Cell and Tissue Research,
Год журнала:
2021,
Номер
383(1), С. 207 - 225
Опубликована: Янв. 1, 2021
Abstract
Behavioral
flexibility
for
appropriate
action
selection
is
an
advantage
when
animals
are
faced
with
decisions
that
will
determine
their
survival
or
death.
In
order
to
arrive
at
the
right
decision,
evaluate
information
from
external
environment,
internal
state,
and
past
experiences.
How
these
different
signals
integrated
modulated
in
brain,
how
context-
state-dependent
behavioral
controlled
poorly
understood
questions.
Studying
molecules
help
convey
integrate
such
neural
circuits
important
way
approach
Many
years
of
work
model
organisms
have
shown
dopamine
a
critical
neuromodulator
(reward
based)
associative
learning.
However,
recent
findings
vertebrates
invertebrates
demonstrated
complexity
heterogeneity
dopaminergic
neuron
populations
functional
implications
many
adaptive
behaviors
survival.
For
example,
neurons
can
sensory
information,
states,
learned
experience
decision
making
circuitry.
Several
advances
methodologies
availability
synaptic
level
connectome
whole-brain
circuitry
Drosophila
melanogaster
make
fly
attractive
system
study
roles
behavior.
particular,
learning
memory
center—the
mushroom
body—is
richly
innervated
by
enable
it
multi-modal
according
state
context,
modulate
decision-making
Annual Review of Neuroscience,
Год журнала:
2017,
Номер
40(1), С. 327 - 348
Опубликована: Апрель 25, 2017
Animals
are
born
with
a
rich
repertoire
of
robust
behaviors
that
critical
for
their
survival.
However,
innate
also
highly
adaptable
to
an
animal's
internal
state
and
external
environment.
Neuromodulators,
including
biogenic
amines,
neuropeptides,
hormones,
released
signal
changes
in
animals'
circumstances
serve
reconfigure
neural
circuits.
This
circuit
flexibility
allows
animals
modify
behavioral
responses
according
environmental
cues,
metabolic
demands,
physiological
states.
Aided
by
powerful
genetic
tools,
researchers
have
made
remarkable
progress
Drosophila
melanogaster
address
how
myriad
contextual
information
influences
the
input-output
relationship
hardwired
circuits
support
complex
repertoire.
Here
we
highlight
recent
advances
understanding
neuromodulation
behaviors,
special
focus
on
feeding,
courtship,
aggression,
postmating
behaviors.
Nature Communications,
Год журнала:
2017,
Номер
8(1)
Опубликована: Июль 21, 2017
Animals
execute
one
particular
behavior
among
many
others
in
a
context-dependent
manner,
yet
the
mechanisms
underlying
such
behavioral
choice
remain
poorly
understood.
Here
we
studied
how
two
fundamental
behaviors,
sex
and
sleep,
interact
at
genetic
neuronal
levels
Drosophila.
We
show
that
an
increased
need
for
sleep
inhibits
male
sexual
by
decreasing
activity
of
male-specific
P1
neurons
coexpress
determination
genes
fru
M
dsx,
but
does
not
affect
female
behavior.
Further,
delineate
sex-specific
circuit
wherein
encoding
courtship
drive
suppressed
forming
mutually
excitatory
connections
with
-positive
sleep-controlling
DN1
neurons.
In
addition,
find
FRUM
regulates
through
distinct
neural
substrates.
These
studies
reveal
basis
interaction
between
behaviors
Drosophila,
provide
insights
into
competing
are
co-regulated.Genes
circuits
involved
arousal
have
been
extensively
authors
identify
fruitless
doublesex,
P1-DN1
feedback
governs
these
behaviors.
