Wnt Signaling in Neural Circuit Assembly DOI
Patricia C. Salinas, Yimin Zou

Annual Review of Neuroscience, Journal Year: 2008, Volume and Issue: 31(1), P. 339 - 358

Published: June 17, 2008

The Wnt family of secreted proteins plays a crucial role in nervous system wiring. Wnts regulate neuronal positioning, polarization, axon and dendrite development, synaptogenesis. These diverse roles are due not only to the large numbers ligands receptors but also their ability signal through distinct signaling pathways different cell types developmental contexts. Studies on have shed new light novel molecular mechanisms that control development complex connections. This review discusses recent advances how influences aspects circuit assembly changes gene expression and/or cytoskeletal modulation.

Language: Английский

22q11.21 Deletion Syndromes: A Review of Proximal, Central, and Distal Deletions and Their Associated Features DOI Open Access

Doron Gothelf,

Amanda J. Law,

Amos Frisch

et al.

Cytogenetic and Genome Research, Journal Year: 2015, Volume and Issue: 146(2), P. 89 - 99

Published: Jan. 1, 2015

22q11.2 deletion syndrome (22q11.2DS) is the most common genetic associated with schizophrenia. The catechol-O-methyltransferase (COMT) gene located in obligatory region, and possible associations between COMT variants neuropsychiatric manifestations 22q11.2DS have been reported. purpose of current study was to evaluate effect hemizygosity molecular haplotypes on expression enzyme activity its association psychotic symptoms 22q11.2DS.

Language: Английский

Citations

1891
Culturing hippocampal neurons. DOI Open Access
Hidekazu Tanaka

Folia Pharmacologica Japonica, Journal Year: 2002, Volume and Issue: 119(3), P. 163 - 166

Published: Jan. 1, 2002

分子生物学の手法が進歩し，遺伝子操作したマウスで，生体内での分子の意味を直接探ることも可能な昨今である．そんななかin vitroの培養系を用いてわざわざ人工的·非生理的な条件で研究をするのはなぜかとのお叱りもあろうかと想像する．だが，培養ニューロンは比較的均一な系であり，極端な状態を作り出すことが可能なので，生体内では観察するのが困難な現象も抽出しうる可能性がある．私はそう考えて，培養ニューロンを比較的幅広い目的に用いる努力をしている．

Citations

1149
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior DOI Creative Commons
J. Tiago Gonçalves, Simon T. Schafer, Fred H. Gage

et al.

Cell, Journal Year: 2016, Volume and Issue: 167(4), P. 897 - 914

Published: Nov. 1, 2016

Language: Английский

Citations

968
Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation DOI Creative Commons
Zhaolan Zhou, Elizabeth J. Hong, Sonia Cohen

et al.

Neuron, Journal Year: 2006, Volume and Issue: 52(2), P. 255 - 269

Published: Oct. 1, 2006

Language: Английский

Citations

827
Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System DOI
Steven W. Flavell, Michael E. Greenberg

Annual Review of Neuroscience, Journal Year: 2008, Volume and Issue: 31(1), P. 563 - 590

Published: June 17, 2008

Sensory experience and the resulting synaptic activity within brain are critical for proper development of neural circuits. Experience-driven causes membrane depolarization calcium influx into select neurons a circuit, which in turn trigger wide variety cellular changes that alter connectivity circuit. One way leads to remodeling synapses made by is through activation new gene transcription. Recent studies have identified many signaling pathways link neuronal transcription, revealing both transcription factors mediate this process activity-regulated genes. These indicate regulates complex program expression involved aspects development, including dendritic branching, synapse maturation, elimination. Genetic mutations several key regulators activity-dependent give rise neurological disorders humans, suggesting future will likely provide insight mechanisms disruption can disorders.

Language: Английский

Citations

801
Branching out: mechanisms of dendritic arborization DOI
Yuh Nung Jan, Lily Yeh Jan

Nature reviews. Neuroscience, Journal Year: 2010, Volume and Issue: 11(5), P. 316 - 328

Published: April 20, 2010

Language: Английский

Citations

686
From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function DOI Creative Commons
Paul L. Greer, Michael E. Greenberg

Neuron, Journal Year: 2008, Volume and Issue: 59(6), P. 846 - 860

Published: Sept. 1, 2008

Language: Английский

Citations

634
Emerging roles of Wnts in the adult nervous system DOI
Nibaldo C. Inestrosa, Ernest Arenas

Nature reviews. Neuroscience, Journal Year: 2009, Volume and Issue: 11(2), P. 77 - 86

Published: Dec. 16, 2009

Language: Английский

Citations

593
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity DOI Creative Commons
Gary A. Wayman, Yong‐Seok Lee, Hiroshi Tokumitsu

et al.

Neuron, Journal Year: 2008, Volume and Issue: 59(6), P. 914 - 931

Published: Sept. 1, 2008

Language: Английский

Citations

549
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP DOI Open Access
Gary A. Wayman, Monika A. Davare,

Hideaki Ando

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2008, Volume and Issue: 105(26), P. 9093 - 9098

Published: June 25, 2008

Activity-regulated gene expression is believed to play a key role in the development and refinement of neuronal circuitry. Nevertheless, transcriptional networks that regulate synapse growth plasticity remain largely uncharacterized. Here, we show microRNA 132 (miR132) an activity-dependent rapid response regulated by cAMP element-binding (CREB) protein pathway. Introduction miR132 into hippocampal neurons enhanced dendrite morphogenesis whereas inhibition 2'O-methyl RNA antagonists blocked these effects. Furthermore, activity inhibited translation p250GAP, target, siRNA-mediated knockdown p250GAP mimicked miR132-induced growth. Experiments using dominant-interfering mutants suggested Rac signaling downstream p250GAP. We propose miR132-p250GAP pathway plays structural functional plasticity.

Language: Английский

Citations

544