Advances in Genomics and Genetics,
Год журнала:
2015,
Номер
unknown, С. 131 - 131
Опубликована: Март 1, 2015
Eating
disorders
(EDs)
are
serious
psychiatric
conditions
influenced
by
biological,
psychological,
and
sociocultural
factors.
A
better
understanding
of
the
genetics
these
complex
traits
development
more
sophisticated
molecular
biology
tools
have
advanced
our
etiology
EDs.
The
aim
this
review
is
to
critically
evaluate
literature
on
genetic
research
conducted
three
major
EDs:
anorexia
nervosa
(AN),
bulimia
(BN),
binge
eating
disorder
(BED).
We
will
first
diagnostic
criteria,
clinical
features,
prevalence,
prognosis
AN,
BN,
BED,
followed
a
family,
twin,
adoption
studies.
then
history
studies
EDs
covering
linkage
analysis,
candidate
gene
association
studies,
genome-wide
study
rare
variants
in
Our
also
incorporates
translational
perspective
animal
models
ED-related
phenotypes.
Finally,
we
nascent
field
epigenetics
look
forward
future
directions
for
ED
research.
The Annual Review of Pharmacology and Toxicology,
Год журнала:
2011,
Номер
53(1), С. 59 - 87
Опубликована: Март 3, 2011
Epigenetic
mechanisms,
which
control
chromatin
structure
and
function,
mediate
changes
in
gene
expression
that
occur
response
to
diverse
stimuli.
Recent
research
has
established
environmental
events
behavioral
experience
induce
epigenetic
at
particular
loci
these
help
shape
neuronal
plasticity
function
hence
behavior.
Some
of
can
be
stable
even
persist
for
a
lifetime.
Increasing
evidence
supports
the
hypothesis
aberrations
remodeling
subsequent
effects
on
within
limbic
brain
regions
contribute
pathogenesis
depression
other
stress-related
disorders
such
as
post-traumatic
stress
disorder
anxiety
syndromes.
Likewise,
gradually
developing
but
persistent
therapeutic
antidepressant
medications
may
achieved
part
via
mechanisms.
This
review
discusses
recent
advances
our
understanding
regulation
focuses
three
distinct
aspects
stress-induced
pathology:
treatment
during
adulthood,
lifelong
early-life
vulnerability,
possible
transgenerational
transmission
abnormalities.
Advances in Genomics and Genetics,
Год журнала:
2015,
Номер
unknown, С. 131 - 131
Опубликована: Март 1, 2015
Eating
disorders
(EDs)
are
serious
psychiatric
conditions
influenced
by
biological,
psychological,
and
sociocultural
factors.
A
better
understanding
of
the
genetics
these
complex
traits
development
more
sophisticated
molecular
biology
tools
have
advanced
our
etiology
EDs.
The
aim
this
review
is
to
critically
evaluate
literature
on
genetic
research
conducted
three
major
EDs:
anorexia
nervosa
(AN),
bulimia
(BN),
binge
eating
disorder
(BED).
We
will
first
diagnostic
criteria,
clinical
features,
prevalence,
prognosis
AN,
BN,
BED,
followed
a
family,
twin,
adoption
studies.
then
history
studies
EDs
covering
linkage
analysis,
candidate
gene
association
studies,
genome-wide
study
rare
variants
in
Our
also
incorporates
translational
perspective
animal
models
ED-related
phenotypes.
Finally,
we
nascent
field
epigenetics
look
forward
future
directions
for
ED
research.
