Negative feedback control of neuronal activity by microglia

Nature, Год журнала: 2020, Номер 586(7829), С. 417 - 423

Опубликована: Сен. 30, 2020

Язык: Английский

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Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

eLife, Год журнала: 2018, Номер 7

Опубликована: Фев. 22, 2018

In vivo calcium imaging through microendoscopic lenses enables of previously inaccessible neuronal populations deep within the brains freely moving animals. However, it is computationally challenging to extract single-neuronal activity from data, because very large background fluctuations and high spatial overlaps intrinsic this recording modality. Here, we describe a new constrained matrix factorization approach accurately separate then demix denoise signals interest. We compared proposed method against previous independent components analysis nonnegative approaches. On both simulated experimental data recorded mice, our substantially improved quality extracted cellular detected more well-isolated neural signals, especially in noisy regimes. These advances can turn significantly enhance statistical power downstream analyses, ultimately improve scientific conclusions derived data.

Язык: Английский

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Dopamine neuron activity before action initiation gates and invigorates future movements

Nature, Год журнала: 2018, Номер 554(7691), С. 244 - 248

Опубликована: Янв. 31, 2018

Язык: Английский

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Striatal circuits for reward learning and decision-making

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(8), С. 482 - 494

Опубликована: Июнь 6, 2019

Язык: Английский

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Circuit Mechanisms of Parkinson’s Disease

Neuron, Год журнала: 2019, Номер 101(6), С. 1042 - 1056

Опубликована: Март 1, 2019

Язык: Английский

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The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection

Cell, Год журнала: 2018, Номер 174(1), С. 44 - 58.e17

Опубликована: Май 17, 2018

Язык: Английский

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Computational Neuroethology: A Call to Action

Neuron, Год журнала: 2019, Номер 104(1), С. 11 - 24

Опубликована: Окт. 1, 2019

Язык: Английский

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Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

Nature, Год журнала: 2018, Номер 557(7704), С. 177 - 182

Опубликована: Апрель 30, 2018

Язык: Английский

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Quantifying behavior to understand the brain

Nature Neuroscience, Год журнала: 2020, Номер 23(12), С. 1537 - 1549

Опубликована: Ноя. 9, 2020

Язык: Английский

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Revealing the structure of pharmacobehavioral space through motion sequencing

Nature Neuroscience, Год журнала: 2020, Номер 23(11), С. 1433 - 1443

Опубликована: Сен. 21, 2020

Язык: Английский

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