Neuropeptide-dependent spike time precision and plasticity in circadian output neurons DOI Creative Commons
Bryan Chong, Vipin Kumar, Dieu Linh Nguyen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, metabolism. output neurons are a group of that receive input from the central circadian clock located in suprachiasmatic nucleus mammalian brain transmit timing information to different regions body, coordinating processes. In Drosophila , an important set called pars intercerebralis (PI) neurons, which specific DN1. These can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) insect neuropeptides known activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep is not well understood. Here, we identify Dh31/Dh44-dependent spike time precision plasticity neurons. We find application synthesized affects membrane potential dynamics precise neuronal firing through their synergistic interaction, possibly mediated by calcium-activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide-dependent .

Language: Английский

Neuropeptide‐Dependent Spike Time Precision and Plasticity in Circadian Output Neurons DOI Creative Commons
Bryan Chong, Vipin Kumar, Dieu Linh Nguyen

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)

Published: March 1, 2025

ABSTRACT Circadian rhythms influence various physiological and behavioral processes such as sleep–wake cycles, hormone secretion, metabolism. In Drosophila , an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock DN1. These DN1 can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) are the insect neuropeptides known to activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep in not well understood. Here, we identify Dh31/Dh44‐dependent spike time precision plasticity neurons. We first find that a mixture enhanced firing compared application alone alone. next synthesized affects membrane potential dynamics precise timing neuronal through their synergistic interaction, possibly mediated by calcium‐activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide‐dependent .

Language: Английский

Citations

0
Membrane-coated glass electrodes for stable, low-noise electrophysiology recordings in Drosophila central neurons DOI Creative Commons

Angelica T. Jameson,

Lucia K. Spera,

Dieu Linh Nguyen

et al.

Journal of Neuroscience Methods, Journal Year: 2024, Volume and Issue: 404, P. 110079 - 110079

Published: Feb. 8, 2024

Language: Английский

Citations

2
Neuropeptide-dependent spike time precision and plasticity in circadian output neurons DOI Creative Commons
Bryan Chong, Vipin Kumar, Dieu Linh Nguyen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, metabolism. output neurons are a group of that receive input from the central circadian clock located in suprachiasmatic nucleus mammalian brain transmit timing information to different regions body, coordinating processes. In Drosophila , an important set called pars intercerebralis (PI) neurons, which specific DN1. These can further be subdivided into functionally anatomically distinctive anterior (DN1a) posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) 44 (Dh44) insect neuropeptides known activate PI control activity rhythms. However, neurophysiological basis how Dh31 Dh44 affect neural coding mechanisms underlying sleep is not well understood. Here, we identify Dh31/Dh44-dependent spike time precision plasticity neurons. We find application synthesized affects membrane potential dynamics precise neuronal firing through their synergistic interaction, possibly mediated by calcium-activated potassium channel conductance. Further, characterize Dh31/Dh44 enhances postsynaptic potentials Together, these results suggest multiplexed neuropeptide-dependent .

Language: Английский

Citations

2