Materials Today Bio,
Journal Year:
2021,
Volume and Issue:
12, P. 100149 - 100149
Published: Sept. 1, 2021
Magnetoelectric
(ME)
effect
experimentally
discovered
about
60
years
ago
remains
one
of
the
promising
research
fields
with
main
applications
in
microelectronics
and
sensors.
However,
its
to
biology
medicine
are
still
their
infancy.
For
diagnosis
treatment
diseases
at
intracellular
level,
it
is
necessary
develop
a
maximally
non-invasive
way
local
stimulation
individual
neurons,
navigation,
distribution
biomolecules
damaged
cells
relatively
high
efficiency
adequate
spatial
temporal
resolution.
Recently
developed
ME
materials
(composites),
which
combine
elastically
coupled
piezoelectric
(PE)
magnetostrictive
(MS)
phases,
have
been
shown
yield
very
strong
effects
even
room
temperature.
This
makes
them
toolbox
for
solving
many
problems
modern
medicine.
The
materials,
processing
technologies,
as
well
most
prospective
biomedical
will
be
overviewed,
trends
using
future
therapies,
wireless
power
transfer,
optogenetics
considered.
Materials,
Journal Year:
2018,
Volume and Issue:
11(2), P. 187 - 187
Published: Jan. 24, 2018
Flexible
hybrid
electronics
(FHE),
designed
in
wearable
and
implantable
configurations,
have
enormous
applications
advanced
healthcare,
rapid
disease
diagnostics,
persistent
human-machine
interfaces.
Soft,
contoured
geometries
time-dynamic
deformation
of
the
targeted
tissues
require
high
flexibility
stretchability
integrated
bioelectronics.
Recent
progress
developing
engineering
soft
materials
has
provided
a
unique
opportunity
to
design
various
types
mechanically
compliant
deformable
systems.
Here,
we
summarize
required
properties
their
characteristics
for
configuring
sensing
substrate
components
devices
Details
functionality
sensitivity
recently
developed
FHE
are
discussed
with
application
areas
medicine,
machine
interactions.
This
review
concludes
discussion
on
limitations
current
materials,
key
requirements
next
generation
new
areas.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Dec. 17, 2019
Small
animals
support
a
wide
range
of
pathological
phenotypes
and
genotypes
as
versatile,
affordable
models
for
pathogenesis
cardiovascular
diseases
exploration
strategies
in
electrotherapy,
gene
therapy,
optogenetics.
Pacing
tools
such
contexts
are
currently
limited
to
tethered
embodiments
that
constrain
animal
behaviors
experimental
designs.
Here,
we
introduce
highly
miniaturized
wireless
energy-harvesting
digital
communication
electronics
thin,
pacing
platforms
weighing
110
mg
with
capabilities
subdermal
implantation
tolerance
over
200,000
multiaxial
cycles
strain
without
degradation
electrical
or
optical
performance.
Multimodal
multisite
ex
vivo
studies
many
days
demonstrate
chronic
stability
excellent
biocompatibility.
Optogenetic
stimulation
cardiac
in-animal
control
induction
heart
failure
through
serve
examples
modes
operation
relevant
fundamental
applied
research
biomedical
technology.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(30)
Published: May 31, 2018
Abstract
Technologies
capable
of
establishing
intimate,
long‐lived
optical/electrical
interfaces
to
neural
systems
will
play
critical
roles
in
neuroscience
research
and
the
development
nonpharmacological
treatments
for
neurological
disorders.
The
high‐density
3D
populations
neurons
across
entire
tissue
living
animals,
including
human
subjects,
represents
a
grand
challenge
field,
where
advanced
biocompatible
materials
engineered
structures
electrodes
light
emitters
be
essential.
This
review
summarizes
recent
progress
these
directions,
with
an
emphasis
on
most
promising
demonstrated
concepts,
materials,
devices,
systems.
article
begins
overview
electrode
enhanced
electrical
and/or
mechanical
performance,
forms
ranging
from
planar
films,
micro/nanostructured
surfaces,
porous
frameworks
soft
composites.
Subsequent
sections
highlight
integration
active
components
multiplexed
addressing,
local
amplification,
wireless
data
transmission,
power
harvesting,
multimodal
operation
soft,
shape‐conformal
These
advances
establish
foundations
scalable
architectures
future,
blurring
lines
between
biotic
abiotic
catalyze
profound
health/well‐being.
Abstract
Typical
light‐emitting
diodes
(LEDs)
have
a
form
factor
>(300
×
300)
µm
2
.
Such
LEDs
are
commercially
mature
in
illumination
and
ultralarge
displays.
However,
recent
LED
research
includes
shrinking
individual
sizes
from
side
lengths
>300
to
values
<100
µm,
leading
devices
called
micro‐LEDs.
Their
advent
creates
number
of
exciting
new
application
spaces.
Here,
review
the
principles
applications
micro‐LED
technology
is
presented.
In
particular,
implications
reduced
size
necessitating
mitigation
strategies
for
nonradiative
device
edge
damage
as
well
potential
higher
drive
current
densities
discussed.
The
opportunities
integrate
micro‐LEDs
with
electronics,
into
large‐scale
arrays,
allow
pixel
addressable
scalable
integrated
displays,
while
small
ideal
high‐speed
modulation
visible
light
communication,
integration
biological
systems
part
optogenetic
therapies.
Science Advances,
Journal Year:
2019,
Volume and Issue:
5(7)
Published: July 5, 2019
Studies
of
the
peripheral
nervous
system
rely
on
controlled
manipulation
neuronal
function
with
pharmacologic
and/or
optogenetic
techniques.
Traditional
hardware
for
these
purposes
can
cause
notable
damage
to
fragile
nerve
tissues,
create
irritation
at
biotic/abiotic
interface,
and
alter
natural
behaviors
animals.
Here,
we
present
a
wireless,
battery-free
device
that
integrates
microscale
inorganic
light-emitting
diode
an
ultralow-power
microfluidic
electrochemical
pumping
mechanism
in
soft
platform
be
mounted
onto
target
nerves
programmed
delivery
light
pharmacological
agents
freely
moving
Biocompliant
designs
lead
minimal
effects
overall
health
function,
even
chronic
use
vivo.
The
small
size
weight
construction
allow
deployment
as
fully
implantable
devices
mice.
These
features
opportunities
studies
outside
scope
those
possible
existing
technologies.
