Influence of claustrum on cortex varies by area, layer, and cell type

Neuron, Год журнала: 2022, Номер 111(2), С. 275 - 290.e5

Опубликована: Ноя. 10, 2022

Язык: Английский

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How deep is the brain? The shallow brain hypothesis

Nature reviews. Neuroscience, Год журнала: 2023, Номер 24(12), С. 778 - 791

Опубликована: Окт. 27, 2023

Язык: Английский

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A role for the claustrum in cognitive control

Trends in Cognitive Sciences, Год журнала: 2022, Номер 26(12), С. 1133 - 1152

Опубликована: Сен. 30, 2022

Язык: Английский

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Pain-induced adaptations in the claustro-cingulate pathway

Cell Reports, Год журнала: 2023, Номер 42(5), С. 112506 - 112506

Опубликована: Май 1, 2023

Persistent pain is a prevalent medical concern correlating with hyperexcitable anterior cingulate cortex (ACC). Its activity modulated by inputs from several brain regions, but the maladjustments that these afferent circuits undergo during transition acute to chronic still require clarification. We focus on ACC-projecting claustrum (CLAACC) neurons and their responses sensory aversive stimuli in mouse model of inflammatory pain. Using chemogenetics, vivo calcium imaging, ex electrophysiological approaches, we reveal suppression CLAACC acutely attenuates allodynia preferentially transmits information ACC. With prolonged pain, claustro-cingulate functional impairment develops, which mediated weakened excitatory drive onto ACC pyramidal neurons, resulting diminished claustral influence These findings support an instrumental role processing nociceptive its susceptibility persistent states.

Язык: Английский

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Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 26, 2024

Abstract The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness stimuli, which spans the axis of engagement. To test hypothesis, we recorded population dynamics from male mice during both sleep an attentional task (‘ENGAGE’). Heightened activity in neurons projecting anterior cingulate cortex (ACCp) corresponded reduced sensory Similarly, ENGAGE task, heightened ACCp correlated with disengagement behavioral lapses, while low hyper-engagement impulsive errors. Chemogenetic elevation awakenings errors task. Furthermore, employing exploration strategy showed stronger correlation between performance compared exploitation complexity. Our results implicate restricting engagement goal-directed behavior.

Язык: Английский

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Single neurons and networks in the claustrum integrate input from widespread cortical sources

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Май 6, 2022

The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet fully explored at level single neurons. Here, we investigated identity, connectivity, and activity identified neurons understand how structure's unique convergence input divergence output support binding information streams. We found that in communicate with each other across efferent projection-defined modules which were differentially innervated by sensory frontal cortical areas. Individual responsive inputs from more than region a cell-type projection-specific manner, particularly between areas cortex. In vivo imaging axons revealed responses both unimodal multimodal stimuli. Finally, chronic silencing specifically reduced animals' sensitivity These findings view fundamentally integrative structure, consolidating around cortex redistributing it following local computations.

Язык: Английский

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The mouse claustrum synaptically connects cortical network motifs

Cell Reports, Год журнала: 2022, Номер 41(12), С. 111860 - 111860

Опубликована: Дек. 1, 2022

Язык: Английский

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Brain-state-dependent constraints on claustrocortical communication and function

Cell Reports, Год журнала: 2023, Номер 43(1), С. 113620 - 113620

Опубликована: Дек. 29, 2023

Neural activity in the claustrum has been associated with a range of vigilance states, yet patterns and efficacy synaptic communication identified neurons have not thoroughly determined. Here, we show that projecting to retrosplenial cortex are most active during synchronized cortical states such as non-rapid eye movement (NREM) sleep suppressed increased desynchronization arousal, movement, REM sleep. The claustrocortical signaling is NREM diminished due part cholinergic tone. Finally, activation enhances memory consolidation through phase resetting delta waves. Therefore, constrained function effectively cognitive processes consolidation.

Язык: Английский

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Claustral neurons projecting to frontal cortex restrict opioid consumption

Current Biology, Год журнала: 2023, Номер 33(13), С. 2761 - 2773.e8

Опубликована: Июнь 27, 2023

The synthetic opioid fentanyl is a major contributor to the current addiction crisis. We report that claustral neurons projecting frontal cortex limit oral self-administration in mice. found transcriptionally activates frontal-projecting claustrum neurons. These also exhibit unique suppression of Ca2+ activity upon initiation bouts consumption. Optogenetic stimulation neurons, intervening this suppression, decreased In contrast, constitutive inhibition context novel, group-housed procedure increased bout This same manipulation sensitized conditioned-place preference for and enhanced representation experience cortex. Together, our results indicate exert inhibitory control over cortical restrict intake. Upregulation claustro-frontal projection may be promising strategy reducing human addiction.

Язык: Английский

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Claustrum projections to the anterior cingulate modulate nociceptive and pain-associated behavior

Current Biology, Год журнала: 2024, Номер 34(9), С. 1987 - 1995.e4

Опубликована: Апрель 12, 2024

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Язык: Английский

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