Network state transitions during cortical development

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(8), С. 535 - 552

Опубликована: Май 23, 2024

Язык: Английский

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Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors

Stem Cell Reports, Год журнала: 2025, Номер unknown, С. 102387 - 102387

Опубликована: Янв. 1, 2025

The mechanisms that determine distinct embryonic pallial identities remain elusive. central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show timely inhibition MAPK/ERK and BMP neuralized mouse stem cells (ESCs) specifies a cell identity characteristic allocortex. Comparison global gene expression profiles neural generated by (MiBi cells) with those from early postnatal encephalic regions reveals MiBi cells, isocortical hippocampal cells. display unique pattern connectivity, share molecular electrophysiological features entorhinal cortex. Our results suggest changes can specify fates are maintained specific neuronal lineages independent subsequent morphogenetic interactions their functional connectivity.

Язык: Английский

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Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities

Current Biology, Год журнала: 2023, Номер 33(20), С. 4353 - 4366.e5

Опубликована: Сен. 19, 2023

The interplay between olfaction and higher cognitive processing has been documented in the adult brain; however, its development is poorly understood. In mice, shortly after birth, endogenous stimulus-evoked activity olfactory bulb (OB) boosts oscillatory entrainment of downstream lateral entorhinal cortex (LEC) hippocampus (HP). However, it unclear whether early OB a long-lasting impact on entorhinal-hippocampal function processing. Here, we chemogenetically silenced synaptic outputs mitral/tufted cells, main projection neurons OB, during postnatal days 8-10. transient manipulation leads to reduction coupling weaker responsiveness stimuli within developing circuits accompanied by dendritic sparsification LEC pyramidal neurons. Moreover, silencing reduces performance behavioral tests involving later life. Thus, neonatal critical for functional LEC-HP maturation abilities.

Язык: Английский

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Neuronal coupling modes show differential development in the early cortical activity networks of human newborns

Journal of Neuroscience, Год журнала: 2024, Номер 44(26), С. e1012232024 - e1012232024

Опубликована: Май 20, 2024

The third trimester is a critical period for the development of functional networks that support lifelong neurocognitive performance, yet emergence neuronal coupling in these poorly understood. Here, we used longitudinal high-density electroencephalographic recordings from preterm infants during 33 to 45 weeks conceptional age (CA) characterize early spatiotemporal patterns local cortical function and intrinsic modes [ICMs; phase–phase (PPCs), amplitude–amplitude (AACs), phase–amplitude correlations (PACs)]. Absolute power showed robust increase with CA across full frequency spectrum, while PACs sleep state-specific, biphasic peaked few before normal birth. AACs distant decreased globally at nearly all frequencies. In contrast, PPCs frequency- region-selective development, an strength between frontal, central, occipital regions low-delta alpha frequencies together wider-spread decrease other Our findings present spectrally spatially differential distinct ICMs neonatal provide their developmental templates future basic clinical research.

Язык: Английский

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Developmental changes in brain-wide fear memory networks

Neurobiology of Learning and Memory, Год журнала: 2025, Номер unknown, С. 108037 - 108037

Опубликована: Март 1, 2025

Memory retrieval involves coordinated activity across multiple brain regions. Yet how the organization of memory networks evolves throughout development remains poorly understood. In this study, we compared whole-brain functional that are active during contextual fear recall in infant, juvenile, and adult mice. Our analyses revealed long-term change significantly postnatal development. Infant dense heterogeneous, whereas sparse have a small-world topology. While hippocampal subregions were highly connected nodes at all ages, cortex gained many connections Different matured different rates, but their developmental timing fell into three major categories: stepwise between two linear or inverted-U, with elevated connectivity juveniles. work highlights subset regions likely maintain important roles encoding, undergoes significant reorganization Together, these results provide blueprint for studying correlated cellular key areas distinctly regulates storage

Язык: Английский

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Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation-induced cognitive impairment in mice

Neuropharmacology, Год журнала: 2024, Номер 262, С. 110205 - 110205

Опубликована: Ноя. 2, 2024

Язык: Английский

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The evolving neurobiology of early-life stress

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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cFOS as a biomarker of activity maturation in the hippocampal formation

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июль 13, 2023

We explored the potential for cFOS expression as a marker of functional development “resting-state” waking activity in extended network hippocampus and entorhinal cortex. examined sleeping awake mice at (P)ostnatal days 5, 9, 13, 17 well adulthood. find that is state-dependent even 5 old, with reliable staining occurring only mice. Even during waking, was rare weak P5. The septal nuclei, cortex layer (L)2, anterodorsal thalamus were exceptional they had robust P5 similar to or greater than Significant also observed dentate gyrus, L6, postsubiculum L4-6, ventral subiculum, supramammillary nucleus, posterior hypothalamic nucleus. these regions grew stronger age, new added progressively P9 P13 by which point overall pattern many qualitatively adult. Six regions—CA1, dorsal L2-3, reuniens perirhinal postrhinal cortices—were very late developing, mostly achieving adult levels after P17. Our findings support number developmental principles. First, early spontaneous patterns induced muscle twitches sleep do not induce hippocampal network. Second, follows progressive activation along trisynaptic circuit, rather birth date cellular maturation. Third, we reveal components egocentric head-direction theta-rhythm circuits earliest active forebrain. results suggest may provide sensitive biomarker formation development, particularly regard attainment normal state synchronizing rhythms such theta gamma.

Язык: Английский

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Hippocampal CA1 pyramidal cells do not receive monosynaptic input from thalamic nucleus reuniens

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Окт. 1, 2021

Abstract The prefrontal – hippocampal entorhinal system is perhaps the most widely-studied circuit in cognitive and systems neuroscience, due to its role supporting functions such as working memory decision-making. Disrupted communication within this a key feature of disorders schizophrenia dementia. Nucleus reuniens (NRe) midline thalamic nucleus that sits at nexus circuit, linking these regions together. As there are no direct projections from cortex hippocampus, accepted model NRe mediates drive activity, although connections poorly defined cellular synaptic level. Using ex vivo optogenetics electrophysiology, alongside monosynaptic circuit-tracing, we sought test mechanisms through which could activity. Unexpectedly, found evidence pyramidal cells CA1 receive input NRe, with hippocampus proper appearing selective for GABAergic interneurons. In other targeted by prosubiculum subiculum received inputs were least an order magnitude weaker than those or cortices. We conclude that, contrary widely-held assumptions field, not major target reuniens.

Язык: Английский

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