Genetics and epigenetics of eating disorders DOI Open Access
Cynthia M. Bulik, Zeynep Yılmaz,

Andrew J. Hardaway

et al.

Advances in Genomics and Genetics, Journal Year: 2015, Volume and Issue: unknown, P. 131 - 131

Published: March 1, 2015

Eating disorders (EDs) are serious psychiatric conditions influenced by biological, psychological, and sociocultural factors. A better understanding of the genetics these complex traits development more sophisticated molecular biology tools have advanced our etiology EDs. The aim this review is to critically evaluate literature on genetic research conducted three major EDs: anorexia nervosa (AN), bulimia (BN), binge eating disorder (BED). We will first diagnostic criteria, clinical features, prevalence, prognosis AN, BN, BED, followed a family, twin, adoption studies. then history studies EDs covering linkage analysis, candidate gene association studies, genome-wide study rare variants in Our also incorporates translational perspective animal models ED-related phenotypes. Finally, we nascent field epigenetics look forward future directions for ED research.

Language: Английский

Genome-wide identification and characterization of functional neuronal activity–dependent enhancers DOI
Athar N. Malik, Thomas Vierbuchen, Martin Hemberg

et al.

Nature Neuroscience, Journal Year: 2014, Volume and Issue: 17(10), P. 1330 - 1339

Published: Sept. 7, 2014

Language: Английский

Citations

265
Epigenetic Mechanisms of Depression and Antidepressant Action DOI
Vincent Vialou, Jian Feng, Alfred J. Robison

et al.

The Annual Review of Pharmacology and Toxicology, Journal Year: 2011, Volume and Issue: 53(1), P. 59 - 87

Published: March 3, 2011

Epigenetic mechanisms, which control chromatin structure and function, mediate changes in gene expression that occur response to diverse stimuli. Recent research has established environmental events behavioral experience induce epigenetic at particular loci these help shape neuronal plasticity function hence behavior. Some of can be stable even persist for a lifetime. Increasing evidence supports the hypothesis aberrations remodeling subsequent effects on within limbic brain regions contribute pathogenesis depression other stress-related disorders such as post-traumatic stress disorder anxiety syndromes. Likewise, gradually developing but persistent therapeutic antidepressant medications may achieved part via mechanisms. This review discusses recent advances our understanding regulation focuses three distinct aspects stress-induced pathology: treatment during adulthood, lifelong early-life vulnerability, possible transgenerational transmission abnormalities.

Language: Английский

Citations

263
Disruption of an EHMT1-Associated Chromatin-Modification Module Causes Intellectual Disability DOI Creative Commons
Tjitske Kleefstra, Jamie M. Kramer, Kornelia Neveling

et al.

The American Journal of Human Genetics, Journal Year: 2012, Volume and Issue: 91(1), P. 73 - 82

Published: June 21, 2012

Language: Английский

Citations

248
Chronic Pain: Emerging Evidence for the Involvement of Epigenetics DOI Creative Commons
Franziska Denk, Stephen B. McMahon

Neuron, Journal Year: 2012, Volume and Issue: 73(3), P. 435 - 444

Published: Feb. 1, 2012

Language: Английский

Citations

245
Genetics and epigenetics of eating disorders DOI Open Access
Cynthia M. Bulik, Zeynep Yılmaz,

Andrew J. Hardaway

et al.

Advances in Genomics and Genetics, Journal Year: 2015, Volume and Issue: unknown, P. 131 - 131

Published: March 1, 2015

Eating disorders (EDs) are serious psychiatric conditions influenced by biological, psychological, and sociocultural factors. A better understanding of the genetics these complex traits development more sophisticated molecular biology tools have advanced our etiology EDs. The aim this review is to critically evaluate literature on genetic research conducted three major EDs: anorexia nervosa (AN), bulimia (BN), binge eating disorder (BED). We will first diagnostic criteria, clinical features, prevalence, prognosis AN, BN, BED, followed a family, twin, adoption studies. then history studies EDs covering linkage analysis, candidate gene association studies, genome-wide study rare variants in Our also incorporates translational perspective animal models ED-related phenotypes. Finally, we nascent field epigenetics look forward future directions for ED research.

Language: Английский

Citations

239