The Pathobiology of Vascular Dementia

Neuron, Год журнала: 2013, Номер 80(4), С. 844 - 866

Опубликована: Ноя. 1, 2013

Язык: Английский

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Sugar for the brain: the role of glucose in physiological and pathological brain function

Trends in Neurosciences, Год журнала: 2013, Номер 36(10), С. 587 - 597

Опубликована: Авг. 20, 2013

Язык: Английский

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The theory of constructed emotion: an active inference account of interoception and categorization

Social Cognitive and Affective Neuroscience, Год журнала: 2016, Номер unknown, С. nsw154 - nsw154

Опубликована: Окт. 12, 2016

The science of emotion has been using folk psychology categories derived from philosophy to search for the brain basis emotion. last two decades neuroscience research have brought us brink a paradigm shift in understanding workings brain, however, setting stage revolutionize our what emotions are and how they work. In this article, we begin with structure function there deduce biological might be. answer is brain-based, computational account called theory constructed

Язык: Английский

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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Neuron, Год журнала: 2015, Номер 86(4), С. 883 - 901

Опубликована: Май 1, 2015

Язык: Английский

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13 reasons why the brain is susceptible to oxidative stress

Redox Biology, Год журнала: 2018, Номер 15, С. 490 - 503

Опубликована: Фев. 3, 2018

The human brain consumes 20% of the total basal oxygen (O2) budget to support ATP intensive neuronal activity. Without sufficient O2 demands, activity fails, such that, even transient ischemia is neurodegenerative. While essentiality function clear, how oxidative stress causes neurodegeneration ambiguous. Ambiguity exists because many reasons why susceptible remain obscure. Many are erroneously understood as deleterious result adventitious derived free radical and non-radical species generation. To understand underpin stress, one must first re-cast in a positive light their deliberate generation enables achieve critical functions (e.g. synaptic plasticity) through redox signalling (i.e. functionality). Using radicals derivatives signal sensitises when goes awry negative advance mechanistic understanding, we rationalise 13 stress. Key include inter alia unsaturated lipid enrichment, mitochondria, calcium, glutamate, modest antioxidant defence, active transition metals neurotransmitter auto-oxidation. We review RNA oxidation an underappreciated cause complex interplay between each reason dictates susceptibility dynamic context neural identity dependent manner. Our discourse sets stage for investigators interrogate biochemical basis health disease.

Язык: Английский

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Selective neuronal vulnerability in Parkinson disease

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(2), С. 101 - 113

Опубликована: Янв. 20, 2017

Язык: Английский

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Astrocyte calcium signaling: the third wave

Nature Neuroscience, Год журнала: 2016, Номер 19(2), С. 182 - 189

Опубликована: Янв. 27, 2016

Язык: Английский

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Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Nature Neuroscience, Год журнала: 2021, Номер 24(3), С. 425 - 436

Опубликована: Фев. 8, 2021

Язык: Английский

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Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

Cell, Год журнала: 2014, Номер 156(4), С. 825 - 835

Опубликована: Фев. 1, 2014

Cognitive function is tightly related to metabolic state, but the locus of this control not well understood. Synapses are thought present large ATP demands; however, it unclear how fuel availability and electrical activity impact synaptic levels controls function. We developed a quantitative genetically encoded optical reporter presynaptic ATP, Syn-ATP, find that imposes demands met via activity-driven both glycolysis mitochondrial discovered primary source demand vesicle cycle. In metabolically intact synapses, synthesis matched energetic needs function, which, at steady results in ∼106 free ATPs per nerve terminal. Despite reservoir we several key aspects severely impaired following even brief interruptions activity-stimulated synthesis.

Язык: Английский

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Brain Glucose Metabolism: Integration of Energetics with Function

Physiological Reviews, Год журнала: 2018, Номер 99(1), С. 949 - 1045

Опубликована: Дек. 19, 2018

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, structural components. Neuronal glucose oxidation exceeds in astrocytes, but both rates increase direct proportion to excitatory neurotransmission; signaling metabolism are closely coupled at local level. Exact details neuron-astrocyte glutamate-glutamine cycling remain be established, specific roles lactate cellular energetics these processes debated. Glycolysis preferentially upregulated during activation even though oxygen availability sufficient (aerobic glycolysis). Three major pathways, glycolysis, pentose phosphate shunt, glycogen turnover, contribute utilization excess oxygen, adrenergic regulation aerobic glycolysis draws attention astrocytic metabolism, particularly which has a high impact on oxygen-carbohydrate mismatch. Aerobic proposed predominant young children regions, re-evaluation data necessary. Shuttling glucose- glycogen-derived from astrocytes neurons activation, neurotransmission, memory consolidation controversial topics alternative mechanisms proposed. Nutritional therapy vagus nerve stimulation translational bridges clinical treatment diverse disorders.

Язык: Английский

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