Synaptic motility and functional stability in the whisker cortex DOI Creative Commons
Nimrod Sherf, Maoz Shamir

Physical Review Research, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 29, 2025

The high motility of synaptic weights raises the question how brain can retain its functionality in face constant remodeling. Here we used whisker system rats and mice to study interplay between plasticity (motility) transmission sensory signals downstream. Rats probe their surroundings by rhythmically moving whiskers back forth. azimuthal position a be estimated from activity whisking neurons that respond selectively preferred phase along cycle. These phases are widely distributed on ring. However, simple models for signal downstream predict distribution is an order magnitude narrower than empirically observed. Here, suggest form spike-timing-dependent (STDP) may provide solution this conundrum. This hypothesis addressed framework modeling investigated STDP dynamics population synapses propagates findings showed that, wide range parameters, do not relax fixed point. As result, drift time at nonuniform velocity, which turn induces population. demonstrates functionality, terms phases, retained simply despite, but because motility. Our analysis leads several key empirical predictions test hypothesis. Published American Physical Society 2025

Язык: Английский

The mechanosensory neurons of touch and their mechanisms of activation DOI
Annie Handler, David D. Ginty

Nature reviews. Neuroscience, Год журнала: 2021, Номер 22(9), С. 521 - 537

Опубликована: Июль 26, 2021

Язык: Английский

Процитировано

273
Sensorimotor processing in the rodent barrel cortex DOI
Carl C.H. Petersen

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(9), С. 533 - 546

Опубликована: Июль 31, 2019

Язык: Английский

Процитировано

237
Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior DOI Creative Commons
Jianing Yu, Hang Hu, Ariel Agmon

и другие.

Neuron, Год журнала: 2019, Номер 104(2), С. 412 - 427.e4

Опубликована: Авг. 26, 2019

Язык: Английский

Процитировано

193
Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity DOI Creative Commons
Leah J. Elias,

Isabella K. Succi,

Melanie D. Schaffler

и другие.

Cell, Год журнала: 2023, Номер 186(3), С. 577 - 590.e16

Опубликована: Янв. 23, 2023

Pleasurable touch is paramount during social behavior, including sexual encounters. However, the identity and precise role of sensory neurons that transduce remain unknown. A population labeled by developmental expression G protein-coupled receptor Mrgprb4 detects mechanical stimulation in mice. Here, we study relevance Mrgprb4-lineage reveal these are required for receptivity sufficient to induce dopamine release brain. Even isolation, optogenetic through back skin a conditioned place preference striking dorsiflexion resembling lordotic copulatory posture. In absence neurons, female mice no longer find male mounts rewarding: supplanted aggression coincident decline nucleus accumbens. Together, findings establish initiate skin-to-brain circuit encoding rewarding quality touch.

Язык: Английский

Процитировано

62
Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications DOI Creative Commons
Yilin Sun,

Huaipeng Wang,

Dan Xie

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июнь 6, 2024

Abstract Manipulating the expression of synaptic plasticity neuromorphic devices provides fascinating opportunities to develop hardware platforms for artificial intelligence. However, great efforts have been devoted exploring biomimetic mechanisms simulation in last few years. Recent progress various modulation techniques has pushed research electronics from static dynamic modulation, improving accuracy computing and providing strategies implementing sensing functions. Herein, several through chemical techniques, device structure design, physical signal are reviewed. For underlying modification functional materials were clarified its effect on was also highlighted. Based reconfigurable operation well demonstrated achieve programmable Besides, integrating sensory units with processing circuits paved a new way human-like intelligent perception under signals such as light, strain, temperature. Finally, considering that relevant technology is still basic exploration stage, some prospects or development suggestions put forward promote devices.

Язык: Английский

Процитировано

21
Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics DOI Creative Commons
Thomas Vaissière,

Sheldon D. Michaelson,

Thomas K. Creson

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 18, 2025

Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice expression of the autism/intellectual disability gene, Syngap1, cortical excitatory neurons is formation somatomotor networks promote SMI-mediated perception. Cortical Syngap1 was necessary and sufficient setting tactile sensitivity, sustaining object exploration, promoting learning. Mice with deficient exhibited impaired neural dynamics induced by exploratory touches within cortical-thalamic network promotes attention Disrupted neuronal were associated circuit-specific long-range synaptic connectivity abnormalities. Our data support model where autonomous abilities assembly circuits integrate temporally-overlapping sensory motor signals, process attention. These provide systems-level insights into robust association between ability.

Язык: Английский

Процитировано

2
Neuronal Circuits in Barrel Cortex for Whisker Sensory Perception DOI
Jochen F. Staiger, Carl C.H. Petersen

Physiological Reviews, Год журнала: 2020, Номер 101(1), С. 353 - 415

Опубликована: Авг. 20, 2020

The array of whiskers on the snout provides rodents with tactile sensory information relating to size, shape and texture objects in their immediate environment. Rodents can use detect stimuli, distinguish textures, locate navigate. Important aspects whisker sensation are thought result from neuronal computations somatosensory cortex (wS1). Each is individually represented somatotopic map wS1 by an anatomical unit named a ‘barrel’ (hence also called barrel cortex). This allows precise investigation processing context well-defined map. Here, we first review signaling pathways wS1, then discuss current understanding various types excitatory inhibitory neurons present within wS1. Different classes cells be defined according anatomical, electrophysiological molecular features. synaptic connectivity local microcircuits, as well long-range interactions impact neuromodulators, beginning understood. Recent technological progress has allowed cell-type-specific related activity during whisker-related behaviors. An important goal for future research obtain causal mechanistic how selected processed specific synaptically connected networks signaled downstream brain areas, thus contributing sensory-guided decision-making.

Язык: Английский

Процитировано

113
Circuits in the Rodent Brainstem that Control Whisking in Concert with Other Orofacial Motor Actions DOI Creative Commons
Lauren E. McElvain, Beth Friedman,

Harvey J. Karten

и другие.

Neuroscience, Год журнала: 2017, Номер 368, С. 152 - 170

Опубликована: Авг. 23, 2017

Язык: Английский

Процитировано

89
A Flexible Artificial Sensory Nerve Enabled by Nanoparticle‐Assembled Synaptic Devices for Neuromorphic Tactile Recognition DOI Creative Commons
Chengpeng Jiang, Jiaqi Liu, Lu Yang

и другие.

Advanced Science, Год журнала: 2022, Номер 9(24)

Опубликована: Июнь 9, 2022

Tactile perception enabled by somatosensory system in human is essential for dexterous tool usage, communication, and interaction. Imparting tactile recognition functions to advanced robots interactive systems can potentially improve their cognition intelligence. Here, a flexible artificial sensory nerve that mimics the sensing, neural coding, synaptic processing developed achieve neuromorphic at device level without relying on algorithms or computing resources. An interfacial self-assembly technique, which produces uniform defect-less thin film of semiconductor nanoparticles arbitrary substrates, employed prepare device. The facilitation memory characteristics proton-gating enable this identify material hardness during robotic grasping recognize tapping patterns interaction continuous, real-time, high-accuracy manner, demonstrating intelligence capabilities. This produced wearable portable form be readily integrated with smart human-machine interfaces implementing human-like electronics toward applications.

Язык: Английский

Процитировано

52
Neuromorphic Hardware for Artificial Sensory Systems: A Review DOI Creative Commons
Youngmin Kim,

Chung Won Lee,

Ho Won Jang

и другие.

Journal of Electronic Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Abstract Senses are crucial for an organism’s survival, and there have been numerous efforts to artificially replicate sensory perception elicit desired responses specific stimuli. Recent research is increasingly focused on developing artificial nervous systems based the unsupervised learning capabilities of neural networks (ANNs) using unstructured data. However, future ANNs, which require precise sensing in complex environments, must be capable processing a large number signals real time, ideally from continuous domains. This need massive data driving evolution hardware systems, leading development devices specifically designed (ASSs) at level. To address this challenge, sensor not only detect target substances but also enable computational functions by utilizing their inherent material properties. Research neuromorphic sensors advancing towards integration with next-generation effectively addressing scenarios we aim identify. review offers perspectives human-like computing these challenges. It examines progress implementing five representative senses device level, explores methods integrating them into ASS, provides comprehensive overview potential applications. In particular, emphasize approaches cognitively utilize discussed as neurons synapses, enabling inputs. We offer nerve future.

Язык: Английский

Процитировано

1