The spike-timing-dependent plasticity of VIP interneurons in motor cortex DOI Creative Commons

Amanda R. McFarlan,

Connie Guo,

Isabella Gomez

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Апрель 19, 2024

The plasticity of inhibitory interneurons (INs) plays an important role in the organization and maintenance cortical microcircuits. Given many different IN types, there is even greater diversity synapse-type-specific learning rules at excitatory to (E→I), I→E, I→I synapses. synapses play a key disinhibitory circuits. Because they typically target other INs, vasoactive intestinal peptide (VIP) INs are often featured I→I→E disinhibition, which upregulates activity nearby neurons. VIP dysregulation may thus lead neuropathologies such as epilepsy. In spite regulatory their long-term has not been described. Therefore, we characterized phenomenology spike-timing-dependent (STDP) inputs outputs genetically defined INs. Using combination whole-cell recording, 2-photon microscopy, optogenetics, explored STDP layer 2/3 (L2/3) onto L5 Martinotti cells (MCs) basket (BCs). We found that IN→MC underwent causal depression (LTD) was presynaptically expressed. IN→BC connections, however, did undergo any detectable plasticity. Conversely, using extracellular stimulation, E→I revealed potentiation (LTP) for both acausal timings. Taken together, our results demonstrate possess outputs. This suggests possibility harnessing control activity-related

Язык: Английский

Why is everyone talking about brain state? DOI Creative Commons
Abigail S. Greene, Corey Horien, Daniel Barson

и другие.

Trends in Neurosciences, Год журнала: 2023, Номер 46(7), С. 508 - 524

Опубликована: Май 8, 2023

The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.

Язык: Английский

Процитировано

84
Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement DOI Creative Commons
Spencer Bowles, Jordan Hickman,

Xiaoyu Peng

и другие.

Neuron, Год журнала: 2022, Номер 110(17), С. 2867 - 2885.e7

Опубликована: Июль 19, 2022

Язык: Английский

Процитировано

81
Neocortical somatostatin neuron diversity in cognition and learning DOI Creative Commons
Eunsol Park, Matthew B. Mosso, Alison L. Barth

и другие.

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment DOI Creative Commons
Zoltán Szadai,

Hyun-Jae Pi,

Quentin Chevy

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Ноя. 23, 2022

Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward punishment are represented cortical computations. Previously, we identified a neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, auditory cortex that recruited by behavioral reinforcers mediates disinhibitory control inhibiting other inhibitory neurons. As the same circuit present virtually throughout cortex, wondered whether VIP neurons likewise cortex. We monitored neural activity dozens of regions using three-dimensional random access two-photon microscopy fiber photometry while mice learned an discrimination task. found during initial learning produce rapid, cortex-wide activation most interneurons. This recruitment mode showed variations temporal dynamics individual across areas. Neither weak sensory tuning interneurons visual nor their arousal state modulation was fully predictive reinforcer responses. suggest response supports cell-type-specific mechanism which organism-level information about regulates processing plasticity.

Язык: Английский

Процитировано

41
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Creative Commons

Shohei Furutachi,

Alexis D. Franklin, Andreea M. Aldea

и другие.

Nature, Год журнала: 2024, Номер 633(8029), С. 398 - 406

Опубликована: Авг. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

Процитировано

17
Cortico-basal ganglia plasticity in motor learning DOI Creative Commons
Richard H. Roth, Jun Ding

Neuron, Год журнала: 2024, Номер 112(15), С. 2486 - 2502

Опубликована: Июль 12, 2024

Язык: Английский

Процитировано

9
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning DOI
William J. Wright, Nathan G. Hedrick, Takaki Komiyama

и другие.

Science, Год журнала: 2025, Номер 388(6744), С. 322 - 328

Опубликована: Апрель 17, 2025

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of in vivo during whether these are uniform within individual neurons remain unclear. Using longitudinal imaging with single-synapse resolution mouse motor cortex learning, we found that apical basal dendrites layer 2/3 (L2/3) pyramidal showed distinct activity-dependent rules. The strengthening is predicted local coactivity nearby coincident postsynaptic action potentials, respectively. Blocking spiking diminished potentiation without affecting plasticity. Thus, use multiple a compartment-specific manner learning.

Язык: Английский

Процитировано

1
VIP interneurons regulate cortical size tuning and visual perception DOI Creative Commons
Katie Ferguson,

Jenna Salameh,

Christopher Alba

и другие.

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113088 - 113088

Опубликована: Сен. 1, 2023

Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping operation according to behavioral context. A specialized population co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs pyramidal neurons (PNs). Although state-dependent modulation VIP-INs has been studied, their role regulating sensory processing less well understood. We examined the impact primary visual cortex awake behaving mice. Loss VIP-IN activity alters somatostatin-expressing (SST-INs) but not PNs. In contrast, reduced globally disrupts feature selectivity for stimulus size. Moreover, on perceptual behavior varies with context more acute small than large cues. thus contribute both cortical context-dependent performance.

Язык: Английский

Процитировано

17
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

и другие.

Neuron, Год журнала: 2023, Номер 112(2), С. 184 - 200

Опубликована: Окт. 31, 2023

Язык: Английский

Процитировано

15
Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness DOI Creative Commons
Baba Yogesh, Georg B. Keller

eLife, Год журнала: 2023, Номер 12

Опубликована: Сен. 25, 2023

Acetylcholine is released in visual cortex by axonal projections from the basal forebrain. The signals conveyed these and their computational significance are still unclear. Using two-photon calcium imaging behaving mice, we show that forebrain cholinergic axons mouse provide a binary locomotion state signal. In axons, found no evidence of responses to stimuli or visuomotor prediction errors. While optogenetic activation isolation did not drive local neuronal activity, when paired with stimuli, it resulted layer-specific increases activity. Responses layer 5 neurons both top-down bottom-up inputs were increased amplitude decreased latency, whereas those 2/3 remained unchanged. opto- chemogenetic manipulations acetylcholine underlie locomotion-associated decorrelation activity between 5. Our results suggest augments responsiveness outside network, possibly enabling faster switching internal representations during locomotion.

Язык: Английский

Процитировано

14