
Typical
objectives
rehabilitating
patient
with
neurologic
disease
are
minimize
pain,
reestablish
normal
neural
pathways,
prevent
secondary
complications,
ultimately
improve
It
also
essential
not
worsen
function
pain
patients
spinal
instability.
A
free
triiodothyronine
thyroid
stimulating
hormone
upon
admission
may
predict
an
unfavorable
outcome
at
end
early
rehabilitative
treatment.
Thus,
only
important
during
acute
treatment
but
prolonged
critical
illness.
Thyroid
hormones,
specifically
thyroxine
triiodothyronine,
can
influence
these
processes
through
their
receptors
tissue.
hormones
for
functioning
system,
including
neurogenesis
(the
formation
new
neurons)
plasticity
(changes
strength
structure
connections
between
neurons).
Research
has
shown
that
expression
genes
related
growth
survival
neurons,
well
processes,
which
be
relevant
rehabilitation
injuries.
deficiency
hypothyroidism
lead
disturbances
development
which,
turn,
complicate
process.
understanding
help
approaches
