eNeuro,
Год журнала:
2022,
Номер
9(3), С. ENEURO.0068 - 22.2022
Опубликована: Апрель 18, 2022
Abstract
Understanding
the
long-term
effects
of
stress
on
brain
function
is
crucial
for
understanding
mechanisms
depression.
The
BALB/c
mouse
strain
has
high
susceptibility
to
and
thus
an
effective
model
repeated
social
defeat
(SDS)
mice,
however,
are
not
clear.
Here,
we
investigated
SDS
in
male
mice
over
subsequent
two
weeks.
Some
defeated
immediately
exhibited
avoidance,
whereas
anxiety-like
behavior
was
only
evident
at
later
periods.
Furthermore,
segregated
into
groups
based
level
namely,
avoidant
nonavoidant
mice.
characteristic
avoidance
or
nonavoidance
each
individual
fixed
In
addition,
developed
a
semi-automated
method
analyzing
c-Fos
expression
investigate
effect
activity
more
than
weeks
after
end
exposure.
Following
interaction,
reduced
several
regions
compared
with
control
correlation
among
these
areas,
exception
medial
prefrontal
cortex
(mPFC)
central
amygdala
(CeA),
increased
suggesting
synchrony.
Notably,
lateral
habenula
(LHb)
different
between
that
from
those
These
observations
provide
insight
activity.
Proceedings of the National Academy of Sciences,
Год журнала:
2021,
Номер
118(7)
Опубликована: Фев. 9, 2021
Significance
The
basal
forebrain
(BF)
is
traditionally
recognized
as
a
brain
structure
crucial
for
arousal,
attention,
learning,
and
memory.
Here,
we
discovered
causal
role
of
the
BF
in
control
prosocial
behavior,
which
fundamental
our
daily
life.
We
showed
mice
that
somatostatin-expressing
inhibitory
neurons
predominantly
target
GABA
disinhibit
dopamine
ventral
tegmental
area
thereby
increase
release
nucleus
accumbens.
This
disinhibitory
circuitry
played
an
essential
promoting
social
interaction
behavior.
Our
findings
identify
previously
unknown
function
behavior
regulation
suggest
potential
therapeutic
deficits
commonly
observed
major
neuropsychiatric
disorders.
eNeuro,
Год журнала:
2022,
Номер
9(3), С. ENEURO.0068 - 22.2022
Опубликована: Апрель 18, 2022
Abstract
Understanding
the
long-term
effects
of
stress
on
brain
function
is
crucial
for
understanding
mechanisms
depression.
The
BALB/c
mouse
strain
has
high
susceptibility
to
and
thus
an
effective
model
repeated
social
defeat
(SDS)
mice,
however,
are
not
clear.
Here,
we
investigated
SDS
in
male
mice
over
subsequent
two
weeks.
Some
defeated
immediately
exhibited
avoidance,
whereas
anxiety-like
behavior
was
only
evident
at
later
periods.
Furthermore,
segregated
into
groups
based
level
namely,
avoidant
nonavoidant
mice.
characteristic
avoidance
or
nonavoidance
each
individual
fixed
In
addition,
developed
a
semi-automated
method
analyzing
c-Fos
expression
investigate
effect
activity
more
than
weeks
after
end
exposure.
Following
interaction,
reduced
several
regions
compared
with
control
correlation
among
these
areas,
exception
medial
prefrontal
cortex
(mPFC)
central
amygdala
(CeA),
increased
suggesting
synchrony.
Notably,
lateral
habenula
(LHb)
different
between
that
from
those
These
observations
provide
insight
activity.
