Learning enhances behaviorally relevant representations in apical dendrites DOI Creative Commons
Sam E. Benezra, Kripa Patel, Citlali Pérez Campos

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Июнь 13, 2024

Learning alters cortical representations and improves perception. Apical tuft dendrites in layer 1, which are unique their connectivity biophysical properties, may be a key site of learning-induced plasticity. We used both two-photon SCAPE microscopy to longitudinally track tuft-wide calcium spikes apical 5 pyramidal neurons barrel cortex as mice learned tactile behavior. Mice were trained discriminate two orthogonal directions whisker stimulation. Reinforcement learning, but not repeated stimulus exposure, enhanced selectivity for equally, even though only one was associated with reward. Selective tufts emerged from initially unresponsive or low-selectivity populations. Animal movement choice did account changes selectivity. Enhanced persisted after rewards removed animals ceased performing the task. conclude that learning produces long-lasting realignment dendrite responses behaviorally relevant dimensions

Язык: Английский

A transcriptomic axis predicts state modulation of cortical interneurons DOI Creative Commons
Stéphane Bugeon, Joshua Duffield, Mario Dipoppa

и другие.

Nature, Год журнала: 2022, Номер 607(7918), С. 330 - 338

Опубликована: Июль 6, 2022

Abstract Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine molecular subtypes 1–6 , but it is not known whether these have correspondingly diverse patterns activity in the living brain. Here we show primary visual cortex (V1) correlates with brain state, which are organized by single factor: position along main axis transcriptomic variation. We combined vivo two-photon calcium imaging mouse V1 method to identify mRNA for 72 selected genes ex slices. classified imaged layers 1–3 into three-level hierarchy 5 subclasses, 11 types and 35 using previously defined clusters 3 . Responses stimuli differed significantly only between cells Sncg subclass uniformly suppressed, other subclasses predominantly excited. Modulation state at all hierarchical levels could be largely predicted from first principal component, also correlations simultaneously recorded cells. Inhibitory fired more resting, oscillatory states had smaller fraction their axonal projections layer 1, narrower spikes, lower input resistance weaker adaptation as determined vitro 7 expressed cholinergic receptors. Subtypes during arousal opposite properties. Thus, simple principle may explain how shape state-dependent processing.

Язык: Английский

Процитировано

125
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity DOI
Sweyta Lohani,

Andrew H. Moberly,

Hadas Benisty

и другие.

Nature Neuroscience, Год журнала: 2022, Номер 25(12), С. 1706 - 1713

Опубликована: Ноя. 28, 2022

Язык: Английский

Процитировано

109
Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning DOI Creative Commons
Chi Ren, Kailong Peng,

Ruize Yang

и другие.

Neuron, Год журнала: 2022, Номер 110(14), С. 2334 - 2350.e8

Опубликована: Май 17, 2022

Язык: Английский

Процитировано

62
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment DOI Creative Commons
Zoltán Szadai,

Hyun-Jae Pi,

Quentin Chevy

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Ноя. 23, 2022

Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward punishment are represented cortical computations. Previously, we identified a neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, auditory cortex that recruited by behavioral reinforcers mediates disinhibitory control inhibiting other inhibitory neurons. As the same circuit present virtually throughout cortex, wondered whether VIP neurons likewise cortex. We monitored neural activity dozens of regions using three-dimensional random access two-photon microscopy fiber photometry while mice learned an discrimination task. found during initial learning produce rapid, cortex-wide activation most interneurons. This recruitment mode showed variations temporal dynamics individual across areas. Neither weak sensory tuning interneurons visual nor their arousal state modulation was fully predictive reinforcer responses. suggest response supports cell-type-specific mechanism which organism-level information about regulates processing plasticity.

Язык: Английский

Процитировано

41
Neocortical somatostatin neuron diversity in cognition and learning DOI Creative Commons
Eunsol Park, Matthew B. Mosso, Alison L. Barth

и другие.

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Cortical sensory processing across motivational states during goal-directed behavior DOI Creative Commons
Giulio Matteucci, Maëlle Guyoton,

Johannes M. Mayrhofer

и другие.

Neuron, Год журнала: 2022, Номер 110(24), С. 4176 - 4193.e10

Опубликована: Окт. 13, 2022

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these relate to task and learning. We trained water-restricted mice a two-whisker discrimination study cortical circuits underlying perceptual decision-making under different levels thirst. identified somatosensory cortices as well the premotor cortex part circuit necessary for execution. Two-photon calcium imaging areas populations selective or motor events. Analysis during individual sessions revealed distinct behavioral induced by decreasing thirst-related motivation. Learning was better explained improvements motivational state control rather than association. Whisker were across states. In particular, whisker stimuli could be decoded from activity high states, suggesting that state-dependent changes processing decision-making.

Язык: Английский

Процитировано

32
VIP interneurons regulate cortical size tuning and visual perception DOI Creative Commons
Katie Ferguson,

Jenna Salameh,

Christopher Alba

и другие.

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113088 - 113088

Опубликована: Сен. 1, 2023

Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping operation according to behavioral context. A specialized population co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs pyramidal neurons (PNs). Although state-dependent modulation VIP-INs has been studied, their role regulating sensory processing less well understood. We examined the impact primary visual cortex awake behaving mice. Loss VIP-IN activity alters somatostatin-expressing (SST-INs) but not PNs. In contrast, reduced globally disrupts feature selectivity for stimulus size. Moreover, on perceptual behavior varies with context more acute small than large cues. thus contribute both cortical context-dependent performance.

Язык: Английский

Процитировано

19
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

и другие.

Neuron, Год журнала: 2023, Номер 112(2), С. 184 - 200

Опубликована: Окт. 31, 2023

Язык: Английский

Процитировано

18
Brain-wide presynaptic networks of functionally distinct cortical neurons DOI Creative Commons
Ana R. Inácio, Ka Chun Lam, Yuan Zhao

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Revealing the connectivity of functionally identified individual neurons is necessary to understand how activity patterns emerge and support behaviour. Yet brain-wide presynaptic wiring rules that lay foundation for functional selectivity remain largely unexplored. Cortical neurons, even in primary sensory cortex, are heterogeneous their selectivity, not only stimuli but also multiple aspects Here, investigate underlying pyramidal behavioural state 1–10 somatosensory cortex (S1), we used two-photon calcium imaging, neuropharmacology, single-cell-based monosynaptic input tracing optogenetics. We show state-dependent stable over time. These minimally affected by direct neuromodulatory inputs driven primarily glutamatergic inputs. Analysis networks with distinct profiles revealed although state-related state-unrelated shared a similar pattern local within S1, long-range differed. Individual cortical irrespective properties, received converging from main S1-projecting areas. tracked smaller proportion motor larger thalamic Optogenetic suppression reduced this was externally driven. Our results reveal as substrate preconfigured network dynamics associated state.

Язык: Английский

Процитировано

1
Adaptive control of synaptic plasticity integrates micro- and macroscopic network function DOI Creative Commons
Daniel N. Scott, Michael J. Frank

Neuropsychopharmacology, Год журнала: 2022, Номер 48(1), С. 121 - 144

Опубликована: Авг. 29, 2022

Synaptic plasticity configures interactions between neurons and is therefore likely to be a primary driver of behavioral learning development. How this microscopic-macroscopic interaction occurs poorly understood, as researchers frequently examine models within particular ranges abstraction scale. Computational neuroscience machine offer theoretically powerful analyses in neural networks, but results are often siloed only coarsely linked biology. In review, we connections these areas, asking how network computations change function diverse features vice versa. We review can controlled at synapses by calcium dynamics neuromodulatory signals, the manifestation changes their impacts specialized circuits. conclude that metaplasticity-defined broadly adaptive control plasticity-forges across scales governing what groups can't learn about, when, ends. The metaplasticity discuss acts co-opting Hebbian mechanisms, shifting properties, routing activity brain systems. Asking operations go awry should also useful for understanding pathology, which address context autism, schizophrenia Parkinson's disease.

Язык: Английский

Процитировано

26