Epigenetic Alterations in Post-Traumatic Stress Disorder: Comprehensive Review of Molecular Markers DOI
Elizaveta Golubeva, Angelina Zeltser, Yana Zorkina

et al.

Complex Psychiatry, Journal Year: 2024, Volume and Issue: 10(1-4), P. 71 - 107

Published: Nov. 18, 2024

Background: Post-traumatic stress disorder (PTSD) can occur after a traumatic event. PTSD is characterized by nightmares, flashbacks and avoidance of stressors. It currently affects 2–8% the population, with military personnel particularly susceptible. Studies show that environmental stressors induce various epigenetic changes shape phenotype. Despite significant impact factors on symptoms susceptibility, they have not been widely discussed in literature. This review focuses describing mechanisms PTSD, especially DNA methylation, chromatin regulation, noncoding RNA. Summary: The article includes relevant studies published from 2013 to 2023, excluding non-English-language or insufficient data. investigated gene methylation association including those related hypothalamic-pituitary-adrenal axis, brain-derived neurotrophic factor, neurotransmitters, immune system functioning, as well role histones regulatory RNAs. Key Messages: Epigenetic alterations play crucial shaping symptomatology, long-term outcomes, highlighting their potential important markers therapeutic targets. Understanding these aid developing clinical strategies better predict, prevent, treat PTSD. However, further large-scale longitudinal are needed establish temporal relationship between onset classify other mechanisms.

Language: Английский

Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery DOI Creative Commons
Amery Treble‐Barna, Bailey A. Petersen,

Zachary Stec

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 191 - 191

Published: Feb. 4, 2024

We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies pediatric acquired brain injury (ABI), traumatic injury, global cerebral ischemia, stroke. also summarize suggesting that BDNF is (1) involved the biological embedding psychosocial environment, (2) responsive to rehabilitative therapies, (3) potentially modifiable. BDNF’s unique potential a biomarker neuroplasticity neural repair reflective both pre- post-injury environmental influences separates it from traditional protein structural with exciting advance ABI management by increasing accuracy prognostic tools informing decision making through monitoring therapeutic effects.

Language: Английский

Citations

6
Targeting brain‐derived neurotrophic factor in the treatment of neurodegenerative diseases: A review DOI Creative Commons
Dong Wang,

Zhi‐Chen Lang,

Shi‐Nan Wei

et al.

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2024, Volume and Issue: 2(2), P. 67 - 78

Published: May 2, 2024

Abstract Neurodegenerative diseases, marked by the gradual death of neurons, present a significant and growing public health challenge. Brain‐derived neurotrophic factor (BDNF) is crucial for survival, development, synaptic plasticity neurons. Studies have consistently demonstrated that perturbed BDNF communication pathways are associated with development progression neurodegenerative conditions, underscoring their potential as therapeutic targets. This review aimed to summarize existing findings regarding expression, metabolism, signaling transduction. Furthermore, we reviewed intricate roles in elucidating contributions disease onset progression. The latest advancements targeting treatment including small molecules, nucleic acid‐based therapeutics, antibody‐based approaches, were also summarized. Despite recent strides, challenges persist, lack comprehensive understanding modulation across diverse contexts absence clinically approved BDNF‐targeted drugs.

Language: Английский

Citations

6
Brain-Derived Neurotrophic Factor Dysregulation as an Essential Pathological Feature in Huntington’s Disease: Mechanisms and Potential Therapeutics DOI Creative Commons

Andrew Speidell,

Noman Bin Abid,

Hiroko Yano

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2275 - 2275

Published: Aug. 16, 2023

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption well established to have numerous intersections with the pathogenesis of progressive neurological disorders. There perhaps no greater example disease resulting from dysregulation BDNF signaling than Huntington’s (HD)—an inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive impairments associated basal ganglia dysfunction ultimate death striatal projection neurons. Investigation collection mechanisms leading in HD highlights this neurotrophin’s importance neuronal viability calls attention opportunities for therapeutic interventions. Using electronic database searches existing forthcoming research, we constructed literature review overarching goal exploring diverse set molecular events that trigger within HD. We highlighted research investigated these preclinical models connected studies those evaluating similar endpoints human subjects. also included special focus on growing body detailing key transcriptomic epigenetic alterations affect abundance Finally, offer critical evaluation proposed neurotrophin-directed therapies assessed clinical trials seeking correct expression individuals.

Language: Английский

Citations

13
Exploration of the SIRT1-mediated BDNF–TrkB signaling pathway in the mechanism of brain damage and learning and memory effects of fluorosis DOI Creative Commons

Feiqing Wang,

Yanju Li,

Dongxin Tang

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 30, 2023

Fluoride is considered an environmental pollutant that seriously affects organisms and ecosystems, its harmfulness a perpetual public health concern. The toxic effects of fluoride include organelle damage, oxidative stress, cell cycle destruction, inflammatory factor secretion, apoptosis induction, synaptic nerve transmission destruction. To reveal the mechanism fluorosis-induced brain we analyzed molecular learning memory function SIRT1-mediated BDNF-TrkB signaling pathway cascade reaction in damage through vivo experiments.This study constructed rat models drinking water fluorosis using 50 mg/L, 100 150 mg/L fluoride, observed occurrence dental rats. Subsequently, measured content blood, urine, bones, abilities. Furthermore, stress products, levels, acetylcholinesterase (AchE) choline acetyltransferase (ChAT) activity were detected. pathological structural changes to bones tissue observed. SIRT1, BDNF, TrkB, apoptotic protein levels determined western blotting.All rats exposure groups exhibited fluorosis; decreased abilities; higher urinary bone blood product, compared control group. fluoride-exposed had abnormal AchE ChAT activity, sparsely arranged hippocampal neurons, blurred boundaries, significantly fewer astrocytes, swollen cells. nucleoli absent from tissue, which also contained folded neuron membranes, deformed mitochondria, cristae, vacuole formation, pyknotic hyperchromatic chromatin. lower TrkB than group, closely related dose. findings demonstrated excessive caused affected abilities.Currently, there no effective treatment method for by fluorosis. Therefore, preventing treating intake.

Language: Английский

Citations

12
Epigenetic regulation of stress DOI
Mariam K. Alamoudi,

Noura N. Alibrahim,

Abdulmonem A. Alsaleh

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Epigenetics factors in schizophrenia: future directions for etiologic and therapeutic study approaches DOI Creative Commons
Haidong Yang, Wenxi Sun, Jin Li

et al.

Annals of General Psychiatry, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 4, 2025

Schizophrenia is a complex, heterogeneous, and highly disabling severe mental disorder whose pathogenesis has not yet been fully elucidated. Epigenetics, as bridge between genetic environmental factors, plays an important role in the pathophysiology of schizophrenia. Over past decade, epigenetic-wide association studies have rapidly become branch psychiatric research, especially deciphering molecular mechanisms This review systematically analyzes recent advances epigenome-wide (EWAS) schizophrenia, focusing on technological developments. We synthesize findings from large-scale EWAS alongside emerging evidence DNA methylation patterns, histone modifications, regulatory networks, emphasizing their roles disease treatment responses. In addition, this provides prospective outlook, evaluating impact that developments may future With continuous advancement high-throughput sequencing technology increasing maturity big data analysis methods, epigenetics expected to significant early diagnosis, prognosis assessment even personalized

Language: Английский

Citations

0
Prenatal Sleep Restriction Altered Learning Ability and Memory Behaviour by Decreasing Hippocampal Synaptic Plasticity in Offspring Mice DOI
Natasha Chitakwa,

Na Chen,

Chuan‐Mu Chen

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106500 - 106500

Published: April 1, 2025

Language: Английский

Citations

0
Hydroxytyrosol Alleviates Obesity-Induced Cognitive Decline by Modulating the Expression Levels of Brain-Derived Neurotrophic Factors and Inflammatory Factors in Mice DOI
Shenlin Liu, Yalong Lu,

Dan Tian

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(12), P. 6250 - 6264

Published: March 16, 2024

Hydroxytyrosol (HT; 3,4-dihydroxyphenyl ethanol) is an important functional polyphenol in olive oil. Our study sought to evaluate the protective effects and underlying mechanisms of HT on obesity-induced cognitive impairment. A high-fat high-fructose-diet-induced obese mice model was treated with for 14 weeks. The results show that improved learning memory abilities enhanced expressions brain-derived neurotrophic factors (BDNFs) postsynaptic density proteins, protecting neuronal synaptic functions mice. Transcriptomic further confirmed impairment by regulating gene expression neural system development function-related pathways. Moreover, treatment alleviated neuroinflammation brain To sum up, our indicated can alleviate dysfunction enhancing BDNF alleviating brain, which also means may become a potentially useful nutritional supplement decline.

Language: Английский

Citations

3
Changes in BDNF methylation patterns after cognitive remediation therapy in schizophrenia: A randomized and controlled trial DOI
Rafael Penadés, Carmen Almodóvar-Payá, Clemente García‐Rizo

et al.

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 173, P. 166 - 174

Published: March 23, 2024

Language: Английский

Citations

3
Epigenetic and Mental Diseases: The Role of Psychotherapy DOI Creative Commons
Leonardo Massoni

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(3), P. 450 - 462

Published: July 11, 2024

It is well known that mental illness often the result of genetic susceptibility combined with environmental factors. In this context, it useful to consider role changes in DNA expression, as epigenetic, can play development and progression psychiatric disorders. Accordingly, psychotherapy, a form pharmacological strategy targets dysfunctional emotions behaviors, may also improve symptoms via epigenetic changes. This article reviews current literature on induced by psychotherapy disorders, pointing out encouraging findings for borderline personality disorder (BPD), post-traumatic stress (PTSD), anxiety disorders obsessive–compulsive (OCD). focuses genes are more commonly associated paves way further research.

Language: Английский

Citations

2