Neuropeptide-dependent spike time precision and plasticity in circadian output neurons DOI Creative Commons
Bryan Chong, Vipin Kumar, Dieu Linh Nguyen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Abstract Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, metabolism. output neurons are a group of that receive input from the central circadian clock located in suprachiasmatic nucleus mammalian brain transmit timing information to different regions body, coordinating processes. In Drosophila , an important set called pars intercerebralis (PI) neurons, which specific DN1. These can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) insect neuropeptides known activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep is not well understood. Here, we identify Dh31/Dh44-dependent spike time precision plasticity neurons. We find application synthesized affects membrane potential dynamics precise neuronal firing through their synergistic interaction, possibly mediated by calcium-activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide-dependent .

Язык: Английский

Neuropeptide‐Dependent Spike Time Precision and Plasticity in Circadian Output Neurons DOI Creative Commons
Bryan Chong, Vipin Kumar, Dieu Linh Nguyen

и другие.

European Journal of Neuroscience, Год журнала: 2025, Номер 61(5)

Опубликована: Март 1, 2025

ABSTRACT Circadian rhythms influence various physiological and behavioral processes such as sleep–wake cycles, hormone secretion, metabolism. In Drosophila , an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock DN1. These DN1 can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) are the insect neuropeptides known to activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep in not well understood. Here, we identify Dh31/Dh44‐dependent spike time precision plasticity neurons. We first find that a mixture enhanced firing compared application alone alone. next synthesized affects membrane potential dynamics precise timing neuronal through their synergistic interaction, possibly mediated by calcium‐activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide‐dependent .

Язык: Английский

Процитировано

0
Membrane-coated glass electrodes for stable, low-noise electrophysiology recordings in Drosophila central neurons DOI Creative Commons

Angelica T. Jameson,

Lucia K. Spera,

Dieu Linh Nguyen

и другие.

Journal of Neuroscience Methods, Год журнала: 2024, Номер 404, С. 110079 - 110079

Опубликована: Фев. 8, 2024

Язык: Английский

Процитировано

2
Neuropeptide-dependent spike time precision and plasticity in circadian output neurons DOI Creative Commons
Bryan Chong, Vipin Kumar, Dieu Linh Nguyen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Abstract Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, metabolism. output neurons are a group of that receive input from the central circadian clock located in suprachiasmatic nucleus mammalian brain transmit timing information to different regions body, coordinating processes. In Drosophila , an important set called pars intercerebralis (PI) neurons, which specific DN1. These can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) insect neuropeptides known activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep is not well understood. Here, we identify Dh31/Dh44-dependent spike time precision plasticity neurons. We find application synthesized affects membrane potential dynamics precise neuronal firing through their synergistic interaction, possibly mediated by calcium-activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide-dependent .

Язык: Английский

Процитировано

2