Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Сен. 5, 2024
The role of the gut microbiota in gut-brain axis has attracted attention recent years. Some produces γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter mammals,
Язык: Английский
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102689 - 102689
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Nutrients, Год журнала: 2024, Номер 16(14), С. 2244 - 2244
Опубликована: Июль 12, 2024
Aging is the most prominent risk factor for neurodegeneration occurrence. The common neurodegenerative diseases (NDs), Alzheimer’s (AD) and Parkinson’s (PD) diseases, are characterized by incidence of proteinopathy, abnormal activation glial cells, oxidative stress, neuroinflammation, impaired autophagy cellular senescence excessive patient’s age. Moreover, mitochondrial disfunction, epigenetic alterations neurogenesis inhibition, together with increased blood–brain barrier permeability gut dysbiosis, have been linked to ND pathogenesis. Since NDs still lack curative treatment, recent research has sought therapeutic options in restoring microbiota supplementing probiotic bacteria-derived metabolites beneficial action host—so called postbiotics. current review focuses on literature explaining mechanisms involved pathogenesis addressing impact that postbiotics as a whole mixture particular metabolites, such short-chain fatty acids (SCFAs), lactate, polyamines, polyphenols, tryptophan exopolysaccharides bacterial extracellular vesicles, ageing-associated processes underlying also discusses issue implementing into prophylaxis therapy, depicting them compounds senescence-triggered dysfunctions worth translating from bench pharmaceutical market response “silver consumers” demands.
Язык: Английский
Процитировано
6
The Journal of Nutritional Biochemistry, Год журнала: 2025, Номер unknown, С. 109847 - 109847
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Neurochemistry International, Год журнала: 2025, Номер unknown, С. 105948 - 105948
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(5), С. 772 - 772
Опубликована: Фев. 22, 2025
The gut microbiota influences and contributes to kidney health disease. Butyrate, a short-chain fatty acid molecule generated via the fermentation of bacterial catabolism nondigestible dietary fiber, has been shown exert numerous beneficial effects on disorders. objective this review was discuss latest findings protective butyrate variety animal models injury. We conducted PubMed search using title word "butyrate" keyword "kidney" generate our literature sources. covered in include ischemia-reperfusion renal injury, cisplatin- folic acid-induced septic diabetic disease (DKD), high-fat diet (HFD)-induced glomerulopathy, adenine-induced chronic (CKD), high-salt-induced T-2 toxin-induced injury birds. mechanisms that are most shared among these model studies antioxidative stress, anti-fibrosis, anti-inflammation, anti-cell death. This ends with suggestions for future potential approaches may modulate production well-being kidneys disorders review.
Язык: Английский
Процитировано
0
International review of neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Сен. 5, 2024
The role of the gut microbiota in gut-brain axis has attracted attention recent years. Some produces γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter mammals,
Язык: Английский
Процитировано
1