Biological Psychiatry, Год журнала: 2023, Номер 95(8), С. 810 - 817
Опубликована: Ноя. 14, 2023
Язык: Английский
eLife, Год журнала: 2020, Номер 9
Опубликована: Янв. 20, 2020
Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have been identified a clear need individualized intervention strategies, neurobiological substrates of ELA-attributable remain unknown due paucity translational investigations taking both development and into account. Male female rats exposed maternal separation ELA were analyzed anterograde tracing from basolateral amygdala (BLA) PFC identify sex-specific innervation trajectories through juvenility (PD28) adolescence (PD38;PD48). Resting-state functional connectivity (rsFC) was assessed longitudinally (PD28;PD48) separate cohort. All measures related anxiety-like behavior. ELA-exposed showed precocial maturation BLA-PFC innervation, females affected earlier than males. also disrupted rsFC, enduring relationships between rsFC This study is first providing anatomical evidence sex- experience-dependent corticolimbic development.
Язык: Английский
Процитировано
78
NeuroImage, Год журнала: 2021, Номер 235, С. 118017 - 118017
Опубликована: Март 29, 2021
Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination brain methods measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that highly similar to while simultaneously being more experimentally tractable, allowing visualization functional structural impact systematic perturbation. This review considers state art non-human primate with focus approaches can be combined neuroimaging. We consider both non-reversible (lesions) reversible temporary perturbations such electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, ultrasound based interference methods. Method-specific considerations from development community are offered facilitate this field support further innovations. conclude by identifying novel avenues for innovation highlighting clinical translational potential
Язык: Английский
Процитировано
70
American Journal of Psychiatry, Год журнала: 2022, Номер 179(7), С. 454 - 457
Опубликована: Июль 1, 2022
Язык: Английский
Процитировано
55
Personality Science, Год журнала: 2022, Номер 3
Опубликована: Окт. 12, 2022
Personality neuroscience is the study of persistent psychological individual differences, typically in general population, using neuroscientific methods. It has potential to shed light on neurobiological mechanisms underlying differences and their manifestation ongoing behavior experience. The field was inaugurated many decades ago, yet only really gained momentum last two, as suitable technologies have become widely available. employs a broad range methods, including molecular genetics, pharmacological assays or manipulations, electroencephalography, various neuroimaging modalities, such magnetic resonance imaging positron emission tomography. Although exciting progress being made this young field, much remains unknown. In brief review, we discuss discoveries that been made, methodological challenges advances, important questions remain be answered. We also best practices for personality research promising future directions field.
Язык: Английский
Процитировано
42
Frontiers in Neural Circuits, Год журнала: 2023, Номер 17
Опубликована: Апрель 5, 2023
Background Low intensity, transcranial focused ultrasound (tFUS) is a re-emerging brain stimulation technique with the unique capability of reaching deep structures non-invasively. Objective/Hypothesis We sought to demonstrate that tFUS can selectively and accurately target modulate in humans important for emotional functioning as well learning memory. hypothesized would result significant longitudinal changes perfusion targeted region selective modulation BOLD activity BOLD-based functional connectivity region. Methods In this study, we collected MRI before, simultaneously during, after two on different days sixteen healthy adults each serving their own control. Using arterial spin labeling (ASL) simultaneous blood oxygen level dependent (BOLD) MRI, found cerebral perfusion, regional specific regions amygdala entorhinal cortex (ErC). Results increased not contralateral homolog or either bilateral control Additionally, directly affected fashion without engaging auditory any analysis. Finally, resulted network connectivity. Conclusion neural connected networks. Lack findings suggests mechanism action due acoustic startle response but rather direct neuromodulatory process. Our suggest has potential future application novel therapy wide range neurological psychiatric disorders associated subcortical pathology.
Язык: Английский
Процитировано
33
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Авг. 12, 2023
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive avoidance, a trait that prevents learning through exposure. Although the origin of this failure is unclear, one candidate system involves control actions, coordinated lateral frontopolar cortex (FPl) via amygdala and sensorimotor connections. Using structural, functional, neurochemical evidence, we show how FPl-based action fails highly-anxious individuals. Their FPl overexcitable, as indexed by GABA/glutamate ratio at rest, receives stronger amygdalofugal projections than non-anxious male participants. Yet, high-anxious recruit during control, relying instead on dorsolateral medial prefrontal areas. This functional anatomical shift proportional excitability strength. The findings characterize circuit-level vulnerabilities anxious individuals, showing even mild challenges can saturate neural range, bottleneck tendencies.
Язык: Английский
Процитировано
26
Nature Mental Health, Год журнала: 2023, Номер 1(1), С. 12 - 24
Опубликована: Янв. 17, 2023
Язык: Английский
Процитировано
25
Cognitive Affective & Behavioral Neuroscience, Год журнала: 2024, Номер 24(2), С. 228 - 245
Опубликована: Фев. 14, 2024
Abstract Anxiety disorders affect millions of people worldwide and present a challenge in neuroscience research because their substantial heterogeneity clinical presentation. While great deal progress has been made understanding the neurobiology fear anxiety, these insights have not led to effective treatments. Understanding relationship between phenotypic underlying biology is critical first step solving this problem. We show translation, reverse computational modeling can contribute refined, cross-species anxiety as well disorders. More specifically, we outline how animal models be leveraged develop testable hypotheses humans by using targeted, approaches ethologically informed behavioral paradigms. discuss translational that guide prioritize nontraditional species. Finally, advocate for use harmonize cross-methodology into anxiety. Together, approach will help bridge widening gap currently conceptualize diagnose disorders, aid discovery better treatments conditions.
Язык: Английский
Процитировано
12
Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер 65(4), С. 538 - 567
Опубликована: Март 1, 2024
Depression is a serious public health problem, and adolescence an ‘age of risk’ for the onset Major Depressive Disorder. Recently, we others have proposed neuroimmune network models that highlight bidirectional communication between brain immune system in both mental physical health, including depression. These draw on research indicating cellular actors (particularly monocytes) signaling molecules cytokines) orchestrate inflammation periphery can directly modulate structure function brain. In brain, inflammatory activity heightens sensitivity to threats cortico‐amygdala circuit, lowers rewards cortico‐striatal alters executive control emotion regulation prefrontal cortex. When dysregulated, particularly under conditions chronic stress, generate feelings dysphoria, distress, anhedonia. This initiate unhealthy, self‐medicating behaviors (e.g. substance use, poor diet) manage which further heighten inflammation. Over time, dysregulation these circuits response may compound each other form positive feedback loop, whereby one organ exacerbates other. We suggest this dynamic joint vulnerability depression, during adolescence. three goals present paper. First, extend developmental framework risk depression Second, examine how perspective help explain high rates comorbidity psychiatric disorders across development, multimorbidity stress‐related medical illnesses. Finally, consider identifying pathways facilitate ‘next generation’ behavioral biological interventions target treat, ideally prevent, youth adolescents.
Язык: Английский
Процитировано
12
Human Brain Mapping, Год журнала: 2017, Номер 39(3), С. 1291 - 1312
Опубликована: Дек. 12, 2017
The central extended amygdala (EAc)-including the bed nucleus of stria terminalis (BST) and (Ce)-plays a critical role in triggering fear anxiety is implicated development range debilitating neuropsychiatric disorders. Although it widely believed that these disorders reflect coordinated activity distributed neural circuits, functional architecture EAc network degree to which BST Ce show distinct patterns connectivity unclear. Here, we used novel combination imaging approaches trace 130 healthy, racially diverse, community-dwelling adults. Multiband imaging, high-precision registration techniques, spatially unsmoothed data maximized anatomical specificity. Using newly developed seed regions, whole-brain regression analyses revealed robust between via sublenticular amygdala, ribbon subcortical gray matter encompassing ventral amygdalofugal pathway. Both regions displayed coupling with ventromedial prefrontal cortex (vmPFC), midcingulate (MCC), insula, anterior hippocampus. showed stronger thalamus, striatum, periaqueductal gray, several territories. only showing were neighboring dorsal amygdalohippocampal area, These observations provide baseline against compare special populations, inform our understanding normal pathological anxiety, showcase image techniques are likely be useful for researchers working "deidentified" neuroimaging data.
Язык: Английский
Процитировано
80