Journal of Neural Engineering,
Год журнала:
2019,
Номер
17(1), С. 016036 - 016036
Опубликована: Ноя. 15, 2019
Objective.-Microfabricatedmultielectrode
arrays
are
widely
used
for
high
throughput
recording
of
extracellular
neural
activity,
which
is
transforming
our
understanding
brain
function
in
health
and
disease.Currently
there
a
plethora
electrode-based
tools
being
developed
at
higher
education
research
institutions.However,
taking
such
from
the
initial
development
phase
to
widespread
adoption
by
neuroscience
community
often
hindered
several
obstacles.The
objective
this
work
describe
development,
application,
open
dissemination
silicon
microprobes
activity
vivo.Approach.-Wepropose
an
source
platform
as
alternative
commercialization.This
framework
promotes
that
openly
inexpensively
available
community.The
designed
house,
but
fabrication
assembly
processes
carried
out
third
party
companies.This
enables
mass
production,
key
requirement
large-scale
dissemination.Main
results.-Wedemonstrate
operation
containing
up
256
electrodes
conjunction
with
optical
fibers
optogenetic
manipulations
or
fiber
photometry.These
data
provide
new
insights
about
relationship
between
calcium
spiking
activity.We
also
current
state
these
tools.A
file
repository
resources
related
designing,
using,
sharing
maintained
online.Significance.-Thispaper
likely
be
valuable
resource
both
prospective
users,
well
developers
microprobes.Based
on
their
extensive
usage
number
labs
including
ours,
present
promising
other
types
technologies
aimed
head-fixed
animals.This
demonstrates
importance
validating
photometry
measurements
simultaneous
electrophysiological
recordings.
Journal of Medical Internet Research,
Год журнала:
2019,
Номер
21(10), С. e16194 - e16194
Опубликована: Окт. 14, 2019
Brain-machine
interfaces
hold
promise
for
the
restoration
of
sensory
and
motor
function
treatment
neurological
disorders,
but
clinical
brain-machine
have
not
yet
been
widely
adopted,
in
part,
because
modest
channel
counts
limited
their
potential.
In
this
white
paper,
we
describe
Neuralink's
first
steps
toward
a
scalable
high-bandwidth
interface
system.
We
built
arrays
small
flexible
electrode
"threads,"
with
as
many
3072
electrodes
per
array
distributed
across
96
threads.
also
neurosurgical
robot
capable
inserting
six
threads
(192
electrodes)
minute.
Each
thread
can
be
individually
inserted
into
brain
micron
precision
avoidance
surface
vasculature
targeting
specific
regions.
The
is
packaged
implantable
device
that
contains
custom
chips
low-power
on-board
amplification
digitization:
package
channels
occupies
less
than
23×18.5×2
mm
Measuring
the
dynamics
of
neural
processing
across
time
scales
requires
following
spiking
thousands
individual
neurons
over
milliseconds
and
months.
To
address
this
need,
we
introduce
Neuropixels
2.0
probe
together
with
newly
designed
analysis
algorithms.
The
has
more
than
5000
sites
is
miniaturized
to
facilitate
chronic
implants
in
small
mammals
recording
during
unrestrained
behavior.
High-quality
recordings
long
were
reliably
obtained
mice
rats
six
laboratories.
Improved
site
density
arrangement
combined
created
data
methods
enable
automatic
post
hoc
correction
for
brain
movements,
allowing
from
same
2
These
probes
algorithms
stable
free
behavior,
even
animals
such
as
mice.
Frontiers in Neurorobotics,
Год журнала:
2020,
Номер
14
Опубликована: Июнь 3, 2020
Brain-Computer
Interface
(BCI),
in
essence,
aims
at
controlling
different
assistive
devices
through
the
utilization
of
brain
waves.
It
is
worth
noting
that
application
BCI
not
limited
to
medical
applications,
and
hence,
research
this
field
has
gained
due
attention.
Moreover,
significant
number
related
publications
over
past
two
decades
further
indicates
consistent
improvements
breakthroughs
have
been
made
particular
field.
Nonetheless,
it
also
mentioning
with
these
improvements,
new
challenges
are
constantly
discovered.
This
article
provides
a
comprehensive
review
state-of-the-art
complete
system.
First,
brief
overview
electroencephalogram
(EEG)-based
systems
given.
Secondly,
considerable
popular
applications
reviewed
terms
electrophysiological
control
signals,
feature
extraction,
classification
algorithms,
performance
evaluation
metrics.
Finally,
recent
discussed,
possible
solutions
mitigate
issues
recommended.
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(11)
Опубликована: Май 10, 2021
To
understand
the
physiology
and
pathology
of
electrogenic
cells
corresponding
tissue
in
their
full
complexity,
quantitative
investigation
transmission
ions
as
well
release
chemical
signals
is
important.
Organic
(semi-)
conducting
materials
particular
organic
electrochemical
transistor
are
gaining
importance
for
electrophysiological
recently
biochemical
due
to
synthetic
nature
thus
diversity
modifiability,
biocompatible
compliant
properties,
mixed
electronic
ionic
conductivity
featuring
ion-to-electron
conversion.
Here,
aim
summarize
recent
progress
on
development
bioelectronic
devices
utilizing
polymer
polyethylenedioxythiophene:
poly(styrene
sulfonate)
(PEDOT:PSS)
interface
electronics
biological
matter
including
microelectrode
arrays,
neural
cuff
electrodes,
transistors,
PEDOT:PSS-based
biosensors,
ion
pumps.
Finally,
material
summarized
improvement
conductivity,
stretchability,
higher
transconductance,
or
extend
field
application
such
cation
sensing
metabolite
recognition.
This
survey
trends
PEDOT:PSS
sensors
highlights
potential
this
multifunctional
revolve
current
technology
enable
long-lasting,
multichannel
probes
simultaneous
recordings
from
cells.
