Long-Term Effects of Repeated Social Defeat Stress on Brain Activity during Social Interaction in BALB/c Mice DOI Creative Commons

Hibiki Okamura,

Shinnosuke Yasugaki,

Haruka Suzuki-Abe

et al.

eNeuro, Journal Year: 2022, Volume and Issue: 9(3), P. ENEURO.0068 - 22.2022

Published: April 18, 2022

Abstract Understanding the long-term effects of stress on brain function is crucial for understanding mechanisms depression. The BALB/c mouse strain has high susceptibility to and thus an effective model repeated social defeat (SDS) mice, however, are not clear. Here, we investigated SDS in male mice over subsequent two weeks. Some defeated immediately exhibited avoidance, whereas anxiety-like behavior was only evident at later periods. Furthermore, segregated into groups based level namely, avoidant nonavoidant mice. characteristic avoidance or nonavoidance each individual fixed In addition, developed a semi-automated method analyzing c-Fos expression investigate effect activity more than weeks after end exposure. Following interaction, reduced several regions compared with control correlation among these areas, exception medial prefrontal cortex (mPFC) central amygdala (CeA), increased suggesting synchrony. Notably, lateral habenula (LHb) different between that from those These observations provide insight activity.

Language: Английский

The Raphe Dopamine System: Roles in Salience Encoding, Memory Expression, and Addiction DOI
Rui Lin,

Jingwen Liang,

Minmin Luo

et al.

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(5), P. 366 - 377

Published: Feb. 8, 2021

Language: Английский

Citations

30
Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons DOI Open Access
Jun Wang, Jie Li, Qian Yang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(7)

Published: Feb. 9, 2021

Significance The basal forebrain (BF) is traditionally recognized as a brain structure crucial for arousal, attention, learning, and memory. Here, we discovered causal role of the BF in control prosocial behavior, which fundamental our daily life. We showed mice that somatostatin-expressing inhibitory neurons predominantly target GABA disinhibit dopamine ventral tegmental area thereby increase release nucleus accumbens. This disinhibitory circuitry played an essential promoting social interaction behavior. Our findings identify previously unknown function behavior regulation suggest potential therapeutic deficits commonly observed major neuropsychiatric disorders.

Language: Английский

Citations

28
A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code DOI Creative Commons
Zhengwei Yuan,

Zhongyang Qi,

Ruiyu Wang

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(23), P. 3837 - 3853.e5

Published: Sept. 20, 2023

Language: Английский

Citations

12
The dorsal raphe nucleus in the control of energy balance DOI
Varun Bhave, Alexander R. Nectow

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(12), P. 946 - 960

Published: Oct. 18, 2021

Language: Английский

Citations

24
Long-Term Effects of Repeated Social Defeat Stress on Brain Activity during Social Interaction in BALB/c Mice DOI Creative Commons

Hibiki Okamura,

Shinnosuke Yasugaki,

Haruka Suzuki-Abe

et al.

eNeuro, Journal Year: 2022, Volume and Issue: 9(3), P. ENEURO.0068 - 22.2022

Published: April 18, 2022

Abstract Understanding the long-term effects of stress on brain function is crucial for understanding mechanisms depression. The BALB/c mouse strain has high susceptibility to and thus an effective model repeated social defeat (SDS) mice, however, are not clear. Here, we investigated SDS in male mice over subsequent two weeks. Some defeated immediately exhibited avoidance, whereas anxiety-like behavior was only evident at later periods. Furthermore, segregated into groups based level namely, avoidant nonavoidant mice. characteristic avoidance or nonavoidance each individual fixed In addition, developed a semi-automated method analyzing c-Fos expression investigate effect activity more than weeks after end exposure. Following interaction, reduced several regions compared with control correlation among these areas, exception medial prefrontal cortex (mPFC) central amygdala (CeA), increased suggesting synchrony. Notably, lateral habenula (LHb) different between that from those These observations provide insight activity.

Language: Английский

Citations

19