Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome

Neurobiology of Stress, Год журнала: 2024, Номер 31, С. 100652 - 100652

Опубликована: Май 31, 2024

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas enduring impact ELA on cognitive and emotional health is established, there are no tools to predict vulnerability consequences in an individual child. Epigenetic markers including peripheral-cell DNA-methylation profiles may encode provide predictive outcome markers, yet interindividual variance human genome rapid changes DNA methylation childhood pose significant challenges. Hoping mitigate these challenges we examined relation several dimensions using within-subject longitudinal design high methylation-change threshold. was analyzed buccal swab / saliva samples collected twice (neonatally at 12 months) 110 infants. We identified CpGs differentially methylated across time for each child determined whether they associated with indicators executive function age 5. assessed sex differences derived sex-dependent 'impact score' based sites that most contributed changes. Changes between two reflected age-related trends correlated years later. Among tested life factors income needs ratios, maternal sensitivity, body mass index infant sex, unpredictability parental household signals strongest predictor function. In girls, interacted presage Thus, longitudinal, signature potential marker outcome.

Язык: Английский

---

Childhood Maltreatment and Longitudinal Epigenetic Aging

JAMA Network Open, Год журнала: 2024, Номер 7(7), С. e2421877 - e2421877

Опубликована: Июль 29, 2024

Importance Child physical and emotional abuse neglect may affect epigenetic signatures of accelerated aging several years after the exposure. Objective To examine longitudinal outcomes early-childhood midchildhood exposures to maltreatment on later childhood adolescent profiles aging. Design, Setting, Participants This cohort study used data from Future Families Wellbeing Study (enrolled 1998-2000), a US birth with available DNA methylation (DNAm) at ages 9 15 (assayed between 2017 2020) phenotypic (wave 1), 3 3), 5 4), 5), 6) years. Data were analyzed June 18 December 10, 2023. Exposures Emotional aggression, assault, neglect, via Parent-Child Conflict Tactics Scale Main Outcomes Measures Epigenetic (DNAmAA) was measured using machine learning–derived surrogates (GrimAge, PhenoAge, DunedinPACE) 2 age (Horvath PedBE), residualized for in months. Results A total 1971 children (992 [50.3%] male) representative births large cities 1998 2000 included. Physical assault positively associated DNAmAA PhenoAge (β = 0.073; 95% CI, 0.019-0.127), aggression negatively −0.107; −0.162 −0.052). 0.051; 0.006-0.097). Cumulative exposure 0.063; 0.003-0.123); −0.104; −0.165 −0.043). The association these measures almost fully mediated by DNAm acceleration. Similar patterns found GrimAge, DunedinPACE, but only those remained adjustments multiple comparisons. Conclusions Relevance In this study, altered sensitive type timing child appeared be more proximate biological embedding stress.

Язык: Английский

---

Epigenetics of childhood obesity

Hormone Research in Paediatrics, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Янв. 14, 2025

Background: Childhood obesity has become a global pandemic and is one of the strongest risk factors for cardiovascular disease later in life. The correlation epigenetic marks with related traits being elucidated. This review summarizes latest research its challenges study epigenetics (childhood) obesity. Summary: Epigenome-wide association studies helped to identify novel targets methylation sites that are important pathophysiology In future, such will essential developing scores (MRS) metabolic diseases. Although MRS very promising predicting individual obesity, implementation challenging not been introduced into clinical practice so far. Key Messages: Future undoubtedly discover numerous may be involved development comorbidities, especially at young age. contribute better understanding complex etiology human From perspective, overarching aim generate robust reliable accurate prediction comorbidities.

Язык: Английский

---

Intergenerational transmission of complex traits and the offspring methylome

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Abstract The genetic makeup of parents can directly or indirectly affect their offspring phenome through transmission via the environment that is influenced by parental heritable traits. Our understanding mechanisms which indirect effects operate limited. Here, we hypothesize one mechanism methylome. To test this hypothesis, polygenic scores (PGSs) for schizophrenia, smoking initiation, educational attainment (EA), social deprivation, body mass index (BMI), and height were analyzed in a cohort 1528 (51.5% boys, mean [ SD ] age = 10 [2.8] years). We modelled parent PGSs on buccal-DNA methylation, accounting own PGS offspring, found significant associations between EA, BMI, height, buccal methylation sites, comprising 16, 2, 1, 6 respectively (alpha 2.7 × −5 ). More DNA sites associated with maternal than paternal PGSs, possibly reflecting pre- periconceptional stronger involvement shaping offspring’s during early childhood.

Язык: Английский

---

Childhood Experiences of Corporal Punishment and Associated Intimate Partner Violence Perpetration and Victimization in Adulthood: Results from a Longitudinal Twin Study

Journal of Family Violence, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Abstract Purpose Corporal punishment has been widely accepted to have adverse effects on children in childhood, however, less is known about its distal effects. The current study uses data from a longitudinal Australian twin estimate the association between experiencing corporal childhood and involvement adult physical intimate partner violence (PIPV) as victim or perpetrator. Methods sample (N = 1532) consisted of 644 pairs 244 singletons. experiences were categorised two ways: no any punishment; categorized being by hand, with an object, both hand neither. We used mixed-effect Poisson regression robust standard errors relative risk ratios quantify punishment, PIPV victimisation perpetration, while controlling for sexual abuse, witnessing domestic violence. Results Respondents who experienced their father 38 40% more likely become PIPV; 37 41% perpetrator PIPV. There was evidence mothers perpetration. An analysis perpetration among monozygotic twins different inconclusive. Conclusion Experiencing particularly father, factor adulthood, Understanding this link may help inform primary prevention strategies.

Язык: Английский

---

The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment

Journal of Psychiatric Research, Год журнала: 2023, Номер 165, С. 7 - 13

Опубликована: Июль 8, 2023

Язык: Английский

---

Mother adversity and co-residence time impact mother-child similarity in genome-wide and gene-specific methylation profiles

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 2, 2024

Background. The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underlying mechanism, have been extensively studied. However, the epigenetic resemblance between mother child in context neglectful caregiving, whether it may be shaped by emotional impact maternal stressful duration co-residence (indexed age), remains unknown. present study examined mother-child similarity profiles, considering potential effect adversity, empathy, neglect-control group, age (an index years co-residence), age. We quantified DNAm 115 saliva samples obtained computing correlation coefficients profiles within dyads, for entire epigenome, five specific genes related to stress empathy: NR3C1, FKPB5, OXTR, SCL6A4, BDNF. Results. familial pairs significantly correlated compared random epigenome FKBP5, OXTR BDNF genes. Next, multiple linear regression models observed associations age, group similarity, only significant pairs, after correcting comparisons. Higher adversity was associated lower epigenome-wide analysis, gene, gene. In turn, being an older (longer co-residence) higher similarity. Conclusions. Mother time are modulating factors intergenerational process that offer window into development-dependent adaptations can affected both hereditary environmental factors, biological dyads. A twofold implication well-being emerges, one is positive children mothers exposed or neglect did not necessarily inherit their patterns. other worrisome, since living together crucial factor high transmission children, reinforcing need “the earlier, better” recommendation Child Protection System, which always followed.

Язык: Английский

---

Mediation of DNA methylation (cg04622888 and cg05037505) in the association between childhood maltreatment and non-suicidal self-injury in early adolescents

European Child & Adolescent Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Язык: Английский

---

Validity and use of the Neonatal Infant Stressor Scale: An integrative review

Early Human Development, Год журнала: 2024, Номер 199, С. 106146 - 106146

Опубликована: Ноя. 4, 2024

Язык: Английский

---

Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles

Clinical Epigenetics, Год журнала: 2024, Номер 16(1)

Опубликована: Март 20, 2024

Abstract Background The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underlying mechanism, have been extensively studied. However, the epigenetic resemblance between mother child in context neglectful caregiving, whether it may be shaped by emotional impact maternal stressful duration co-residence (indexed age), remains unknown. present study examined mother–child similarity profiles, considering potential effect adversity, empathy, neglect-control group, age (an index years co-residence), age. Using Illumina Epic arrays, we quantified DNAm 115 saliva samples. We obtained computing correlation coefficients profiles within dyads, for entire epigenome, five specific genes related to stress empathy: NR3C1, FKPB5, OXTR, SCL6A4, BDNF. Results familial pairs significantly correlated compared random epigenome FKBP5, OXTR BDNF genes. Next, multiple linear regression models observed associations age, group similarity, only significant pairs, after correcting comparisons. Higher adversity was associated lower epigenome-wide analysis, gene, gene. In turn, being an older (longer co-residence) higher similarity. Conclusions Mother time are modulating factors intergenerational process that offer window into development-dependent adaptations can affected both hereditary environmental factors, biological dyads. A twofold implication well-being emerges, one is positive children mothers exposed or neglect did not necessarily inherit their patterns. other concerning due influence spent living together, which affects potentially increases risk inheriting profile future dysfunctional parenting This underscores importance 'the earlier, better' recommendation Child Protection System, always followed.

Язык: Английский

---