Changes in high-frequency aperiodic 1/f slope and periodic activity reflect post-stimulus functional inhibition in the visual cortex

Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 24

Опубликована: Апрель 1, 2024

Abstract It has been shown that cessation of intensive sensory stimulation is associated with a transient increase in functional inhibition the cortical areas. However, electrophysiological correlates this post-stimulus human brain have not thoroughly investigated. To investigate inhibition, we analyzed magnetoencephalogram (MEG) recorded at rest and after visual varying intensity (high-contrast gratings drifting slow, medium, or high rate) 25 healthy women aged 18–40 years. We condition- intensity-related changes MEG parameters sensitive to inhibition: periodic alpha-beta power, peak alpha frequency (PAF), 1/f aperiodic slope. also investigated association these sensitivity avoidance assessed by questionnaire. evaluate influence hormonal status on studied parameters, participants were examined twice, during follicular luteal phases menstrual cycle (MC). Regardless MC phase, increasing drift rate resulted proportional posterior PAF, negative shift (1/f) slope power spectrum high-frequency range. Compared rest, periods characterized higher more areas, widespread beta power. While drift-rate-dependent modulations correlated, PAF did correlate either them. A greater intensity-dependent predicted subjective sensitivity/avoidance, suggesting stronger regulatory top-down modulation cortex individuals heightened sensitivity. Our results show several concordantly indicate enhancement preceding stimulation. may share some common mechanisms, reflect distinct aspect inhibitory regulation. inform potential inhibition-based biomarkers for clinical translational research.

Язык: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

Опубликована: Янв. 6, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

Опубликована: Март 13, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

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Cross brain reshaping in congenital visual or hearing impairment: triple-network dysfunction

Brain Communications, Год журнала: 2025, Номер 7(2)

Опубликована: Янв. 1, 2025

Abstract This research examines how congenital visual or hearing impairment reshapes brain function using EEG. The study involved 40 children with impairment, and 42 age gender-matched normal as controls. investigation included assessments of auditory abilities, along comprehensive EEG evaluations. Techniques such source localization, functional connectivity cross-frequency coupling were used to analyse variations in activity. Machine learning methods, specifically support vector machines, utilized identify key reshaping characteristics associated impairments. Results showed reduced activation the cortex for visually impaired decreased hearing-impaired compared control group. Both groups demonstrated significant reductions across various regions, including cortices, insula, parahippocampal gyrus, posterior cingulate gyrus frontal cortex. machine model highlighted aberrant between visual/auditory right medial prefrontal dorsolateral these impairments alpha frequency band. Spatially similar patterns rhythmic activity also observed. concludes that significantly impact development, identifying distinct shared patterns. consistent presence dysrhythmic suggest existence a triple network anomaly.

Язык: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

eLife, Год журнала: 2025, Номер 13

Опубликована: Май 16, 2025

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent, and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I 10 individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence on early visual humans. First, participants underwent MRS scanning at rest with their eyes open closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, ratio, respectively. Subsequently, EEG was recorded assess aperiodic activity (1–20 Hz) a neurophysiological measure during flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

Опубликована: Июнь 5, 2024

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent, and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, sight recovery demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We interpret these findings resulting from increased consequence which required commensurately restored input provided additional excitation.

Язык: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

eLife, Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

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Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 22, 2024

ABSTRACT Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) electroencephalography (EEG) markers cortical E/I ten individuals who had been treated for dense bilateral congenital cataracts, after an average 12 years blindness, test dependence humans on early visual experience. First, participants underwent MRS scanning at rest with their eyes opened closed, obtain cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration Glx/GABA+, as measures inhibition, excitation, respectively. Subsequently, EEG was recorded assess aperiodic activity (1-20 Hz) a neurophysiological measure ratio, during open flickering stimulation. Across conditions, cataract-reversal demonstrated significantly lower Glx/GABA+ higher intercept steeper slope occipital electrodes, compared age-matched sighted controls. In group, associated better acuity, Glx correlated positively conditions input. We speculate these findings result from increased consequence which might require commensurately order balance additional restored The would thus be homeostatic plasticity.

Язык: Английский

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Experience dependence of alpha rhythms and neural dynamics in mouse visual cortex

Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. e2011222024 - e2011222024

Опубликована: Авг. 16, 2024

The role of experience in the development and maintenance emergent network properties such as cortical oscillations states is poorly understood. To define how early-life affects dynamics visual cortex adult, head-fixed mice, we examined effects two forms blindness initiated before eye-opening continuing through recording adulthood: (1) bilateral loss retinal input (enucleation) (2) degradation (eyelid-suture). Neither form deprivation fundamentally altered state-dependent regulation firing-rates or local field potentials. However, each did cause a unique set changes behavior. Laminar analysis revealed different generative mechanisms for low-frequency synchronization, one prevalent during movement, other quiet-wakefulness. former was absent enucleated suggesting mouse homolog human alpha oscillations. In addition, neurons animals were less correlated fired more regularly, but showed no change mean firing-rate. Chronic lid-suture decreased firing rates quiet-wakefulness, not with effect on neural correlations regularity. Sutured broadband increase dEEG power an increased occurrence, reduced central frequency, narrowband gamma complementary--rather than additive--effects enucleation suggest that these does require vision plastic to modified input. Our results complex interaction internal set-points determines expression mature activity, synchronization being particularly susceptible early deprivation. Significance statement developmental rules guide balances homeostatic points external inputs establish level critical its function are unclear. Using multiple methods deprivation, show dependent type Rather, specific rhythms, firing-rate points, differentially by experience. deprivations identify rhythm likely mechanism blindness. advance our understanding regulatory leading normal processing, which disorders.

Язык: Английский

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Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

Abstract Background American tackle football is associated with high rates of concussion, leading to neurophysiological disturbances and debilitating clinical symptoms. Previous investigations the effects concussion have largely ignored aperiodic activity, which a marker cortical excitability. Purpose We examined whether during season school related changes in periodic activity any such are outcomes. Materials Methods Pre- post-season resting-state magnetoencephalography (MEG) data were collected from 91 players over as many four seasons play, for total 278 collections. During these cohort 10 individuals diagnosed concussion. MEG source-imaged, frequency-transformed parameterized, linear mixed models used examine on pre-to-post-season activity. Scores Post-Concussive Symptom Inventory correlated determine their relevance. Results Concussion was increased exponents superior frontal cortices, indicating relative reduction This slowing neurophysiology mediated raw delta gamma power worse cognitive concerns across participants. Pre-to-post-season aperiodic-corrected alpha theta rhythmic also decreased posterior cortices concussed players. Conclusion These findings indicate that alters both excitability signaling cortex, differing spatial topographies implications Key reduces cortices. accounts canonical power. Concussion-related symptom severity.

Язык: Английский

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