bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
Abstract
The
globus
pallidus
externa
(GPe)
is
a
heterogenous
nucleus
of
the
basal
ganglia,
with
intricate
connections
to
other
ganglia
nuclei,
as
well
direct
cortex.
anatomic,
molecular
and
electrophysiologic
properties
cortex-projecting
pallidocortical
neurons
are
not
characterized.
Here
we
show
that
project
diverse
motor
non-motor
cortical
regions,
organized
topographically
in
GPe,
segregate
into
two
distinct
electrophysiological
phenotypes.
In
addition,
find
GPe
receives
synaptic
input
back
from
deep
layers
some
which
form
reciprocal
onto
neurons.
These
results
demonstrate
existence
fast,
closed-loop
circuit
between
cortex
ideally
positioned
integrate
information
about
behavioral
goals,
internal
states,
environmental
cues
rapidly
modulate
behavior.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Hydrogels
are
emerging
as
promising
candidates
for
brain–computer
interfaces.
This
review
highlights
the
current
advancements
in
implantable
hydrogel
electrodes
neural
signal
recording,
neuromodulation,
and
brain
disorder
treatment.
Current Opinion in Neurobiology,
Год журнала:
2023,
Номер
83, С. 102798 - 102798
Опубликована: Окт. 30, 2023
The
degeneration
of
mesencephalic
dopaminergic
neurons
that
innervate
the
basal
ganglia
is
responsible
for
cardinal
motor
symptoms
Parkinson's
disease
(PD).
It
has
been
thought
loss
signaling
in
one
region
-
striatum
was
solely
network
pathophysiology
causing
PD
symptoms.
While
our
understanding
dopamine
(DA)'s
role
modulating
striatal
circuitry
deepened
recent
years,
it
also
become
clear
acts
other
regions
to
influence
movement.
Underscoring
this
point,
examination
a
new
progressive
mouse
model
shows
DA
depletion
alone
not
sufficient
induce
parkinsonism
and
restoration
extra-striatal
attenuates
parkinsonian
deficits
once
they
appear.
This
review
summarizes
advances
effort
understand
circuitry,
its
modulation
by
DA,
how
dysfunction
drives
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Ноя. 9, 2023
Abstract
The
auditory
striatum,
a
sensory
portion
of
the
dorsal
plays
an
essential
role
in
learning
and
memory.
In
contrast
to
its
roles
underlying
mechanisms
operant
conditioning,
however,
little
is
known
about
contribution
classical
fear
conditioning.
Here,
we
reveal
function
striatum
auditory-conditioned
We
find
that
optogenetically
inhibiting
striatal
neurons
impairs
memory
formation,
which
mediated
through
striatal-amygdala
pathway.
Using
calcium
imaging
behaving
mice,
neuronal
responses
conditioned
tones
potentiate
across
acquisition
expression.
Furthermore,
nigrostriatal
dopaminergic
projections
important
modulating
conditioning-induced
potentiation.
Together,
these
findings
demonstrate
existence
nigro-striatal-amygdala
circuit
for
formation
Authorea (Authorea),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 13, 2024
For
decades
the
external
globus
pallidus
(GPe)
has
been
viewed
as
a
passive
way-station
in
indirect
pathway
of
cortico-basal
ganglia-thalamic
(CBGT)
circuit,
sandwiched
between
striatal
inputs
and
basal
ganglia
outputs.
According
to
this
model,
one-way
descending
signals
amplify
suppression
downstream
thalamic
nuclei
by
inhibiting
GPe
activity.
Here
we
revisit
assumption,
light
new
emerging
work
on
cellular
complexity,
connectivity,
functional
role
behavior.
We
show
how,
according
circuit-level
logic,
is
ideally
positioned
for
relaying
ascending
control
within
ganglia.
Focusing
problem
inhibitory
control,
illustrate
how
bidirectional
flow
information
allows
integration
reactive
proactive
mechanisms
during
action
selection.
Taken
together,
evidence
points
being
central
hub
CBGT
participating
linking
multifaceted
regulate
European Journal of Neuroscience,
Год журнала:
2024,
Номер
60(9), С. 6129 - 6144
Опубликована: Апрель 24, 2024
Abstract
For
decades,
the
external
globus
pallidus
(GPe)
has
been
viewed
as
a
passive
way‐station
in
indirect
pathway
of
cortico‐basal
ganglia‐thalamic
(CBGT)
circuit,
sandwiched
between
striatal
inputs
and
basal
ganglia
outputs.
According
to
this
model,
one‐way
descending
signals
amplify
suppression
downstream
thalamic
nuclei
by
inhibiting
GPe
activity.
Here,
we
revisit
assumption,
light
new
emerging
work
on
cellular
complexity,
connectivity
functional
role
behaviour.
We
show
how,
according
circuit‐level
logic,
is
ideally
positioned
for
relaying
ascending
control
within
ganglia.
Focusing
problem
inhibitory
control,
illustrate
how
bidirectional
flow
information
allows
integration
reactive
proactive
mechanisms
during
action
selection.
Taken
together,
evidence
points
being
central
hub
CBGT
participating
linking
multifaceted
regulate
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Behavioral
flexibility
allows
animals
to
adjust
actions
changing
environments.
While
the
basal
ganglia
are
critical
for
adaptation,
specific
role
of
external
globus
pallidus
(GPe)
is
unclear.
This
study
examined
contributions
two
major
GPe
cell
types-prototypic
neurons
projecting
subthalamic
nucleus
(Proto
GPe→STN
neurons)
and
astrocytes-to
behavioral
flexibility.
Using
longitudinal
operant
conditioning
with
context
reversals,
we
found
that
Proto
dynamically
represent
contextual
information
correlating
optimality.
In
contrast,
astrocytes
exhibited
gradual
encoding
independent
performance.
Deleting
impaired
adaptive
responses
action-outcome
contingencies
without
altering
initial
reward-seeking
acquisition,
highlighting
their
in
enabling
Furthermore,
discovered
integrate
inhibitory
striatal
excitatory
inputs,
modulating
downstream
circuits
support
flexible
behavior.
research
elucidates
complementary
roles
cellular
mechanisms
Annual Review of Neuroscience,
Год журнала:
2024,
Номер
47(1), С. 63 - 83
Опубликована: Март 1, 2024
Deep
brain
stimulation
(DBS),
a
method
in
which
electrical
is
delivered
to
specific
areas
of
the
brain,
an
effective
treatment
for
managing
symptoms
number
neurological
and
neuropsychiatric
disorders.
Clinical
access
neural
circuits
during
DBS
provides
opportunity
study
functional
link
between
behavior.
This
review
discusses
how
use
Parkinson's
disease
dystonia
has
provided
insights
into
networks
physiological
mechanisms
that
underlie
motor
control.
In
parallel,
from
basic
science
about
patterns
impact
plasticity
communication
within
are
transforming
therapy
treating
circuits,
with
goal
training
out
its
diseased
state.
