Episodic memory development: Bridging animal and human research

Neuron, Год журнала: 2024, Номер 112(7), С. 1060 - 1080

Опубликована: Фев. 14, 2024

Human episodic memory is not functionally evident until about 2 years of age and continues to develop into the school years. Behavioral studies have elucidated this developmental timeline its constituent processes. In tandem, lesion neurophysiological in non-human primates rodents identified key neural substrates circuit mechanisms that may underlie development. Despite progress, collaborative efforts between psychologists neuroscientists remain limited, hindering progress. Here, we seek bridge human development research by offering a comparative review using humans, primates, rodents. We highlight critical theoretical methodological issues limit cross-fertilization propose common framework, adaptable different species, facilitate cross-species endeavors.

Язык: Английский

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Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

eLife, Год журнала: 2022, Номер 11

Опубликована: Дек. 28, 2022

In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning behavior via transient changes neuronal activity during development. Whether comparable exist for non-sensory cortices, such as the prefrontal cortex, alterations determine circuit function is still an active area of research. Here, using mice we demonstrate that inhibition parvalbumin (PV)-expressing interneurons juvenile adolescent period, results persistent impairments connectivity, vivo network function, behavioral flexibility be reversed by targeted activation PV adulthood. contrast, reversible suppression interneuron adulthood produces no effects. These findings identify activity-dependent period maturation highlight how abnormal development alters cognitive behavior.

Язык: Английский

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Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity

Frontiers in Molecular Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Янв. 3, 2022

Throughout early phases of brain development, the two main neural signaling mechanisms-excitation and inhibition-are dynamically sculpted in neocortex to establish primary functions. Despite its relatively late formation persistent developmental changes, GABAergic system promotes ordered shaping neuronal circuits at structural functional levels. Within this frame, interneurons participate first spontaneous later sensory-evoked activity patterns that precede cortical functions mature brain. Upon their subcortical generation, embryonic must orderly migrate settle respective target layers before they can actively engage network activity. During process, changes molecular synaptic level allow not only coordinated but also pruning connections as well excitatory inhibitory synapses. At postsynaptic site, shift from an towards response is required enable synchronization within networks. Concomitantly, progressive specification different interneuron subtypes endows with distinct local region-specific modulation firing. Finally, apoptotic process further refines populations by constantly maintaining a controlled ratio neurons. Interestingly, many these fundamental complex processes are influenced-if directly controlled-by electrical Interneurons on subcellular, cellular, affected high frequency patterns, such spindle burst gamma oscillations rodents delta brushes humans. Conversely, maturation structure function each scales feeds back contributes generation essential for proper peri- postnatal development. Overall, more precise description conducting role terms how contribute specific patterns-as impinge orchestra members-will lead better understanding physiological pathophysiological development nervous system.

Язык: Английский

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Adolescent sleep and the foundations of prefrontal cortical development and dysfunction

Progress in Neurobiology, Год журнала: 2022, Номер 218, С. 102338 - 102338

Опубликована: Авг. 10, 2022

Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence, when disruption by delayed chronotypes and societal pressures coincides with our brains preparing for adult via intense refinement of neural connectivity. These vulnerabilities converge on prefrontal cortex, one last regions mature a central hub limbic-cortical circuits underpinning decision-making, reward processing, social interactions emotion. Even subtle cortical development adolescence therefore have enduring impact. In this review, we integrate synaptic circuit mechanisms, glial biology, neurophysiology epidemiology, frame hypothesis highlighting implications adolescent circuitry cortex. Convergent evidence underscores importance acknowledging, quantifying optimizing sleep's contributions normative lifelong mental health.

Язык: Английский

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Thalamocortical Development: A Neurodevelopmental Framework for Schizophrenia

Biological Psychiatry, Год журнала: 2022, Номер 92(6), С. 491 - 500

Опубликована: Март 14, 2022

Язык: Английский

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Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation

Neuron, Год журнала: 2023, Номер 112(3), С. 421 - 440.e7

Опубликована: Ноя. 17, 2023

Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to protracted timeline of development, which likely does not reach full maturity before end adolescence. However, underlying mechanisms that drive emergence and fine-tuning abilities adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored activity throughout postnatal development mice showed an initial increase was interrupted extensive microglia-mediated breakdown activity, followed rewiring elements achieve adult-like patterns synchrony. Interfering with these processes but adulthood, led a long-lasting microglia-induced disruption neuronal morphology decreased abilities. These results identified nonlinear reorganization circuits adolescence revealed its importance for adult network function processing.

Язык: Английский

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Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities

Current Biology, Год журнала: 2023, Номер 33(20), С. 4353 - 4366.e5

Опубликована: Сен. 19, 2023

The interplay between olfaction and higher cognitive processing has been documented in the adult brain; however, its development is poorly understood. In mice, shortly after birth, endogenous stimulus-evoked activity olfactory bulb (OB) boosts oscillatory entrainment of downstream lateral entorhinal cortex (LEC) hippocampus (HP). However, it unclear whether early OB a long-lasting impact on entorhinal-hippocampal function processing. Here, we chemogenetically silenced synaptic outputs mitral/tufted cells, main projection neurons OB, during postnatal days 8-10. transient manipulation leads to reduction coupling weaker responsiveness stimuli within developing circuits accompanied by dendritic sparsification LEC pyramidal neurons. Moreover, silencing reduces performance behavioral tests involving later life. Thus, neonatal critical for functional LEC-HP maturation abilities.

Язык: Английский

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Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Авг. 5, 2022

Abstract Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells transferred to the fetus. They referred as microchimeric (MMc). Among other organs, MMc seed into fetal brain, where their is unknown. Here, we show that, in offspring’s developing mice, express a unique signature of sensome markers, control microglia homeostasis prevent excessive presynaptic elimination. Further, facilitate oscillatory entrainment prefrontal-hippocampal circuits support maturation behavioral abilities. Our findings highlight that not mere placental leak out, but rather functional mechanism shapes optimal conditions for healthy later life.

Язык: Английский

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Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex

Neuron, Год журнала: 2022, Номер 111(2), С. 256 - 274.e10

Опубликована: Ноя. 28, 2022

Язык: Английский

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Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Фев. 1, 2023

Interneurons are fundamental cells for maintaining the excitation-inhibition balance in brain health and disease. While interneurons have been shown to play a key role pathophysiology of autism spectrum disorder (ASD) adult mice, little is known about how their maturation altered developing striatum ASD. Here, we aimed track striatal elucidate molecular physiological alterations Cntnap2 knockout mouse model. Using Stereo-seq single-cell RNA sequencing data, first characterized pattern expression at embryonic stages medial ganglionic eminence (MGE), transitory structure producing most cortical interneurons. We found that enriched striatum, compared cortex, particularly cholinergic then revealed enhanced MGE-derived cell proliferation, followed by increased loss during canonical window developmental death mice. uncovered specific cellular Lhx6-expressing which impacts interneuron firing properties postnatal week. Overall, our work unveils some mechanisms underlying shift trajectory greatly contribute ASD pathogenesis.

Язык: Английский

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