Wide-field imaging in behaving mice as a tool to study cognitive function DOI Creative Commons
Ariel Gilad

Neurophotonics, Год журнала: 2024, Номер 11(03)

Опубликована: Фев. 19, 2024

Cognitive functions are mediated through coordinated and dynamic neuronal responses that involve many different areas across the brain. Therefore, it is of high interest to simultaneously record activity from as brain possible while subject performs a cognitive behavioral task. One emerging tools achieve mesoscopic field view wide-field imaging cortex-wide dynamics in mice. Wide-field cost-effective, user-friendly, enables obtaining signals mice performing complex demanding tasks. Importantly, offers an unbiased observation sheds light on overlooked cortical regions highlights parallel processing circuits. Recent studies have shown multi-area patterns, rather than just single area, involved encoding functions. The optical properties enable signals, such layer-specific, inhibitory subtypes, or neuromodulation signals. Here, I review main advantages mice, recent literature, discuss future directions field. It expected behaving will continue gain popularity aid understanding mesoscale underlying function.

Язык: Английский

Why is everyone talking about brain state? DOI Creative Commons
Abigail S. Greene, Corey Horien, Daniel Barson

и другие.

Trends in Neurosciences, Год журнала: 2023, Номер 46(7), С. 508 - 524

Опубликована: Май 8, 2023

The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.

Язык: Английский

Процитировано

86
Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement DOI Creative Commons
Spencer Bowles, Jordan Hickman,

Xiaoyu Peng

и другие.

Neuron, Год журнала: 2022, Номер 110(17), С. 2867 - 2885.e7

Опубликована: Июль 19, 2022

Язык: Английский

Процитировано

84
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment DOI Creative Commons
Zoltán Szadai,

Hyun-Jae Pi,

Quentin Chevy

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Ноя. 23, 2022

Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward punishment are represented cortical computations. Previously, we identified a neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, auditory cortex that recruited by behavioral reinforcers mediates disinhibitory control inhibiting other inhibitory neurons. As the same circuit present virtually throughout cortex, wondered whether VIP neurons likewise cortex. We monitored neural activity dozens of regions using three-dimensional random access two-photon microscopy fiber photometry while mice learned an discrimination task. found during initial learning produce rapid, cortex-wide activation most interneurons. This recruitment mode showed variations temporal dynamics individual across areas. Neither weak sensory tuning interneurons visual nor their arousal state modulation was fully predictive reinforcer responses. suggest response supports cell-type-specific mechanism which organism-level information about regulates processing plasticity.

Язык: Английский

Процитировано

41
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Creative Commons

Shohei Furutachi,

Alexis D. Franklin, Andreea M. Aldea

и другие.

Nature, Год журнала: 2024, Номер 633(8029), С. 398 - 406

Опубликована: Авг. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

Процитировано

17
Neocortical somatostatin neuron diversity in cognition and learning DOI Creative Commons
Eunsol Park, Matthew B. Mosso, Alison L. Barth

и другие.

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning DOI
William J. Wright, Nathan G. Hedrick, Takaki Komiyama

и другие.

Science, Год журнала: 2025, Номер 388(6744), С. 322 - 328

Опубликована: Апрель 17, 2025

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of in vivo during whether these are uniform within individual neurons remain unclear. Using longitudinal imaging with single-synapse resolution mouse motor cortex learning, we found that apical basal dendrites layer 2/3 (L2/3) pyramidal showed distinct activity-dependent rules. The strengthening is predicted local coactivity nearby coincident postsynaptic action potentials, respectively. Blocking spiking diminished potentiation without affecting plasticity. Thus, use multiple a compartment-specific manner learning.

Язык: Английский

Процитировано

1
VIP interneurons regulate cortical size tuning and visual perception DOI Creative Commons
Katie Ferguson,

Jenna Salameh,

Christopher Alba

и другие.

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113088 - 113088

Опубликована: Сен. 1, 2023

Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping operation according to behavioral context. A specialized population co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs pyramidal neurons (PNs). Although state-dependent modulation VIP-INs has been studied, their role regulating sensory processing less well understood. We examined the impact primary visual cortex awake behaving mice. Loss VIP-IN activity alters somatostatin-expressing (SST-INs) but not PNs. In contrast, reduced globally disrupts feature selectivity for stimulus size. Moreover, on perceptual behavior varies with context more acute small than large cues. thus contribute both cortical context-dependent performance.

Язык: Английский

Процитировано

18
Cortico-basal ganglia plasticity in motor learning DOI Creative Commons
Richard H. Roth, Jun Ding

Neuron, Год журнала: 2024, Номер 112(15), С. 2486 - 2502

Опубликована: Июль 12, 2024

Язык: Английский

Процитировано

9
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

и другие.

Neuron, Год журнала: 2023, Номер 112(2), С. 184 - 200

Опубликована: Окт. 31, 2023

Язык: Английский

Процитировано

16
VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals DOI Creative Commons
Deepa L. Ramamurthy, A. Chen, Jiayu Zhou

и другие.

Current Biology, Год журнала: 2023, Номер 33(16), С. 3398 - 3408.e7

Опубликована: Июль 26, 2023

Vasoactive intestinal peptide (VIP) interneurons in sensory cortex modulate responses based on global exploratory behavior and arousal state, but their function during non-exploratory, goal-directed is not well understood. In particular, whether VIP cells are activated by cues, reward-seeking actions, or directly reinforcement unclear. We trained mice a Go/NoGo whisker touch detection task that included delay period other features designed to separate sensory-evoked, action-related, reward-related neural activity. Mice had lick response stimulus receive variable-sized reward. Using two-photon calcium imaging, we measured ΔF/F of L2/3 neurons somatosensory (S1) behavior. both expert novice mice, were strongly stimuli actions (licking), reinforcement. showed somatotopic tuning was spatially organized relative anatomical columns S1, unlike lick-related signals which widespread. suppressed, enhanced, when reward delivered, the amount suppression increased with size. This seen where delivery yoked licking. These results indicate besides state variables, local Instead, our consistent role for encoding expectation associated motor actions.

Язык: Английский

Процитировано

14