Mechanisms
regulating
the
turnover
of
synaptic
vesicle
(SV)
proteins
are
not
well
understood.
They
thought
to
require
poly-ubiquitination
and
degradation
through
proteasome,
endo-lysosomal
or
autophagy-related
pathways.
Bassoon
was
shown
negatively
regulate
presynaptic
autophagy
in
part
by
scaffolding
Atg5.
Here,
we
show
that
increased
knockout
neurons
depends
on
loss
leads
elevated
levels
ubiquitinated
per
se.
Our
data
have
a
smaller
SV
pool
size
higher
rate
as
indicated
younger
SV2.
The
E3
ligase
Parkin
is
required
for
Bassoon-deficient
knockdown
normalized
protein
rescued
impaired
recycling.
These
indicate
key
regulator
proteostasis
autophagy-mediated
clearance
proteins.
Having
your
longevity
and
eating
too
Although
caloric
restriction
has
clear
benefits
for
maximizing
health
span
life
span,
it
is
sufficiently
unpleasant
that
few
humans
stick
to
it.
Madeo
et
al.
review
evidence
increased
intake
of
the
polyamine
spermidine
appears
reproduce
many
healthful
effects
restriction,
they
explain
its
cellular
actions,
which
include
enhancement
autophagy
protein
deacetylation.
Spermidine
found
in
foods
such
as
wheat
germ,
soybeans,
nuts,
some
fruits
vegetables
produced
by
microbiota.
Increased
uptake
protective
against
cancer,
metabolic
disease,
heart
neurodegeneration.
Science
,
this
issue
p.
eaan2788
Annual Review of Biochemistry,
Год журнала:
2023,
Номер
92(1), С. 435 - 464
Опубликована: Апрель 5, 2023
The
polyamines
putrescine,
spermidine,
and
spermine
are
abundant
polycations
of
vital
importance
in
mammalian
cells.
Their
cellular
levels
tightly
regulated
by
degradation
synthesis,
as
well
uptake
export.
Here,
we
discuss
the
delicate
balance
between
neuroprotective
neurotoxic
effects
context
Parkinson's
disease
(PD).
Polyamine
decline
with
aging
altered
patients
PD,
whereas
recent
mechanistic
studies
on
ATP13A2
(PARK9)
demonstrated
a
driving
role
disturbed
polyamine
homeostasis
PD.
Polyamines
affect
pathways
PD
pathogenesis,
such
α-synuclein
aggregation,
influence
PD-related
processes
like
autophagy,
heavy
metal
toxicity,
oxidative
stress,
neuroinflammation,
lysosomal/mitochondrial
dysfunction.
We
formulate
outstanding
research
questions
regarding
their
potential
biomarkers,
possible
therapeutic
strategies
for
targeting
homeostasis.
Cells,
Год журнала:
2024,
Номер
13(1), С. 103 - 103
Опубликована: Янв. 4, 2024
Autophagy
is
a
major
degradative
pathway
that
plays
key
role
in
sustaining
cell
homeostasis,
integrity,
and
physiological
functions.
Macroautophagy,
which
ensures
the
clearance
of
cytoplasmic
components
engulfed
double-membrane
autophagosome
fuses
with
lysosomes,
orchestrated
by
complex
cascade
events.
has
particularly
strong
impact
on
nervous
system,
mutations
core
cause
numerous
neurological
diseases.
We
first
review
regulation
autophagy,
from
biogenesis
to
lysosomal
degradation
associated
neurodevelopmental/neurodegenerative
disorders.
then
describe
how
this
process
specifically
regulated
axon
somatodendritic
compartment
it
altered
In
particular,
we
present
neuronal
specificities
spatial
control
biogenesis,
close
relationship
maturation
axonal
transport,
synaptic
activity.
Finally,
discuss
functions
autophagy
during
development
adulthood.
The Journal of Cell Biology,
Год журнала:
2017,
Номер
216(7), С. 1895 - 1906
Опубликована: Май 17, 2017
Synapses
are
functionally
distinct
neuronal
compartments
that
critical
for
brain
function,
with
synaptic
dysfunction
being
an
early
pathological
feature
in
aging
and
disease.
Given
the
large
number
of
proteins
needed
proliferation
defective
subsequent
loss
protein
homeostasis
may
be
a
leading
cause
dysfunction.
Autophagic
mechanisms
cellular
digestion
processes
recycle
components
contribute
to
homeostasis.
Autophagy
is
important
within
nervous
system,
but
its
function
specific
such
as
synapse
has
been
unclear.
Evidence
from
research
on
both
autophagy
suggests
there
links
between
two
during
requires
regulate
Exciting
new
work
autophagy-modulating
enriched
at
begun
link
synapses
A
better
understanding
these
will
help
us
harness
potential
therapeutic
benefits
combating
age-related
disorders
system.
