Annual Review of Cell and Developmental Biology,
Год журнала:
2007,
Номер
23(1), С. 375 - 404
Опубликована: Июнь 25, 2007
Neuronal
motility
is
a
fundamental
feature
that
underlies
the
development,
regeneration,
and
plasticity
of
nervous
system.
Two
major
developmental
events--directed
migration
neuronal
precursor
cells
to
proper
positions
guided
elongation
axons
their
target
cells--depend
on
large-scale
motility.
At
finer
scale,
also
manifested
in
many
aspects
structures
functions,
ranging
from
differentiation
refinement
axonal
dendritic
morphology
during
development
synapse
remodeling
associated
with
learning
memory
adult
brain.
As
primary
second
messenger
conveys
cytoplasmic
actions
electrical
activity
neuroactive
ligands,
Ca(2+)
plays
central
role
regulation
Recent
studies
have
revealed
common
Ca(2+)-dependent
signaling
pathways
are
deployed
for
regulating
cytoskeletal
dynamics
migration,
axon
dendrite
synaptic
plasticity.
Cytogenetic and Genome Research,
Год журнала:
2015,
Номер
146(2), С. 89 - 99
Опубликована: Янв. 1, 2015
22q11.2
deletion
syndrome
(22q11.2DS)
is
the
most
common
genetic
associated
with
schizophrenia.
The
catechol-O-methyltransferase
(COMT)
gene
located
in
obligatory
region,
and
possible
associations
between
COMT
variants
neuropsychiatric
manifestations
22q11.2DS
have
been
reported.
purpose
of
current
study
was
to
evaluate
effect
hemizygosity
molecular
haplotypes
on
expression
enzyme
activity
its
association
psychotic
symptoms
22q11.2DS.
Annual Review of Neuroscience,
Год журнала:
2008,
Номер
31(1), С. 563 - 590
Опубликована: Июнь 17, 2008
Sensory
experience
and
the
resulting
synaptic
activity
within
brain
are
critical
for
proper
development
of
neural
circuits.
Experience-driven
causes
membrane
depolarization
calcium
influx
into
select
neurons
a
circuit,
which
in
turn
trigger
wide
variety
cellular
changes
that
alter
connectivity
circuit.
One
way
leads
to
remodeling
synapses
made
by
is
through
activation
new
gene
transcription.
Recent
studies
have
identified
many
signaling
pathways
link
neuronal
transcription,
revealing
both
transcription
factors
mediate
this
process
activity-regulated
genes.
These
indicate
regulates
complex
program
expression
involved
aspects
development,
including
dendritic
branching,
synapse
maturation,
elimination.
Genetic
mutations
several
key
regulators
activity-dependent
give
rise
neurological
disorders
humans,
suggesting
future
will
likely
provide
insight
mechanisms
disruption
can
disorders.
Proceedings of the National Academy of Sciences,
Год журнала:
2008,
Номер
105(26), С. 9093 - 9098
Опубликована: Июнь 25, 2008
Activity-regulated
gene
expression
is
believed
to
play
a
key
role
in
the
development
and
refinement
of
neuronal
circuitry.
Nevertheless,
transcriptional
networks
that
regulate
synapse
growth
plasticity
remain
largely
uncharacterized.
Here,
we
show
microRNA
132
(miR132)
an
activity-dependent
rapid
response
regulated
by
cAMP
element-binding
(CREB)
protein
pathway.
Introduction
miR132
into
hippocampal
neurons
enhanced
dendrite
morphogenesis
whereas
inhibition
2'O-methyl
RNA
antagonists
blocked
these
effects.
Furthermore,
activity
inhibited
translation
p250GAP,
target,
siRNA-mediated
knockdown
p250GAP
mimicked
miR132-induced
growth.
Experiments
using
dominant-interfering
mutants
suggested
Rac
signaling
downstream
p250GAP.
We
propose
miR132-p250GAP
pathway
plays
structural
functional
plasticity.
