Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Язык: Английский

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Hippocampal transcriptome analysis in ClockΔ19 mice identifies pathways associated with glial cell differentiation and myelination

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Correlation Between Monocyte Count, Monocyte–Lymphocyte Ratio, and Other Inflammatory Cells With Sleep and Psychiatric Symptoms in First-Episode Schizophrenia Patients

Neuropsychiatric Disease and Treatment, Год журнала: 2025, Номер Volume 21, С. 373 - 381

Опубликована: Фев. 1, 2025

More and more evidence shows that infection immune abnormality are closely related to the increased severity of schizophrenia symptoms. This study aimed explore correlation between inflammatory cell counts, sleep quality, psychiatric symptoms in first-episode patients. A total 103 patients (patient group) admitted Anhui Provincial Mental Health Center from November 2021 August 2022 were included study, while 57 healthy individuals (control who met criteria recruited as subjects. The Positive Negative Symptom Scale (PANSS) Pittsburgh Sleep Quality Index (PSQI) used evaluate mental status Blood analysis results determine peripheral blood white cells (WBC) lymphocytes two groups. Count neutrophils, monocytes, platelets (PLT) neutrophil lymphocyte ratio (NLR), monocyte (MLR), platelet (PLR) calculated. Differential, correlation, regression performed on survey data using SPSS 26.0. Results showed WBC, NLR, MLR higher case vs control group (p<0.05). Correlation found monocytes negatively correlated with time (rs=-0.205, p=0.037) arousal factor (rs=-0.204, p=0.039). Linear positively affected score (B=7.196, t=2.781, p=0.006) (B=-0.851, t=-2.157, p=0.033). ROC revealed high sensitivity specificity for SCZ symptom prediction. concluded elevated levels significantly associated symptoms, particularly affecting factors, demonstrated predictive validity

Язык: Английский

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Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats

Behavioral and Brain Functions, Год журнала: 2025, Номер 21(1)

Опубликована: Фев. 28, 2025

Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male animals, neglecting potential between sexes. This study aims to investigate sex-specific function under sleep using reward-based operant conditioning tasks. Sprague-Dawley rats were pre-trained on a lever-press task and subsequently divided into control chronic restriction (CSR) groups. The CSR group underwent 14 days of restriction. After modeling, assessed the open field test, retraining lever-pressing task, signal discrimination extinction evaluate motor abilities, memory formation, learning, flexibility. impaired performance both sexes, with requiring more time exhibiting lower accuracy. In showed longer feeding latency accuracy compared females. also specifically increased frequency responses rats. enhanced exploration females higher frequencies than males. Biochemically, induced alterations, including elevated serum MDA MAO levels males serotonin, dopamine, epinephrine Although activation was observed metabolites tryptophan-kynurenine pathway, evident kynurenic acid metabolism prefrontal cortex. female rats, significant observed. Male exhibited discrimination, while learning These accompanied by CSR-induced oxidative stress, neurotransmitter dysregulation, disturbances tryptophan metabolic pathway. findings underscore importance considering understanding effects developing targeted intervention strategies.

Язык: Английский

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Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117994 - 117994

Опубликована: Март 1, 2025

Fenvalerate, a typical pyrethroid pesticide, is neurological toxicant. This study aimed to evaluate the effect of paternal exposure fenvalerate on depressive-like behaviours in adolescent offspring. Depression-like behavior was determined by Sucrose Preference Test (SPT), Tail Suspension (TST) and Forced Swimming (FST) The level dopamine reduced midbrain fenvalerate-exposed Tyrosine hydroxylase (Th), rate limiting enzyme for synthesis, significantly offspring exposed fenvalerate. And Th decreased hindbrain fetuses Transcriptome analysis revealed growth factor receptor-bound protein 10 (Grb10) fetal Grb10 mRNA were Interestingly, vitro experiments, si-Grb10. Conversely, increased oe-Grb10. Mechanistically, 5mC content gene at one CpG fragment eighteen sites sperm In summary, causes altering DNA methylation sperm.

Язык: Английский

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Sleep Disorders: Pathogenesis and Therapeutic Interventions

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Март 1, 2025

Sleep disorder significantly disrupts the quality of life for patients. Although it is clinically acknowledged, fundamental neuropathological mechanisms are still not understood. Recent preclinical research has been directed toward understanding underlying sleep deprivation and sleep/wake dysregulation. linked to changes in structure function neural basis cognition. We reviewed circuits related disorders, along with alterations connectivity brain region functions, based on advancements electrophysiology optogenetic/chemogenetic techniques. subsequently outline cellular molecular modifications disorders studies, primarily involving neuronal metabolism, electrophysiological activity, synaptic plasticity, glial cells. Correspondingly, crosstalk between peripheral organs, we elucidate involvement celiac disease hepatic pathogenesis disorders. In this review, mainly discussed at molecular, cellular, circuit levels that contribute disorder. The review also covered potential strategies treating future avenues.

Язык: Английский

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The role of TRPV4 in acute sleep deprivation-induced memory impairment: mechanisms of calcium dysregulation and synaptic plasticity disruption

Cell Insight, Год журнала: 2025, Номер unknown, С. 100240 - 100240

Опубликована: Март 1, 2025

Acute sleep deprivation (ASD) impairs memory formation, but the underlying mechanisms remain unclear. In this study, we employed an ASD model combined with fear conditioning to investigate these mechanisms. mRNA sequencing revealed upregulated expression of Transient Receptor Potential Vanilloid 4 (TRPV4), a nonselective Ca2+-permeable cation channel critical for calcium signaling, in mice ASD-induced impairments. Notably, TRPV4 knockdown reversed deficits. was associated increased intracellular Ca2+ concentrations, reduced spine density, and decreased postsynaptic density protein 95 (PSD95), key regulator synaptic plasticity. These findings suggest that may cause overload, leading disrupted plasticity impaired learning memory. Importantly, significantly mitigated impairments, contributed restoration. Together, demonstrate protective role against deficits highlight as potential therapeutic target impairment ASD.

Язык: Английский

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Imaging Probes for the Detection of Brain Microenvironment

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114677 - 114677

Опубликована: Апрель 1, 2025

Язык: Английский

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LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Abstract Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors are highly expressed the striatum. Significant side effects haloperidol, known as extrapyramidal symptoms, lead motor deficits similar those seen Parkinson’s disease and present a major challenge clinical settings. The underlying molecular responsible for these remain poorly understood. disease-associated leucine-rich repeat kinase 2 (LRRK2) has an essential role striatal physiology link receptor signaling. Here, we systematically explore convergent signaling haloperidol LRRK2 pharmacological or genetic inhibition kinase, well knock-in mouse models expressing pathogenic mutant with increased activity. Behavioral assays show ameliorates haloperidol-induced changes mice. A combination electrophysiological anatomical approaches reveals interferes changes, specifically neurons indirect pathway. Proteomic studies targeted intracellular pathway analyses demonstrate induces pattern Our study suggests plays key undesirable haloperidol. This work opens up new therapeutic avenues dopamine-related disorders, such psychosis, also furthering our understanding pathophysiology.

Язык: Английский

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Therapeutic sleep deprivation for major depressive disorder: A randomized controlled trial

Journal of Affective Disorders, Год журнала: 2024, Номер 361, С. 10 - 16

Опубликована: Июнь 4, 2024

Язык: Английский

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