Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy DOI Creative Commons
Jane Yang, Steven A. Prescott

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июнь 2, 2023

Neurons maintain their average firing rate and other properties within narrow bounds despite changing conditions. This homeostatic regulation is achieved using negative feedback to adjust ion channel expression levels. To understand how of excitability normally works it goes awry, one must consider the various channels involved as well regulated impacted by adjusting those when regulating excitability. raises issues degeneracy pleiotropy. Degeneracy refers disparate solutions conveying equivalent function (e.g., different combinations yielding excitability). many-to-one mapping contrasts one-to-many described pleiotropy affecting multiple properties). facilitates enabling a disturbance be offset compensatory changes in any several or thereof. Pleiotropy complicates because intended regulate property may inadvertently disrupt properties. Co-regulating pleiotropic requires greater than isolation and, extension, can fail for additional reasons such each being incompatible with another. Problems also arise if perturbation too strong and/or weak, set point disturbed. Delineating loops interactions provides valuable insight into might fail. Insofar failure modes require distinct interventions restore homeostasis, deeper understanding its pathological disruption reveal more effective treatments chronic neurological disorders like neuropathic pain epilepsy.

Язык: Английский

Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1 DOI Creative Commons

Vedakumar Tatavarty,

Alejandro Torrado Pacheco, Chelsea Groves Kuhnle

и другие.

Neuron, Год журнала: 2020, Номер 106(5), С. 769 - 777.e4

Опубликована: Март 20, 2020

Язык: Английский

Процитировано

112
Upward synaptic scaling is dependent on neurotransmission rather than spiking DOI Creative Commons

Ming‐fai Fong,

Jonathan P. Newman,

Steve M. Potter

и другие.

Nature Communications, Год журнала: 2015, Номер 6(1)

Опубликована: Март 9, 2015

Abstract Homeostatic plasticity encompasses a set of mechanisms that are thought to stabilize firing rates in neural circuits. The most widely studied form homeostatic is upward synaptic scaling (upscaling), characterized by multiplicative increase the strength excitatory inputs neuron as compensatory response chronic reductions rate. While reduced spiking trigger upscaling, an alternative possibility glutamatergic transmission generates this directly. However, and neurotransmission tightly coupled, so it has been difficult determine their independent roles process. Here we combined multielectrode recording, closed-loop optogenetic stimulation, pharmacology show directly triggers cell-wide upscaling. This work highlights importance activity initiating signalling cascades mediate Moreover, our findings challenge prevailing view upscaling functions homeostatically rates.

Язык: Английский

Процитировано

109
Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity DOI
Brian O. Orr, Richard D. Fetter, Graeme W. Davis

и другие.

Nature, Год журнала: 2017, Номер 550(7674), С. 109 - 113

Опубликована: Сен. 26, 2017

Язык: Английский

Процитировано

108
RIM-Binding Protein Links Synaptic Homeostasis to the Stabilization and Replenishment of High Release Probability Vesicles DOI Creative Commons
Martin Müller, Özgür Genç, Graeme W. Davis

и другие.

Neuron, Год журнала: 2015, Номер 85(5), С. 1056 - 1069

Опубликована: Фев. 19, 2015

Язык: Английский

Процитировано

99
Scribble Scaffolds a Signalosome for Active Forgetting DOI Creative Commons
Isaac Cervantes-Sandoval,

Molee Chakraborty,

Courtney MacMullen

и другие.

Neuron, Год журнала: 2016, Номер 90(6), С. 1230 - 1242

Опубликована: Июнь 1, 2016

Язык: Английский

Процитировано

99
Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation DOI Creative Commons
Ben Jiwon Choi, Wendy L. Imlach, Wei Jiao

и другие.

Neuron, Год журнала: 2014, Номер 82(3), С. 618 - 634

Опубликована: Май 1, 2014

Miniature neurotransmission is the transsynaptic process where single synaptic vesicles spontaneously released from presynaptic neurons induce miniature postsynaptic potentials. Since their discovery over 60 years ago, events have been found at every chemical synapse studied. However, in vivo necessity for these small-amplitude has remained enigmatic. Here, we show that required normal structural maturation of Drosophila glutamatergic synapses a developmental role not shared by evoked neurotransmission. Conversely, find increasing sufficient to terminal growth. We acts locally terminals regulate via Trio guanine nucleotide exchange factor (GEF) and Rac1 GTPase molecular signaling pathway. Our results establish neurotransmission, universal but often-overlooked feature synapses, unique essential functions vivo.

Язык: Английский

Процитировано

96
Homeostatic role of heterosynaptic plasticity: models and experiments DOI Creative Commons

Marina Chistiakova,

Nicholas M. Bannon,

Jen‐Yung Chen

и другие.

Frontiers in Computational Neuroscience, Год журнала: 2015, Номер 9

Опубликована: Июль 13, 2015

Homosynaptic Hebbian-type plasticity provides a cellular mechanism of learning and refinement connectivity during development in variety biological systems. In this review we argue that complimentary form - heterosynaptic represents necessary component for homeostatic regulation synaptic weights neuronal activity. The required properties which acutely constrains the runaway dynamics imposed by Hebbian associative have been well-articulated theoretical modeling studies. Such mechanism(s) should robustly support stability operation networks competition, include changes at non-active synapses, operate on similar time scale to plasticity. experimentally observed introduced it as strong candidate fulfill role. Subsequent studies incorporate into model neurons with synapses (utilizing an STDP rule) confirmed its ability provide competition. contrast, scaling, is triggered extreme long lasting (hours days) activity, do not fit two crucial requirements hypothetical needed face on-going driven rules. Both trigger scaling are fundamentally different from those We conclude plasticity, same episodes postsynaptic activity operates ideally suited serve role

Язык: Английский

Процитировано

94
Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release DOI Creative Commons
Varun Gupta, Ulrike Pech, Anuradha Bhukel

и другие.

PLoS Biology, Год журнала: 2016, Номер 14(9), С. e1002563 - e1002563

Опубликована: Сен. 29, 2016

Memories are assumed to be formed by sets of synapses changing their structural or functional performance. The efficacy forming new memories declines with advancing age, but the synaptic changes underlying age-induced memory impairment remain poorly understood. Recently, we found spermidine feeding specifically suppress age-dependent impairments in olfactory memories, providing a mean search for involved impairment. Here, show that specific compartment, presynaptic active zone (AZ), increases size its ultrastructural elaboration and releases significantly more vesicles age. These AZ changes, however, were fully suppressed feeding. A genetically enforced enlargement scaffolds (four gene-copies BRP) impaired formation young animals. Thus, Drosophila nervous system, aging AZs seem steer towards upper limit operational range, limiting plasticity contributing formation. Spermidine suppresses counteracting these directly at synapse.

Язык: Английский

Процитировано

93
Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish DOI Creative Commons
Robert A. Kozol, Alexander J. Abrams,

David M. James

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2016, Номер 9

Опубликована: Июль 6, 2016

Zebrafish are a unique cell to behavior model for studying the basic biology of human inherited neurological conditions. Conserved vertebrate genetics and optical transparency provide in vivo access developing nervous system as well high-throughput approaches drug screens. Here we review zebrafish modeling two broad groups conditions that each share genetic molecular pathways overlap phenotypically: cognitive neurodevelopmental disorders such Autism Spectrum Disorders, Intellectual Disability Schizophrenia, neurodegenerative diseases, Cerebellar Ataxia, Hereditary Spastic Paraplegia Charcot-Marie Tooth disease. We also conduct small meta-analysis orthologues high confidence disorder disease genes by looking at duplication rates relative protein sizes. In past models these diseases have provided insight into cellular, circuit behavioral level mechanisms contributing Moving forward, advances manipulation, live imaging neuronal activity automated screening promise help delineate mechanistic relationships between different types accelerate discovery therapeutic strategies.

Язык: Английский

Процитировано

91
Linking alpha oscillations, attention and inhibitory control in adult ADHD with EEG neurofeedback DOI Creative Commons
Marie‐Pierre Deiber, Roland Hasler, Julien Colin

и другие.

NeuroImage Clinical, Год журнала: 2019, Номер 25, С. 102145 - 102145

Опубликована: Дек. 24, 2019

Abnormal patterns of electrical oscillatory activity have been repeatedly described in adult ADHD. In particular, the alpha rhythm (8-12 Hz), known to be modulated during attention, has previously considered as candidate biomarker for present study, we asked ADHD patients self-regulate their own using neurofeedback (NFB), order examine modulation oscillations on attentional performance and brain plasticity. Twenty-five 22 healthy controls underwent a 64-channel EEG-recording at resting-state Go/NoGo task, before after 30 min-NFB session designed reduce (desynchronize) power rhythm. Alpha was compared across conditions groups, effects NFB were statistically assessed by comparing behavioral EEG measures pre-to-post NFB. Firstly, found that relative attenuated our cohort control subjects baseline experimental conditions, suggesting signature cortical hyper-activation. Both groups demonstrated significant targeted reduction Interestingly, observed post-NFB increase (i.e. rebound) group, which restored towards levels normal population. Importantly, degree normalization task correlated with individual improvements motor inhibition reduced commission errors) only group. Overall, findings offer novel supporting evidence implicating inhibitory control, well potential role homeostatic regulation excitatory/inhibitory balance.

Язык: Английский

Процитировано

91