Projections between the globus pallidus externa and cortex span motor and non-motor regions DOI Open Access

Emily Ferenczi,

Wei Wang, Abhishek Biswas

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The globus pallidus externa (GPe) is a heterogenous nucleus of the basal ganglia, with intricate connections to other ganglia nuclei, as well direct cortex. anatomic, molecular and electrophysiologic properties cortex-projecting pallidocortical neurons are not characterized. Here we show that project diverse motor non-motor cortical regions, organized topographically in GPe, segregate into two distinct electrophysiological phenotypes. In addition, find GPe receives synaptic input back from deep layers some which form reciprocal onto neurons. These results demonstrate existence fast, closed-loop circuit between cortex ideally positioned integrate information about behavioral goals, internal states, environmental cues rapidly modulate behavior.

Language: Английский

Implantable hydrogels as pioneering materials for next-generation brain–computer interfaces DOI
Wasid Ullah Khan,

Zhenzhen Shen,

Samuel M. Mugo

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Hydrogels are emerging as promising candidates for brain–computer interfaces. This review highlights the current advancements in implantable hydrogel electrodes neural signal recording, neuromodulation, and brain disorder treatment.

Language: Английский

Citations

1
Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs DOI
Patricia Bonnavion, Christophe Varin, Gohar Fakhfouri

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(9), P. 1783 - 1793

Published: July 4, 2024

Language: Английский

Citations

7
Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease DOI Creative Commons
Shenyu Zhai, Qiaoling Cui, DeNard V. Simmons

et al.

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 83, P. 102798 - 102798

Published: Oct. 30, 2023

The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia is responsible for cardinal motor symptoms Parkinson's disease (PD). It has been thought loss signaling in one region - striatum was solely network pathophysiology causing PD symptoms. While our understanding dopamine (DA)'s role modulating striatal circuitry deepened recent years, it also become clear acts other regions to influence movement. Underscoring this point, examination a new progressive mouse model shows DA depletion alone not sufficient induce parkinsonism and restoration extra-striatal attenuates parkinsonian deficits once they appear. This review summarizes advances effort understand circuitry, its modulation by DA, how dysfunction drives

Language: Английский

Citations

15
Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning DOI Creative Commons
Allen P. F. Chen, Lu Chen, Kaiyo W. Shi

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 9, 2023

Abstract The auditory striatum, a sensory portion of the dorsal plays an essential role in learning and memory. In contrast to its roles underlying mechanisms operant conditioning, however, little is known about contribution classical fear conditioning. Here, we reveal function striatum auditory-conditioned We find that optogenetically inhibiting striatal neurons impairs memory formation, which mediated through striatal-amygdala pathway. Using calcium imaging behaving mice, neuronal responses conditioned tones potentiate across acquisition expression. Furthermore, nigrostriatal dopaminergic projections important modulating conditioning-induced potentiation. Together, these findings demonstrate existence nigro-striatal-amygdala circuit for formation

Language: Английский

Citations

14
Rethinking the external globus pallidus and information flow in cortico-basal ganglia-thalamic circuits DOI Open Access
Cristina Giossi, Jonathan Rubin, Aryn H. Gittis

et al.

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: April 13, 2024

For decades the external globus pallidus (GPe) has been viewed as a passive way-station in indirect pathway of cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to this model, one-way descending signals amplify suppression downstream thalamic nuclei by inhibiting GPe activity. Here we revisit assumption, light new emerging work on cellular complexity, connectivity, functional role behavior. We show how, according circuit-level logic, is ideally positioned for relaying ascending control within ganglia. Focusing problem inhibitory control, illustrate how bidirectional flow information allows integration reactive proactive mechanisms during action selection. Taken together, evidence points being central hub CBGT participating linking multifaceted regulate

Language: Английский

Citations

4
Rethinking the external globus pallidus and information flow in cortico‐basal ganglia‐thalamic circuits DOI Creative Commons
Cristina Giossi, Jonathan Rubin, Aryn H. Gittis

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(9), P. 6129 - 6144

Published: April 24, 2024

Abstract For decades, the external globus pallidus (GPe) has been viewed as a passive way‐station in indirect pathway of cortico‐basal ganglia‐thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to this model, one‐way descending signals amplify suppression downstream thalamic nuclei by inhibiting GPe activity. Here, we revisit assumption, light new emerging work on cellular complexity, connectivity functional role behaviour. We show how, according circuit‐level logic, is ideally positioned for relaying ascending control within ganglia. Focusing problem inhibitory control, illustrate how bidirectional flow information allows integration reactive proactive mechanisms during action selection. Taken together, evidence points being central hub CBGT participating linking multifaceted regulate

Language: Английский

Citations

4
Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors DOI Creative Commons
Shinwoo Kang, Minsu Abel Yang,

Aubrey Bennett

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Behavioral flexibility allows animals to adjust actions changing environments. While the basal ganglia are critical for adaptation, specific role of external globus pallidus (GPe) is unclear. This study examined contributions two major GPe cell types-prototypic neurons projecting subthalamic nucleus (Proto GPe→STN neurons) and astrocytes-to behavioral flexibility. Using longitudinal operant conditioning with context reversals, we found that Proto dynamically represent contextual information correlating optimality. In contrast, astrocytes exhibited gradual encoding independent performance. Deleting impaired adaptive responses action-outcome contingencies without altering initial reward-seeking acquisition, highlighting their in enabling Furthermore, discovered integrate inhibitory striatal excitatory inputs, modulating downstream circuits support flexible behavior. research elucidates complementary roles cellular mechanisms

Language: Английский

Citations

0
What Are Current Concepts on the Functional Organization of the Globus Pallidus Externus and Its Potential Role in Parkinson Disease? DOI
Eduardo E. Benarroch

Neurology, Journal Year: 2025, Volume and Issue: 104(10)

Published: May 6, 2025

Language: Английский

Citations

0
From avoidance to new action: the multifaceted role of the striatal indirect pathway DOI
Jaeeon Lee, Bernardo L. Sabatini

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

Citations

0
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control DOI
Aryn H. Gittis, Roy V. Sillitoe

Annual Review of Neuroscience, Journal Year: 2024, Volume and Issue: 47(1), P. 63 - 83

Published: March 1, 2024

Deep brain stimulation (DBS), a method in which electrical is delivered to specific areas of the brain, an effective treatment for managing symptoms number neurological and neuropsychiatric disorders. Clinical access neural circuits during DBS provides opportunity study functional link between behavior. This review discusses how use Parkinson's disease dystonia has provided insights into networks physiological mechanisms that underlie motor control. In parallel, from basic science about patterns impact plasticity communication within are transforming therapy treating circuits, with goal training out its diseased state.

Language: Английский

Citations

3