IEEE Transactions on Neural Systems and Rehabilitation Engineering,
Год журнала:
2023,
Номер
32, С. 94 - 101
Опубликована: Дек. 8, 2023
Local
field
potential
(LFP)
recorded
by
sensing-enabled
neurostimulators
provided
chronic
observation
of
deep
brain
activities
for
the
research
disorders.
However,
contamination
from
electrocardiogram
(ECG)
deteriorated
extraction
effective
information
LFP.
This
study
proposed
a
novel
algorithm
based
on
minimizing
variance
combining
template
subtraction
to
improve
performance
ECG
artifact
removal
Four
patients
with
implanted
electrodes
were
recruited,
and
eight
real
LFP
records
collected
their
left
right
hemispheres,
respectively.
The
results
showed
that
method
improved
accuracy
peak
detection
in
LFP,
subsequent
signal
quality
after
compared
traditional
Pan-Tompkins
(PT)
method.
outcome
this
benefited
LFP-based
research,
promoting
application
more
areas.
Journal of Neurology,
Год журнала:
2022,
Номер
270(2), С. 1162 - 1177
Опубликована: Окт. 8, 2022
Deep
brain
stimulation
(DBS)
treatment
has
proven
effective
in
suppressing
symptoms
of
rigidity,
bradykinesia,
and
tremor
Parkinson's
disease.
Still,
patients
may
suffer
from
disabling
fluctuations
motor
non-motor
symptom
severity
during
the
day.
Conventional
DBS
consists
continuous
but
can
potentially
be
further
optimised
by
adapting
settings
to
presence
or
absence
through
closed-loop
control.
This
critically
relies
on
use
'physiomarkers'
extracted
(neuro)physiological
signals.
Ideal
physiomarkers
for
adaptive
(aDBS)
are
indicative
severity,
detectable
every
patient,
technically
suitable
implementation.
In
last
decades,
much
effort
been
put
into
detection
local
field
potential
(LFP)
their
clinical
practice.
We
conducted
a
research
synthesis
correlations
that
have
reported
between
LFP
signal
features
one
more
specific
PD
symptoms.
Features
based
spectral
beta
band
(~
13
30
Hz)
explained
~
17%
individual
variability
bradykinesia
rigidity
severity.
Limitations
oscillations
as
physiomarker
discussed,
strategies
improvement
aDBS
explored.
Brain stimulation,
Год журнала:
2024,
Номер
17(1), С. 125 - 133
Опубликована: Янв. 1, 2024
BackgroundDeep
brain
stimulation
(DBS)
is
an
invasive
treatment
option
for
patients
with
Parkinson's
disease.
Recently,
adaptive
DBS
(aDBS)
systems
have
been
developed,
which
adjust
timing
and
amplitude
in
real-time.
However,
it
unknown
how
changes
parameters,
movement
states
the
controllability
of
subthalamic
beta
activity
affect
aDBS
performance.ObjectiveTo
characterize
parameter
choice,
state
interactively
electrophysiological
behavioral
response
to
single
threshold
aDBS.MethodsWe
recorded
local
field
potentials
12
disease
receiving
acute
post-operative
state.
We
investigated
two
parameters:
onset
time
smoothing
real-time
power.
Electrophysiological
patterns
motor
performance
were
assessed
while
at
rest
during
a
simple
task.
further
studied
impact
on
by
comparing
without
power
modulation
continuous
stimulation.ResultsOur
findings
reveal
that
control
extent
suppression
achievable
rest.
Behavioral
data
indicate
only
specific
combinations
yield
beneficial
effect
aDBS.
During
movement,
action
induced
reduces
responsivity
closed
loop
algorithm.
demonstrate
prerequisite
effective
dependent
activity.ConclusionOur
results
highlight
interaction
between
selection,
driving
performance.
By
this
means,
we
identify
directions
development
closed-loop
algorithms.
Deep Brain Stimulation,
Год журнала:
2023,
Номер
2, С. 1 - 5
Опубликована: Май 16, 2023
ObjectivesParkinson
patients
with
chronic
DBS
routinely
receive
sensing-enabled
implantable
pulse
generators
upon
battery
replacement.
Here
we
aimed
to
assess
whether
and/or
how
local
field
potential
based
reprogramming
may
be
of
use
in
this
population.MethodsIn
four
Parkinson
on
treatment
bilateral
STN-DBS
and
implanted
the
Percept™
PC
generator,
employed
an
approach
select
stimulation
contacts
amplitudes
beta-activity.
When
applicable,
effect
parameter
adjustments
effectiveness
DBS-induced
side
effects
was
assessed.ResultsIn
one
out
eight
electrodes,
LFP-guided
contact
different
from
clinically
determined
one.
Beta-based
therapeutic
windows
could
defined
five
electrodes.
were
performed
two
patients,
resulting
improved
motor
fluctuations
decreased
stimulation-induced
respectively.DiscussionLFP-guided
has
improve
decrease
selected
cases.
Prospective
controlled
research
is
required
clinical
usefulness
reprogramming.
Clinical Neurophysiology,
Год журнала:
2022,
Номер
146, С. 147 - 161
Опубликована: Дек. 2, 2022
Local
field
potential
(LFP)
recordings
from
deep
brain
stimulation
(DBS)
electrodes
are
often
contaminated
with
electrocardiographic
(ECG)
artifacts
that
hinder
the
detection
of
disease-specific
electrical
activity.Three
ECG
suppression
methods
were
evaluated:
(1)
QRS
interpolation
Perceive
toolbox,
(2)
template
subtraction,
and
(3)
singular
value
decomposition
(SVD).
LFPs
recorded
Medtronic
PerceptTM
PC
system
in
nine
Parkinson's
disease
patients
OFF
("OFF-DBS";
anode
disconnected)
ON
at
0
mA
("ON-DBS
mA";
connected).
Findings
verified
simulated
ECG-contaminated
time
series.ECG
present
10
out
18
ON-DBS
recordings.
All
drastically
reduced
artifact-induced
beta
band
(13-35
Hz)
power
least
partly
recovered
peak
burst
dynamics.
Using
external
lengthening
artifact
epoch
length
improved
performance
methods.
Increasing
length,
however,
elevated
risk
flattening
losing
dynamics.The
SVD
method
formed
preferred
trade-off
between
cleaning
signal
loss,
as
long
its
parameter
settings
adequately
chosen.ECG
enable
analysis
neural
activity
signals
affected
by
artifacts.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 5, 2024
Neuropsychiatric
symptoms
are
common
and
disabling
in
Parkinson's
disease
(PD),
with
troublesome
anxiety
occurring
one-third
of
patients.
Management
PD
is
challenging,
hampered
by
insufficient
insight
into
underlying
mechanisms,
lack
objective
measurements,
largely
ineffective
treatments.In
this
study,
we
assessed
the
intracranial
neurophysiological
correlates
patients
treated
deep
brain
stimulation
(DBS)
laboratory
at
home.
We
hypothesized
that
low-frequency
(theta-alpha)
activity
would
be
associated
anxiety.
npj Parkinson s Disease,
Год журнала:
2024,
Номер
10(1)
Опубликована: Авг. 9, 2024
Abstract
Oscillatory
activity
within
the
beta
frequency
range
(13–30
Hz)
serves
as
a
Parkinson’s
disease
biomarker
for
tailoring
deep
brain
stimulation
(DBS)
treatments.
Currently,
identifying
clinically
relevant
signals,
specifically
frequencies
of
peak
amplitudes
spectral
band,
is
subjective
process.
To
inform
potential
strategies
objective
clinical
decision
making,
we
assessed
algorithms
peaks
and
devised
standardized
approach
both
research
applications.
Employing
novel
monopolar
referencing
strategy,
utilized
sensing
device
to
measure
power
across
distinct
contacts
along
each
DBS
electrode
implanted
in
subthalamic
nucleus.
We
then
evaluated
accuracy
ten
detection
against
benchmark
established
by
expert
consensus.
The
most
accurate
algorithms,
all
sharing
similar
underlying
algebraic
dynamic
amplitude
thresholding
approaches,
matched
consensus
performance
reliably
predicted
parameters
during
follow-up
visits.
These
findings
highlight
algorithmic
solutions
overcome
bias
identification,
presenting
viable
options
standardizing
this
Such
advancements
could
lead
significant
improvements
efficiency
patient-specific
therapy
parameterization.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
Although
high-frequency
deep
brain
stimulation
(DBS)
is
effective
at
relieving
many
motor
symptoms
of
Parkinson’s
disease
(PD),
its
effects
on
gait
can
be
variable
and
unpredictable.
This
due
to
1)
a
lack
standardized
robust
metrics
for
assessment
in
PD
patients,
2)
the
challenges
performing
thorough
evaluation
all
parameters
space
that
alter
gait,
3)
understanding
impacts
neurophysiological
signatures
walking.
In
this
study,
our
goal
was
develop
data-driven
approach
identify
optimal,
personalized
DBS
improve
patients
signature
improved
gait.
Local
field
potentials
from
globus
pallidus
electrocorticography
cortex
three
were
recorded
using
an
implanted
bidirectional
neural
stimulator
during
overground
A
walking
performance
index
(WPI)
developed
assess
with
high
reliability.
frequency,
amplitude,
pulse
width
“clinically-optimized”
contact
then
systemically
changed
study
their
underlying
dynamics.
We
Gaussian
Process
Regressor
(GPR)
model
map
relationship
between
settings
WPI.
Using
model,
we
identified
validated
significantly
metrics.
Linear
mixed
models
employed
spectral
features
associated
enhanced
performance.
demonstrated
linked
modulation
activity
specific
frequency
bands,
reduced
beta
band
power
pallidum
increased
alpha
pallidal-motor
coherence
synchronization
key
moments
cycle.
Integrating
WPI
GPR
optimize
underscores
importance
developing
personalized,
interventions
improvement
PD.
Neuromodulation Technology at the Neural Interface,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
ObjectivesInitial
deep
brain
stimulation
(DBS)
programming
using
a
monopolar
review
is
time-consuming,
subjective,
and
burdensome.
Incorporating
neurophysiology
has
the
potential
to
expedite,
objectify,
automatize
initial
DBS
programming.
We
aimed
assess
feasibility
performance
of
clinically
implemented
sensing-based
for
Parkinson's
disease
(PD).Materials
MethodsWe
conducted
single-center
retrospective
study
in
15
patients
with
PD
(25
hemispheres)
implanted
sensing-enabled
neurostimulator
whom
subthalamic
nucleus/globus
pallidus
pars
interna
was
guided
by
beta
power
real-time
local
field
recordings,
instead
review.ResultsThe
visit
lasted
on
average
42.2
minutes
(SD
18)
per
hemisphere.
During
optimization
phase,
conventional
clinical
not
required
any
patients.
The
contact
level
remained
same
at
final
follow-up
all
hemispheres
except
three.
amplitude
0.8
mA
0.9)
higher
than
initially
set
after
original
visit.
One
year
surgery,
off-medication
International
Parkinson
Movement
Disorder
Society
Unified
Disease
Rating
Scale
(MDS-UPDRS)
III
total
score,
tremor
subscore,
MDS-UPDRS
IV,
levodopa-equivalent
dose
improved
47.0%
(p
<
0.001),
77.7%
=
51.1%
0.006),
44.8%
0.011)
compared
preoperatively
this
approach.ConclusionsThis
shows
that
feasible
rapid,
selected
effective
contacts
most
patients,
including
those
tremor.
Technologic
innovations
practical
developments
could
improve