Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning DOI Creative Commons
Scott F. Owen, Joshua D. Berke, Anatol C. Kreitzer

et al.

Cell, Journal Year: 2018, Volume and Issue: 172(4), P. 683 - 695.e15

Published: Feb. 1, 2018

Language: Английский

Negative feedback control of neuronal activity by microglia DOI
Ana Badimon, Hayley J. Strasburger, Pinar Ayata

et al.

Nature, Journal Year: 2020, Volume and Issue: 586(7829), P. 417 - 423

Published: Sept. 30, 2020

Language: Английский

Citations

738
Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data DOI Creative Commons
Pengcheng Zhou, Shanna L. Resendez, Jose Rodríguez-Romaguera

et al.

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Feb. 22, 2018

In vivo calcium imaging through microendoscopic lenses enables of previously inaccessible neuronal populations deep within the brains freely moving animals. However, it is computationally challenging to extract single-neuronal activity from data, because very large background fluctuations and high spatial overlaps intrinsic this recording modality. Here, we describe a new constrained matrix factorization approach accurately separate then demix denoise signals interest. We compared proposed method against previous independent components analysis nonnegative approaches. On both simulated experimental data recorded mice, our substantially improved quality extracted cellular detected more well-isolated neural signals, especially in noisy regimes. These advances can turn significantly enhance statistical power downstream analyses, ultimately improve scientific conclusions derived data.

Language: Английский

Citations

693
Dopamine neuron activity before action initiation gates and invigorates future movements DOI
Joaquim Alves da Silva, Fatuel Tecuapetla, Vítor Paixão

et al.

Nature, Journal Year: 2018, Volume and Issue: 554(7691), P. 244 - 248

Published: Jan. 31, 2018

Language: Английский

Citations

554
Striatal circuits for reward learning and decision-making DOI
Julia Cox, Ilana B. Witten

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(8), P. 482 - 494

Published: June 6, 2019

Language: Английский

Citations

484
Circuit Mechanisms of Parkinson’s Disease DOI Creative Commons
Matthew McGregor, Alexandra Nelson

Neuron, Journal Year: 2019, Volume and Issue: 101(6), P. 1042 - 1056

Published: March 1, 2019

Language: Английский

Citations

445
The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection DOI Creative Commons
Jeffrey E. Markowitz, Winthrop F. Gillis, Celia Beron

et al.

Cell, Journal Year: 2018, Volume and Issue: 174(1), P. 44 - 58.e17

Published: May 17, 2018

Language: Английский

Citations

404
Computational Neuroethology: A Call to Action DOI Creative Commons
Sandeep Robert Datta, David J. Anderson, Kristin Branson

et al.

Neuron, Journal Year: 2019, Volume and Issue: 104(1), P. 11 - 24

Published: Oct. 1, 2019

Language: Английский

Citations

392
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states DOI
Jones G. Parker, Jesse D. Marshall, Biafra Ahanonu

et al.

Nature, Journal Year: 2018, Volume and Issue: 557(7704), P. 177 - 182

Published: April 30, 2018

Language: Английский

Citations

328
Quantifying behavior to understand the brain DOI
Talmo Pereira, Joshua W. Shaevitz, Mala Murthy

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(12), P. 1537 - 1549

Published: Nov. 9, 2020

Language: Английский

Citations

258
Revealing the structure of pharmacobehavioral space through motion sequencing DOI
Alexander B. Wiltschko, Tatsuya Tsukahara,

Ayman Zeine

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(11), P. 1433 - 1443

Published: Sept. 21, 2020

Language: Английский

Citations

251