Dopamine release after acute sleep deprivation: culprit of affective state transitions DOI Creative Commons

Ju Lan,

Zhong Chen, Heming Cheng

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: July 1, 2024

Affective disorder is a prevalent chronic mental illness characterized by episodes of mania, depression, or alternating recurrent both. It associated with high suicide rate and low diagnosis rate, leading to severe functional impairments. The disruption sleep rhythm significant contributing factor in affective state transitions, but the underlying cellular neural circuit mechanisms remain poorly understood. In recent publication, Wu et al. developed an innovative mouse model automatic deprivation, unveiling that acute deprivation (SD) leads abnormal excitability distinct dopaminergic (DAergic) subsystems, thereby triggering transition manic-like reversal depression-like mice.1 Firstly, established SD integrating elevated platform rotating beam, effectively reducing both non-rapid eye movement rapid mice while minimizing stress compulsive motion (Figure 1A).1 They found normal exhibited heightened levels hyperactivity, aggression, sexual behavior following 12 h SD. However, this phenomenon reverted basal within 24–48 h, which highly likely restoration sleep-wake warrants further verification. addition, significantly ameliorated behaviors induced learned helplessness mice. Interestingly, antidepressant effect was sustained for at least 72 aligned clinical test.2 These findings indicate can induce hyperactive transformation reverse DAergic nervous system, as vital component ascending reticular plays crucial role essential physiological functions such regulation, emotional modulation, motor coordination.3 Moreover, alterations function circuits contribute various disorders including depression mania.4 precise mechanism system implicated disturbance be elucidated. Using calcium fiber photometry, observed remarkable increase activity neurons ventral tegmental area (VTA) during SD.1 Chemogenetic inhibition VTA not only reversed SD-induced hyperactivity aggressive also reduced attenuation depressive having no on behavior. suggest induces increased neurons, Increasing evidence indicates systems via downstream circuits. To investigate transmission different brain regions, used dopamine sensors monitor release nucleus accumbens (NAc), medial prefrontal cortex (mPFC), hypothalamus (HA), dorsal striatum (dStr).1 During SD, content NAc, mPFC, HA, change detected dStr. applied circuit-specific modulation evaluate their functions. Selectively VTA-NAc increases locomotion, selective VTA-mPFC effects. Intriguingly, VTA-HA counteracted elevation behavior, whereas VTA-dStr did exert any influence these aforementioned behaviors. demonstrate are mediated subsystems project targets. Furthermore, except dopamine, neuromodulators histamine serotonin play pivotal waking-promoting intricately involved regulation emotion. Therefore, investigating contribution transitions equally imperative. Alterations neuroplasticity mPFC closely depression. previously demonstrated ketamine enhances hyperplasia dendritic spines pyramidal receptor D1 (Drd1) receptors, exerting effects.5 wonder if results effects through similar mechanisms. By using Thy1-EGFP mice, they density deep 24 immediate enhancement probability glutamate-induced regeneration after Besides, conditional knockout Drd1 alteration spine regeneration. receptor-dependent neuronal plasticity mPFC. end, genetically encoded photoactivatable Rac1 (PaRac1) selectively eliminate recently activated synapses activating PaRac1 required Overall, mediates spines. inhibiting neonatal suggesting existence alternative conclusion, study demonstrates transmissions contributes diverse SD-associated 1B,C). addition affecting states, impact other cognition memory. This explore Ju Lan Heming Cheng wrote manuscript prepared figure. Zhong Chen provided valuable discussion modified manuscript. All authors have read approved final We appreciate Professor Yi Wang his support study. work supported National Natural Science Foundation China (82204353) Zhejiang Provincial (LY24H310002). declare conflict interest. Not applicable.

Language: Английский

Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment DOI Creative Commons

Qibo Huang,

Bai Hu,

Zhang Ping

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Language: Английский

Citations

2
Hippocampal transcriptome analysis in ClockΔ19 mice identifies pathways associated with glial cell differentiation and myelination DOI
Yingying Wei, Liansheng Zhao, Jinxue Wei

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Correlation Between Monocyte Count, Monocyte–Lymphocyte Ratio, and Other Inflammatory Cells With Sleep and Psychiatric Symptoms in First-Episode Schizophrenia Patients DOI Creative Commons
Chen Hu, Nan Du, Jingwei Li

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 373 - 381

Published: Feb. 1, 2025

More and more evidence shows that infection immune abnormality are closely related to the increased severity of schizophrenia symptoms. This study aimed explore correlation between inflammatory cell counts, sleep quality, psychiatric symptoms in first-episode patients. A total 103 patients (patient group) admitted Anhui Provincial Mental Health Center from November 2021 August 2022 were included study, while 57 healthy individuals (control who met criteria recruited as subjects. The Positive Negative Symptom Scale (PANSS) Pittsburgh Sleep Quality Index (PSQI) used evaluate mental status Blood analysis results determine peripheral blood white cells (WBC) lymphocytes two groups. Count neutrophils, monocytes, platelets (PLT) neutrophil lymphocyte ratio (NLR), monocyte (MLR), platelet (PLR) calculated. Differential, correlation, regression performed on survey data using SPSS 26.0. Results showed WBC, NLR, MLR higher case vs control group (p<0.05). Correlation found monocytes negatively correlated with time (rs=-0.205, p=0.037) arousal factor (rs=-0.204, p=0.039). Linear positively affected score (B=7.196, t=2.781, p=0.006) (B=-0.851, t=-2.157, p=0.033). ROC revealed high sensitivity specificity for SCZ symptom prediction. concluded elevated levels significantly associated symptoms, particularly affecting factors, demonstrated predictive validity

Language: Английский

Citations

0
Sex differences in reward-based operant conditioning performance and neurotransmitter changes following chronic sleep restriction stress in rats DOI Creative Commons
Yiwen Zhang, Fang Chen,

Muhan Yu

et al.

Behavioral and Brain Functions, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 28, 2025

Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male animals, neglecting potential between sexes. This study aims to investigate sex-specific function under sleep using reward-based operant conditioning tasks. Sprague-Dawley rats were pre-trained on a lever-press task and subsequently divided into control chronic restriction (CSR) groups. The CSR group underwent 14 days of restriction. After modeling, assessed the open field test, retraining lever-pressing task, signal discrimination extinction evaluate motor abilities, memory formation, learning, flexibility. impaired performance both sexes, with requiring more time exhibiting lower accuracy. In showed longer feeding latency accuracy compared females. also specifically increased frequency responses rats. enhanced exploration females higher frequencies than males. Biochemically, induced alterations, including elevated serum MDA MAO levels males serotonin, dopamine, epinephrine Although activation was observed metabolites tryptophan-kynurenine pathway, evident kynurenic acid metabolism prefrontal cortex. female rats, significant observed. Male exhibited discrimination, while learning These accompanied by CSR-induced oxidative stress, neurotransmitter dysregulation, disturbances tryptophan metabolic pathway. findings underscore importance considering understanding effects developing targeted intervention strategies.

Language: Английский

Citations

0
Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring DOI Creative Commons
Huiru Chen, Tao Wang, Jing Shao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117994 - 117994

Published: March 1, 2025

Fenvalerate, a typical pyrethroid pesticide, is neurological toxicant. This study aimed to evaluate the effect of paternal exposure fenvalerate on depressive-like behaviours in adolescent offspring. Depression-like behavior was determined by Sucrose Preference Test (SPT), Tail Suspension (TST) and Forced Swimming (FST) The level dopamine reduced midbrain fenvalerate-exposed Tyrosine hydroxylase (Th), rate limiting enzyme for synthesis, significantly offspring exposed fenvalerate. And Th decreased hindbrain fetuses Transcriptome analysis revealed growth factor receptor-bound protein 10 (Grb10) fetal Grb10 mRNA were Interestingly, vitro experiments, si-Grb10. Conversely, increased oe-Grb10. Mechanistically, 5mC content gene at one CpG fragment eighteen sites sperm In summary, causes altering DNA methylation sperm.

Language: Английский

Citations

0
Sleep Disorders: Pathogenesis and Therapeutic Interventions DOI Creative Commons

Cheng Liu,

Zhigang He,

Yanqiong Wu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Sleep disorder significantly disrupts the quality of life for patients. Although it is clinically acknowledged, fundamental neuropathological mechanisms are still not understood. Recent preclinical research has been directed toward understanding underlying sleep deprivation and sleep/wake dysregulation. linked to changes in structure function neural basis cognition. We reviewed circuits related disorders, along with alterations connectivity brain region functions, based on advancements electrophysiology optogenetic/chemogenetic techniques. subsequently outline cellular molecular modifications disorders studies, primarily involving neuronal metabolism, electrophysiological activity, synaptic plasticity, glial cells. Correspondingly, crosstalk between peripheral organs, we elucidate involvement celiac disease hepatic pathogenesis disorders. In this review, mainly discussed at molecular, cellular, circuit levels that contribute disorder. The review also covered potential strategies treating future avenues.

Language: Английский

Citations

0
The role of TRPV4 in acute sleep deprivation-induced memory impairment: mechanisms of calcium dysregulation and synaptic plasticity disruption DOI Creative Commons

Meimei Guo,

Feiyang Zhang,

Sha Liu

et al.

Cell Insight, Journal Year: 2025, Volume and Issue: unknown, P. 100240 - 100240

Published: March 1, 2025

Acute sleep deprivation (ASD) impairs memory formation, but the underlying mechanisms remain unclear. In this study, we employed an ASD model combined with fear conditioning to investigate these mechanisms. mRNA sequencing revealed upregulated expression of Transient Receptor Potential Vanilloid 4 (TRPV4), a nonselective Ca2+-permeable cation channel critical for calcium signaling, in mice ASD-induced impairments. Notably, TRPV4 knockdown reversed deficits. was associated increased intracellular Ca2+ concentrations, reduced spine density, and decreased postsynaptic density protein 95 (PSD95), key regulator synaptic plasticity. These findings suggest that may cause overload, leading disrupted plasticity impaired learning memory. Importantly, significantly mitigated impairments, contributed restoration. Together, demonstrate protective role against deficits highlight as potential therapeutic target impairment ASD.

Language: Английский

Citations

0
Imaging Probes for the Detection of Brain Microenvironment DOI
Shiming Zhang, Tianyu Wang,

Tianzi Gao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114677 - 114677

Published: April 1, 2025

Language: Английский

Citations

0
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons DOI Creative Commons
Chuyu Chen, Meghan Masotti, Nathaniel Shepard

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors are highly expressed the striatum. Significant side effects haloperidol, known as extrapyramidal symptoms, lead motor deficits similar those seen Parkinson’s disease and present a major challenge clinical settings. The underlying molecular responsible for these remain poorly understood. disease-associated leucine-rich repeat kinase 2 (LRRK2) has an essential role striatal physiology link receptor signaling. Here, we systematically explore convergent signaling haloperidol LRRK2 pharmacological or genetic inhibition kinase, well knock-in mouse models expressing pathogenic mutant with increased activity. Behavioral assays show ameliorates haloperidol-induced changes mice. A combination electrophysiological anatomical approaches reveals interferes changes, specifically neurons indirect pathway. Proteomic studies targeted intracellular pathway analyses demonstrate induces pattern Our study suggests plays key undesirable haloperidol. This work opens up new therapeutic avenues dopamine-related disorders, such psychosis, also furthering our understanding pathophysiology.

Language: Английский

Citations

0
Therapeutic sleep deprivation for major depressive disorder: A randomized controlled trial DOI

Yahui Xu,

Fang Wu, Shuai Yu

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 361, P. 10 - 16

Published: June 4, 2024

Language: Английский

Citations

3