Expert Review of Clinical Immunology,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Окт. 23, 2024
Introduction
Postpartum
mood
disorders
are
heterogenous
and
comprise
postpartum
psychosis
depression.
Evidence
is
accumulating
that
systemic
monocyte/macrophage
activation,
low
grade
inflammation
(premature
senescence
related)
T
cell
defects
increase
the
risk
for
outside
pregnancy
by
affecting
function
of
microglia
cells
in
emotional
brain
(the
cortico-limbic
system)
leading
to
inadequate
regulation
upon
stress.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5846 - 5846
Опубликована: Май 28, 2024
The
circadian
clock
regulates
biological
cycles
across
species
and
is
crucial
for
physiological
activities
biochemical
reactions,
including
cancer
onset
development.
interplay
between
the
rhythm
involves
regulating
cell
division,
DNA
repair,
immune
function,
hormonal
balance,
potential
chronotherapy.
This
highlights
importance
of
maintaining
a
healthy
prevention
treatment.
article
investigates
complex
relationship
cancer,
exploring
how
disruptions
to
internal
may
contribute
tumorigenesis
influence
progression.
Numerous
databases
are
utilized
conduct
searches
articles,
such
as
NCBI,
MEDLINE,
Scopus.
keywords
used
throughout
academic
archives
“circadian
rhythm”,
”cancer”,
”circadian
clock”.
Maintaining
cycle
prioritizing
sleep
habits
minimizing
disruptions,
consistent
schedules,
reduced
artificial
light
exposure,
meal
timing
adjustments.
Dysregulation
gene
can
cause
tumor
growth,
leading
need
regulate
better
treatment
outcomes.
components
significantly
impact
cellular
responses
damage,
influencing
Understanding
rhythm’s
role
in
diseases
their
therapeutic
targets
essential
treating
preventing
cancer.
Disruptions
promote
abnormal
development
metastasis,
potentially
due
system
imbalances
fluctuations.
Cell Stress,
Год журнала:
2024,
Номер
8, С. 21 - 50
Опубликована: Янв. 1, 2024
The
eight
biological
hallmarks
of
health
that
we
initially
postulated
(Cell.
2021
Jan
7;184(1):33-63)
include
features
spatial
compartmentalization
(integrity
barriers,
containment
local
perturbations),
maintenance
homeostasis
over
time
(recycling
&
turnover,
integration
circuitries,
rhythmic
oscillations)
and
an
array
adequate
responses
to
stress
(homeostatic
resilience,
hormetic
regulation,
repair
regeneration).
These
affect
all
somatic
strata
the
human
body
(molecules,
organelles,
cells,
supracellular
units,
organs,
organ
systems,
systemic
circuitries
meta-organism).
Here
postulate
mental
socioeconomic
factors
must
be
added
this
8×8
matrix
as
additional
hallmark
(“psychosocial
adaptation”)
stratum
interactions”),
hence
building
a
9×9
matrix.
Potentially,
perturbation
each
affects
psychosocial
vice
versa.
Finally,
discuss
(patho)physiological
bases
these
interactions
their
implications
for
improvement.
Neuropsychopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
Bipolar
disorder
(BD)
is
a
severe
psychiatric
characterized
by
alternating
manic
and
depressive
episodes.
The
molecular
mechanisms
underlying
the
transition
between
mania
depression
remain
unclear.
Utilizing
animal
model
induced
ouabain,
we
observed
reduced
phosphorylated
level
of
cyclic
AMP-responsive
element-binding
protein
(pCREB)
Period
(PER)2
expression
in
cornu
ammonis
(CA1)
region
hippocampus,
which
were
restored
lithium
treatment.
shRNA
knockdown
CREB
or
Per2
CA1
mania-like
behavior,
while
overexpression
both
factors
resulted
depression-like
behavior.
Furthermore,
our
analyses
revealed
that
upregulation
downregulation
influenced
each
other’s
expression.
Co-immunoprecipitation
results
demonstrated
interacts
with
PER2.
Taken
together,
data
suggest
for
potential
inter-regulatory
crosstalk
CREB–PER2
hippocampal
region,
mediates
mania-
behaviors.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 352 - 352
Опубликована: Март 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Abstract
Light
is
a
crucial
environmental
factor
that
influences
various
aspects
of
life,
including
physiological
and
psychological
processes.
While
light
well-known
for
its
role
in
enabling
humans
other
animals
to
perceive
their
surroundings,
influence
extends
beyond
vision.
Importantly,
affects
our
internal
time-keeping
system,
the
circadian
clock,
which
regulates
daily
rhythms
biochemical
processes,
ultimately
impacting
mood
behaviour.
The
24-h
availability
can
have
profound
effects
on
well-being,
both
physically
mentally,
as
seen
cases
jet
lag
shift
work.
This
review
summarizes
intricate
relationships
between
light,
mood-related
behaviours,
exploring
underlying
mechanisms
implications
health.
Translational Psychiatry,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 21, 2025
The
circadian
rhythm
system
consists
of
a
master
clock
located
in
the
suprachiasmatic
nucleus
(SCN)
hypothalamus
and
peripheral
clocks
dispersed
throughout
other
brain
areas
(including
striatum,
Str)
as
well
various
tissues
organs.
Circadian
disturbance
is
major
risk
factor
common
comorbidity
for
mood
disorders,
especially
anxiety
depression.
Bmal1
one
fundamental
protein
genes
that
required
to
maintain
rhythm.
Recent
research
has
revealed
link
between
dysfunction
depression,
but
underlying
mechanisms
remain
be
fully
elucidated.
This
study
aimed
investigate
how
may
lead
anxiety-
depression-like
behaviors.
Through
behavioral
tests,
virus
tracing,
molecular
biology
techniques,
we
found
neural
connection
from
striatum.
SCN
lesions
Bmal1flox/flox
+
pAAV-hSyn-Cre-GFP
(conditional
knockout,
cKO)
mice
exhibited
disruptions
core
body
temperature
rhythm,
Importantly,
these
displayed
altered
expression
patterns
an
upregulation
Brain-Derived
Neurotrophic
Factor
(BDNF)
-
Tyrosine
Kinase
receptor
B
(TrkB)
signaling
pathway
within
Microinjection
TrkB
inhibitor
ANA-12
can
effectively
reverse
These
findings
indicate
contribute
pathogenesis
depression
through
BDNF-TrkB
potentially
mediated
by
projections
SCN.
gene
represent
novel
therapeutic
target
disorders.
