The Pathobiology of Vascular Dementia

Neuron, Journal Year: 2013, Volume and Issue: 80(4), P. 844 - 866

Published: Nov. 1, 2013

Language: Английский

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Sugar for the brain: the role of glucose in physiological and pathological brain function

Trends in Neurosciences, Journal Year: 2013, Volume and Issue: 36(10), P. 587 - 597

Published: Aug. 20, 2013

Language: Английский

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The theory of constructed emotion: an active inference account of interoception and categorization

Social Cognitive and Affective Neuroscience, Journal Year: 2016, Volume and Issue: unknown, P. nsw154 - nsw154

Published: Oct. 12, 2016

The science of emotion has been using folk psychology categories derived from philosophy to search for the brain basis emotion. last two decades neuroscience research have brought us brink a paradigm shift in understanding workings brain, however, setting stage revolutionize our what emotions are and how they work. In this article, we begin with structure function there deduce biological might be. answer is brain-based, computational account called theory constructed

Language: Английский

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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Neuron, Journal Year: 2015, Volume and Issue: 86(4), P. 883 - 901

Published: May 1, 2015

Language: Английский

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13 reasons why the brain is susceptible to oxidative stress

Redox Biology, Journal Year: 2018, Volume and Issue: 15, P. 490 - 503

Published: Feb. 3, 2018

The human brain consumes 20% of the total basal oxygen (O2) budget to support ATP intensive neuronal activity. Without sufficient O2 demands, activity fails, such that, even transient ischemia is neurodegenerative. While essentiality function clear, how oxidative stress causes neurodegeneration ambiguous. Ambiguity exists because many reasons why susceptible remain obscure. Many are erroneously understood as deleterious result adventitious derived free radical and non-radical species generation. To understand underpin stress, one must first re-cast in a positive light their deliberate generation enables achieve critical functions (e.g. synaptic plasticity) through redox signalling (i.e. functionality). Using radicals derivatives signal sensitises when goes awry negative advance mechanistic understanding, we rationalise 13 stress. Key include inter alia unsaturated lipid enrichment, mitochondria, calcium, glutamate, modest antioxidant defence, active transition metals neurotransmitter auto-oxidation. We review RNA oxidation an underappreciated cause complex interplay between each reason dictates susceptibility dynamic context neural identity dependent manner. Our discourse sets stage for investigators interrogate biochemical basis health disease.

Language: Английский

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Selective neuronal vulnerability in Parkinson disease

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(2), P. 101 - 113

Published: Jan. 20, 2017

Language: Английский

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Astrocyte calcium signaling: the third wave

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(2), P. 182 - 189

Published: Jan. 27, 2016

Language: Английский

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Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(3), P. 425 - 436

Published: Feb. 8, 2021

Language: Английский

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Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

Cell, Journal Year: 2014, Volume and Issue: 156(4), P. 825 - 835

Published: Feb. 1, 2014

Cognitive function is tightly related to metabolic state, but the locus of this control not well understood. Synapses are thought present large ATP demands; however, it unclear how fuel availability and electrical activity impact synaptic levels controls function. We developed a quantitative genetically encoded optical reporter presynaptic ATP, Syn-ATP, find that imposes demands met via activity-driven both glycolysis mitochondrial discovered primary source demand vesicle cycle. In metabolically intact synapses, synthesis matched energetic needs function, which, at steady results in ∼106 free ATPs per nerve terminal. Despite reservoir we several key aspects severely impaired following even brief interruptions activity-stimulated synthesis.

Language: Английский

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Brain Glucose Metabolism: Integration of Energetics with Function

Physiological Reviews, Journal Year: 2018, Volume and Issue: 99(1), P. 949 - 1045

Published: Dec. 19, 2018

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, structural components. Neuronal glucose oxidation exceeds in astrocytes, but both rates increase direct proportion to excitatory neurotransmission; signaling metabolism are closely coupled at local level. Exact details neuron-astrocyte glutamate-glutamine cycling remain be established, specific roles lactate cellular energetics these processes debated. Glycolysis preferentially upregulated during activation even though oxygen availability sufficient (aerobic glycolysis). Three major pathways, glycolysis, pentose phosphate shunt, glycogen turnover, contribute utilization excess oxygen, adrenergic regulation aerobic glycolysis draws attention astrocytic metabolism, particularly which has a high impact on oxygen-carbohydrate mismatch. Aerobic proposed predominant young children regions, re-evaluation data necessary. Shuttling glucose- glycogen-derived from astrocytes neurons activation, neurotransmission, memory consolidation controversial topics alternative mechanisms proposed. Nutritional therapy vagus nerve stimulation translational bridges clinical treatment diverse disorders.

Language: Английский

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