Intervention in gut microbiota increases intestinal γ-aminobutyric acid and alleviates anxiety behavior: a possible mechanism via the action on intestinal epithelial cells DOI Creative Commons

Mion Ikegami,

Hikari Narabayashi,

Kazuaki Nakata

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 5, 2024

The role of the gut microbiota in gut-brain axis has attracted attention recent years. Some produces γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter mammals,

Language: Английский

Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects DOI
Bushra Bashir, Monica Gulati, Sukriti Vishwas

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102689 - 102689

Published: Feb. 1, 2025

Language: Английский

Citations

2
Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases DOI Open Access

Pola Głowacka,

Katarzyna Oszajca, Agnieszka Pudlarz

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2244 - 2244

Published: July 12, 2024

Aging is the most prominent risk factor for neurodegeneration occurrence. The common neurodegenerative diseases (NDs), Alzheimer’s (AD) and Parkinson’s (PD) diseases, are characterized by incidence of proteinopathy, abnormal activation glial cells, oxidative stress, neuroinflammation, impaired autophagy cellular senescence excessive patient’s age. Moreover, mitochondrial disfunction, epigenetic alterations neurogenesis inhibition, together with increased blood–brain barrier permeability gut dysbiosis, have been linked to ND pathogenesis. Since NDs still lack curative treatment, recent research has sought therapeutic options in restoring microbiota supplementing probiotic bacteria-derived metabolites beneficial action host—so called postbiotics. current review focuses on literature explaining mechanisms involved pathogenesis addressing impact that postbiotics as a whole mixture particular metabolites, such short-chain fatty acids (SCFAs), lactate, polyamines, polyphenols, tryptophan exopolysaccharides bacterial extracellular vesicles, ageing-associated processes underlying also discusses issue implementing into prophylaxis therapy, depicting them compounds senescence-triggered dysfunctions worth translating from bench pharmaceutical market response “silver consumers” demands.

Language: Английский

Citations

6
Oral Tributyrin Treatment affects Short-Chain Fatty Acid Transport, Mucosal Health, and Microbiome in a Mouse Model of Inflammatory Diarrhea DOI
Zhenghao Ye, Archana Kini,

Qinghai Tan

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109847 - 109847

Published: Jan. 1, 2025

Language: Английский

Citations

0
Neuro-nutraceuticals: Emerging molecular and functional insights into how natural products improve brain health DOI
Kochupurackal P. Mohanakumar, Catarina Rendeiro, Philip M. Beart

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105948 - 105948

Published: Feb. 1, 2025

Language: Английский

Citations

0
Beneficial Effects of Butyrate on Kidney Disease DOI Open Access

Tram N. Diep,

Haoxin Liu,

Liang‐Jun Yan

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 772 - 772

Published: Feb. 22, 2025

The gut microbiota influences and contributes to kidney health disease. Butyrate, a short-chain fatty acid molecule generated via the fermentation of bacterial catabolism nondigestible dietary fiber, has been shown exert numerous beneficial effects on disorders. objective this review was discuss latest findings protective butyrate variety animal models injury. We conducted PubMed search using title word "butyrate" keyword "kidney" generate our literature sources. covered in include ischemia-reperfusion renal injury, cisplatin- folic acid-induced septic diabetic disease (DKD), high-fat diet (HFD)-induced glomerulopathy, adenine-induced chronic (CKD), high-salt-induced T-2 toxin-induced injury birds. mechanisms that are most shared among these model studies antioxidative stress, anti-fibrosis, anti-inflammation, anti-cell death. This ends with suggestions for future potential approaches may modulate production well-being kidneys disorders review.

Language: Английский

Citations

0
Disruption in the human microbiome causing behavioural changes in bipolar disorder DOI
Sandhya Srinivasan

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Intervention in gut microbiota increases intestinal γ-aminobutyric acid and alleviates anxiety behavior: a possible mechanism via the action on intestinal epithelial cells DOI Creative Commons

Mion Ikegami,

Hikari Narabayashi,

Kazuaki Nakata

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 5, 2024

The role of the gut microbiota in gut-brain axis has attracted attention recent years. Some produces γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter mammals,

Language: Английский

Citations

1