Distinct extended amygdala circuits for divergent motivational states

Nature, Год журнала: 2013, Номер 496(7444), С. 224 - 228

Опубликована: Март 19, 2013

Язык: Английский

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A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications

Frontiers in Behavioral Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Июль 3, 2018

Stress is recognized as an important issue in basic and clinical neuroscience research, based upon the founding historical studies by Walter Canon Hans Selye past century, when concept of stress emerged a biological adaptive perspective. A lot research after that period has expanded knowledge field. Since then, it was discovered response to stressful stimuli elaborated triggered the, now known, system, which integrates wide diversity brain structures that, collectively, are able detect events interpret them real or potential threats. However, different types stressors engage networks, requiring fine-tuned functional neuroanatomical processing. This integration information from stressor itself may result rapid activation Sympathetic-Adreno-Medullar (SAM) axis Hypothalamus-Pituitary-Adrenal (HPA) axis, two major components involved response. The complexity not restricted neuroanatomy SAM HPA axes mediators, but also diverge according timing duration exposure, well its short- and/or long-term consequences. identification neuronal circuits stress, their interaction with mediator molecules over time critical, only for understanding physiological responses, understand implications on mental health.

Язык: Английский

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Updating dopamine reward signals

Current Opinion in Neurobiology, Год журнала: 2012, Номер 23(2), С. 229 - 238

Опубликована: Дек. 22, 2012

Recent work has advanced our knowledge of phasic dopamine reward prediction error signals. The signal is bidirectional, reflects well the higher order described by temporal difference learning models, compatible with model-free and model-based reinforcement learning, reports subjective rather than physical value during discounting stimulus perception aspects. Dopamine activations are primarily driven reward, to some extent risk, whereas punishment salience have only limited activating effects when appropriate controls respected. homogeneous in terms time course but heterogeneous many other It essential for synaptic plasticity a range behavioural situations.

Язык: Английский

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Activation of VTA GABA Neurons Disrupts Reward Consumption

Neuron, Год журнала: 2012, Номер 73(6), С. 1184 - 1194

Опубликована: Март 1, 2012

Язык: Английский

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CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

Neuron, Год журнала: 2015, Номер 87(3), С. 605 - 620

Опубликована: Июль 23, 2015

Язык: Английский

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Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

Nature Neuroscience, Год журнала: 2012, Номер 15(8), С. 1105 - 1107

Опубликована: Июнь 24, 2012

Язык: Английский

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Lateral hypothalamic circuits for feeding and reward

Nature Neuroscience, Год журнала: 2016, Номер 19(2), С. 198 - 205

Опубликована: Янв. 27, 2016

Язык: Английский

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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Neuron, Год журнала: 2018, Номер 101(1), С. 133 - 151.e7

Опубликована: Ноя. 29, 2018

Язык: Английский

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Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

Cell, Год журнала: 2015, Номер 162(3), С. 662 - 674

Опубликована: Июль 1, 2015

Язык: Английский

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Neural Circuitry of Reward Prediction Error

Annual Review of Neuroscience, Год журнала: 2017, Номер 40(1), С. 373 - 394

Опубликована: Апрель 25, 2017

Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine make this calculation. Here we review studies that tackle problem from a diverse set approaches, anatomy to electrophysiology computational modeling behavior. Several patterns emerge synthesis: themselves calculate rather than inherit passively upstream regions; they combine multiple separate redundant inputs, which are interconnected in dense recurrent network; despite complexity output is remarkably homogeneous robust. The more study simple arithmetic computation, knottier appears be, suggesting daunting (but stimulating) path ahead for neuroscience generally.

Язык: Английский

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