Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Янв. 22, 2021
Abstract
Optogenetics
is
a
powerful
technique
that
allows
target-specific
spatiotemporal
manipulation
of
neuronal
activity
for
dissection
neural
circuits
and
therapeutic
interventions.
Recent
advances
in
wireless
optogenetics
technologies
have
enabled
investigation
brain
more
natural
conditions
by
releasing
animals
from
tethered
optical
fibers.
However,
current
implants,
which
are
largely
based
on
battery-powered
or
battery-free
designs,
still
limit
the
full
potential
vivo
freely
moving
requiring
intermittent
battery
replacement
special,
bulky
power
transfer
system
continuous
device
operation,
respectively.
To
address
these
limitations,
here
we
present
wirelessly
rechargeable,
fully
implantable,
soft
optoelectronic
can
be
remotely
selectively
controlled
using
smartphone.
Combining
advantageous
features
both
this
enables
seamless
implantation
into
animals,
reliable
ubiquitous
intervention-free
charging,
all
desired
chronic
optogenetics.
Successful
demonstration
unique
capabilities
behaving
rats
forecasts
its
broad
practical
utilities
various
neuroscience
research
clinical
applications.
Materials,
Год журнала:
2018,
Номер
11(2), С. 187 - 187
Опубликована: Янв. 24, 2018
Flexible
hybrid
electronics
(FHE),
designed
in
wearable
and
implantable
configurations,
have
enormous
applications
advanced
healthcare,
rapid
disease
diagnostics,
persistent
human-machine
interfaces.
Soft,
contoured
geometries
time-dynamic
deformation
of
the
targeted
tissues
require
high
flexibility
stretchability
integrated
bioelectronics.
Recent
progress
developing
engineering
soft
materials
has
provided
a
unique
opportunity
to
design
various
types
mechanically
compliant
deformable
systems.
Here,
we
summarize
required
properties
their
characteristics
for
configuring
sensing
substrate
components
devices
Details
functionality
sensitivity
recently
developed
FHE
are
discussed
with
application
areas
medicine,
machine
interactions.
This
review
concludes
discussion
on
limitations
current
materials,
key
requirements
next
generation
new
areas.
Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Дек. 17, 2019
Small
animals
support
a
wide
range
of
pathological
phenotypes
and
genotypes
as
versatile,
affordable
models
for
pathogenesis
cardiovascular
diseases
exploration
strategies
in
electrotherapy,
gene
therapy,
optogenetics.
Pacing
tools
such
contexts
are
currently
limited
to
tethered
embodiments
that
constrain
animal
behaviors
experimental
designs.
Here,
we
introduce
highly
miniaturized
wireless
energy-harvesting
digital
communication
electronics
thin,
pacing
platforms
weighing
110
mg
with
capabilities
subdermal
implantation
tolerance
over
200,000
multiaxial
cycles
strain
without
degradation
electrical
or
optical
performance.
Multimodal
multisite
ex
vivo
studies
many
days
demonstrate
chronic
stability
excellent
biocompatibility.
Optogenetic
stimulation
cardiac
in-animal
control
induction
heart
failure
through
serve
examples
modes
operation
relevant
fundamental
applied
research
biomedical
technology.
Advanced Materials,
Год журнала:
2018,
Номер
30(30)
Опубликована: Май 31, 2018
Abstract
Technologies
capable
of
establishing
intimate,
long‐lived
optical/electrical
interfaces
to
neural
systems
will
play
critical
roles
in
neuroscience
research
and
the
development
nonpharmacological
treatments
for
neurological
disorders.
The
high‐density
3D
populations
neurons
across
entire
tissue
living
animals,
including
human
subjects,
represents
a
grand
challenge
field,
where
advanced
biocompatible
materials
engineered
structures
electrodes
light
emitters
be
essential.
This
review
summarizes
recent
progress
these
directions,
with
an
emphasis
on
most
promising
demonstrated
concepts,
materials,
devices,
systems.
article
begins
overview
electrode
enhanced
electrical
and/or
mechanical
performance,
forms
ranging
from
planar
films,
micro/nanostructured
surfaces,
porous
frameworks
soft
composites.
Subsequent
sections
highlight
integration
active
components
multiplexed
addressing,
local
amplification,
wireless
data
transmission,
power
harvesting,
multimodal
operation
soft,
shape‐conformal
These
advances
establish
foundations
scalable
architectures
future,
blurring
lines
between
biotic
abiotic
catalyze
profound
health/well‐being.
Laser & Photonics Review,
Год журнала:
2021,
Номер
15(5)
Опубликована: Март 24, 2021
Abstract
Typical
light‐emitting
diodes
(LEDs)
have
a
form
factor
>(300
×
300)
µm
2
.
Such
LEDs
are
commercially
mature
in
illumination
and
ultralarge
displays.
However,
recent
LED
research
includes
shrinking
individual
sizes
from
side
lengths
>300
to
values
<100
µm,
leading
devices
called
micro‐LEDs.
Their
advent
creates
number
of
exciting
new
application
spaces.
Here,
review
the
principles
applications
micro‐LED
technology
is
presented.
In
particular,
implications
reduced
size
necessitating
mitigation
strategies
for
nonradiative
device
edge
damage
as
well
potential
higher
drive
current
densities
discussed.
The
opportunities
integrate
micro‐LEDs
with
electronics,
into
large‐scale
arrays,
allow
pixel
addressable
scalable
integrated
displays,
while
small
ideal
high‐speed
modulation
visible
light
communication,
integration
biological
systems
part
optogenetic
therapies.
Studies
of
the
peripheral
nervous
system
rely
on
controlled
manipulation
neuronal
function
with
pharmacologic
and/or
optogenetic
techniques.
Traditional
hardware
for
these
purposes
can
cause
notable
damage
to
fragile
nerve
tissues,
create
irritation
at
biotic/abiotic
interface,
and
alter
natural
behaviors
animals.
Here,
we
present
a
wireless,
battery-free
device
that
integrates
microscale
inorganic
light-emitting
diode
an
ultralow-power
microfluidic
electrochemical
pumping
mechanism
in
soft
platform
be
mounted
onto
target
nerves
programmed
delivery
light
pharmacological
agents
freely
moving
Biocompliant
designs
lead
minimal
effects
overall
health
function,
even
chronic
use
vivo.
The
small
size
weight
construction
allow
deployment
as
fully
implantable
devices
mice.
These
features
opportunities
studies
outside
scope
those
possible
existing
technologies.
