Cited by eLife assessment: A toolbox for genetic targeting of the claustrum

Influence of claustrum on cortex varies by area, layer, and cell type DOI

Ethan G. McBride, Saurabh R. Gandhi,

Jacqulyn R. Kuyat

et al.

Neuron, Journal Year: 2022, Volume and Issue: 111(2), P. 275 - 290.e5

Published: Nov. 10, 2022

Language: Английский

Citations

A role for the claustrum in cognitive control DOI

Maxwell B. Madden,

Brent W. Stewart, Michael G. White

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(12), P. 1133 - 1152

Published: Sept. 30, 2022

Language: Английский

Citations

How deep is the brain? The shallow brain hypothesis DOI

Mototaka Suzuki, Cyriel M. A. Pennartz, Jaan Aru

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(12), P. 778 - 791

Published: Oct. 27, 2023

Language: Английский

Citations

Pain-induced adaptations in the claustro-cingulate pathway DOI

Niels R. Ntamati, Mario A. Acuña, Thomas Nevian

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(5), P. 112506 - 112506

Published: May 1, 2023

Persistent pain is a prevalent medical concern correlating with hyperexcitable anterior cingulate cortex (ACC). Its activity modulated by inputs from several brain regions, but the maladjustments that these afferent circuits undergo during transition acute to chronic still require clarification. We focus on ACC-projecting claustrum (CLAACC) neurons and their responses sensory aversive stimuli in mouse model of inflammatory pain. Using chemogenetics, vivo calcium imaging, ex electrophysiological approaches, we reveal suppression CLAACC acutely attenuates allodynia preferentially transmits information ACC. With prolonged pain, claustro-cingulate functional impairment develops, which mediated weakened excitatory drive onto ACC pyramidal neurons, resulting diminished claustral influence These findings support an instrumental role processing nociceptive its susceptibility persistent states.

Language: Английский

Citations

Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior DOI

Gal Atlan, Noa Matosevich,

Noa Peretz‐Rivlin

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 26, 2024

Abstract The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness stimuli, which spans the axis of engagement. To test hypothesis, we recorded population dynamics from male mice during both sleep an attentional task (‘ENGAGE’). Heightened activity in neurons projecting anterior cingulate cortex (ACCp) corresponded reduced sensory Similarly, ENGAGE task, heightened ACCp correlated with disengagement behavioral lapses, while low hyper-engagement impulsive errors. Chemogenetic elevation awakenings errors task. Furthermore, employing exploration strategy showed stronger correlation between performance compared exploitation complexity. Our results implicate restricting engagement goal-directed behavior.

Language: Английский

Citations

Single neurons and networks in the claustrum integrate input from widespread cortical sources DOI

Andrew M. Shelton, David K. Oliver,

Ivan P Lazarte

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: May 6, 2022

The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet fully explored at level single neurons. Here, we investigated identity, connectivity, and activity identified neurons understand how structure's unique convergence input divergence output support binding information streams. We found that in communicate with each other across efferent projection-defined modules which were differentially innervated by sensory frontal cortical areas. Individual responsive inputs from more than region a cell-type projection-specific manner, particularly between areas cortex. In vivo imaging axons revealed responses both unimodal multimodal stimuli. Finally, chronic silencing specifically reduced animals' sensitivity These findings view fundamentally integrative structure, consolidating around cortex redistributing it following local computations.

Language: Английский

Citations

The mouse claustrum synaptically connects cortical network motifs DOI

Houman Qadir, Brent W. Stewart, Jonathan W. VanRyzin

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 41(12), P. 111860 - 111860

Published: Dec. 1, 2022

Language: Английский

Citations

Brain-state-dependent constraints on claustrocortical communication and function DOI

Brian A. Marriott,

D. Alison,

Coline Portet

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 43(1), P. 113620 - 113620

Published: Dec. 29, 2023

Neural activity in the claustrum has been associated with a range of vigilance states, yet patterns and efficacy synaptic communication identified neurons have not thoroughly determined. Here, we show that projecting to retrosplenial cortex are most active during synchronized cortical states such as non-rapid eye movement (NREM) sleep suppressed increased desynchronization arousal, movement, REM sleep. The claustrocortical signaling is NREM diminished due part cholinergic tone. Finally, activation enhances memory consolidation through phase resetting delta waves. Therefore, constrained function effectively cognitive processes consolidation.

Language: Английский

Citations

Claustral neurons projecting to frontal cortex restrict opioid consumption DOI

Anna Terem,

Yonatan Fatal,

Noa Peretz‐Rivlin

et al.

Current Biology, Journal Year: 2023, Volume and Issue: 33(13), P. 2761 - 2773.e8

Published: June 27, 2023

The synthetic opioid fentanyl is a major contributor to the current addiction crisis. We report that claustral neurons projecting frontal cortex limit oral self-administration in mice. found transcriptionally activates frontal-projecting claustrum neurons. These also exhibit unique suppression of Ca2+ activity upon initiation bouts consumption. Optogenetic stimulation neurons, intervening this suppression, decreased In contrast, constitutive inhibition context novel, group-housed procedure increased bout This same manipulation sensitized conditioned-place preference for and enhanced representation experience cortex. Together, our results indicate exert inhibitory control over cortical restrict intake. Upregulation claustro-frontal projection may be promising strategy reducing human addiction.

Language: Английский

Citations

Claustrum projections to the anterior cingulate modulate nociceptive and pain-associated behavior DOI

Christian A. Faig,

Gloria Kim,

D. Alison

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(9), P. 1987 - 1995.e4

Published: April 12, 2024

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Language: Английский

Citations