The Overlapping Neurobiology of Induced and Pathological Anxiety: A Meta-Analysis of Functional Neural Activation

American Journal of Psychiatry, Год журнала: 2020, Номер 178(2), С. 156 - 164

Опубликована: Окт. 15, 2020

Although anxiety can be an adaptive response to unpredictable threats, pathological disorders occur when symptoms adversely affect daily life. Whether or not and share mechanisms remains unknown, but if they do, induced (adaptive) could used as intermediate translational model of improve drug development pipelines. The authors therefore compared meta-analyses functional neuroimaging studies anxiety.A systematic search the PubMed database was conducted in June 2019 for whole-brain MRI articles. Eligible articles contrasted either anxious patients control subjects unpredictable-threat condition a safe healthy participants. Five were included: posttraumatic stress disorder, social generalized panic specific phobia. A total 3,433 records identified, 181 met selection criteria, largest subset task type emotional (N=138). Seed-based d-mapping software all analyses.Induced (N=693 participants) (N=2,554 2,348 subjects) both showed increased activation left right insula (coordinates, 44, 14, -14 -38, 20, -8; k=2,102 k=1,305, respectively) cingulate cortex/medial prefrontal cortex (-12, -8, 68; k=2,217). When analyses split by phobia appeared most, disorder least, similar anxiety.This meta-analysis indicates consistent pattern across anxiety, supporting proposition that some neurobiological overlap former may latter. Induced might nevertheless better than others.

Язык: Английский

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The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network

Frontiers in Behavioral Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Фев. 24, 2021

The brain anxiety network is composed of a number interconnected cortical regions that detect threats and execute appropriate defensive responses via projections to the shell nucleus accumbens (NAcSh), dorsolateral region bed stria terminalis (BSTDL) lateral central amygdala (CeL). paraventricular thalamus (PVT) anatomically positioned integrate threat- arousal-related signals from cortex hypothalamus then relay these neural circuits in NAcSh, BSTDL, CeL mediate responses. This review describes anatomical connections PVT support view may be critical node network. Experimental findings are reviewed showing arousal peptides orexins (hypocretins) act at promote avoidance potential especially following exposure rats single episode footshocks. Recent experimental discussed which show neurons provide divergent subcortical behaviors projection NAcSh for enhanced social displayed exposed A theoretical model proposed how integrates hypothalamic modulate behavioral associated with other challenging situations.

Язык: Английский

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The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 151, С. 105237 - 105237

Опубликована: Май 18, 2023

Язык: Английский

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Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 152, С. 105305 - 105305

Опубликована: Июль 5, 2023

Язык: Английский

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Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament

Journal of Neuroscience, Год журнала: 2018, Номер 38(35), С. 7611 - 7621

Опубликована: Июль 30, 2018

Children with an extremely inhibited, anxious temperament (AT) are at increased risk for anxiety disorders and depression. Using a rhesus monkey model of early-life AT, we previously demonstrated that metabolism in the central extended amygdala (EAc), including nucleus (Ce) bed stria terminalis (BST), is associated trait-like variation AT. Here, use fMRI to examine relationships between Ce–BST functional connectivity AT large multigenerational family pedigree monkeys (n = 170 females 208 males). Results demonstrate heritable, accounts significant but modest portion variance coheritable Interestingly, AT-related BST were not correlated accounted non-overlapping Exploratory analyses suggest hypothalamus periaqueductal gray. Together, these results importance coordinated function within EAc determining individual differences brain regions its behavioral neuroendocrine components. SIGNIFICANCE STATEMENT Anxiety directly impact lives nearly one five people, accounting substantial worldwide suffering disability. nonhuman primate understand neurobiology underlying develop disorders. Leveraging same kinds neuroimaging measures routinely used human studies, activation with, coinherited Understanding how work together produce extreme provides neural target interventions promise preventing lifelong disability at-risk children.

Язык: Английский

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Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

eLife, Год журнала: 2019, Номер 8

Опубликована: Апрель 4, 2019

The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and anxiety, but specific factors that engage BNST defensive behaviors are unclear. Here we examined whether mediates freezing to stimuli (CSs) poorly predict onset aversive unconditioned (USs) rats. Reversible inactivation selectively reduced CSs signaled US (e.g., a backward CS followed US), did not eliminate forward even when they predicted USs variable intensity. Additionally, (but forward) increased Fos ventral BNST-projecting neurons infralimbic region medial prefrontal cortex (mPFC), hippocampus or amygdala. These data reveal circuits regulate unpredictable threats, which may be critical etiology expression anxiety.

Язык: Английский

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Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance

Proceedings of the National Academy of Sciences, Год журнала: 2020, Номер 117(42), С. 26406 - 26413

Опубликована: Окт. 5, 2020

Oxytocin increases the salience of both positive and negative social contexts it is thought that these diverse actions on behavior are mediated in part through circuit-specific action. This hypothesis based primarily manipulations oxytocin receptor function, leaving open question whether different populations neurons mediate effects behavior. Here we inhibited synthesis a stress-sensitive population specifically within medioventral bed nucleus stria terminalis (BNSTmv). knockdown prevented stress-induced vigilance decreases approach. Viral tracing BNSTmv revealed fibers regions controlling defensive behaviors, including lateral hypothalamus, anterior anteromedial BNST (BNSTam). infusion into BNSTam stress naïve mice increased reduced These results show extrahypothalamic plays key role anxiety behaviors.

Язык: Английский

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Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation

Journal of Neuroscience, Год журнала: 2020, Номер 40(41), С. 7949 - 7964

Опубликована: Сен. 21, 2020

When extreme, anxiety—a state of distress and arousal prototypically evoked by uncertain danger—can be debilitating. Uncertain anticipation is a shared feature situations that elicit signs symptoms anxiety across psychiatric disorders, species, assays. Despite the profound significance for human health wellbeing, neurobiology uncertain-threat remains unsettled. Leveraging paradigm adapted from animal research optimized fMRI signal decomposition, we examined neural circuits engaged during temporally certain threat in 99 men women. Results revealed systems recruited are anatomically colocalized frontocortical regions, extended amygdala, periaqueductal gray. Comparison conditions demonstrated this circuitry can fractionated, with regions showing relatively stronger engagement threat, amygdala reverse pattern. Although there widespread agreement bed nucleus stria terminalis dorsal amygdala—the two major subdivisions amygdala—play critical role orchestrating adaptive responses to potential danger, their precise contributions have remained contentious. Follow-up analyses these show statistically indistinguishable anticipation. These observations provide framework conceptualizing fear, understanding functional neuroanatomy humans, accelerating development more effective intervention strategies pathological anxiety. SIGNIFICANCE STATEMENT Anxiety—an emotion associated harm—has public health, yet underlying unclear. novel neuroimaging large sample, identify core circuit responsive both anticipation, fractionated into bias one kind or other. The occupies center stage neuropsychiatric models anxiety, but its architecture has Here demonstrate threat. Collectively, indicate need revise how think about fear.

Язык: Английский

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Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

Progress in brain research, Год журнала: 2019, Номер unknown, С. 375 - 436

Опубликована: Янв. 1, 2019

Язык: Английский

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Stress and central autonomic network

Autonomic Neuroscience, Год журнала: 2021, Номер 235, С. 102870 - 102870

Опубликована: Авг. 25, 2021

Язык: Английский

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