BMJ Open,
Год журнала:
2024,
Номер
14(11), С. e087684 - e087684
Опубликована: Ноя. 1, 2024
Introduction
The
gut
microbiome
plays
an
important
role
in
maintaining
both
cognitive
and
physical
functions
older
adults,
dysbiosis
is
pathophysiological
mechanism
of
mild
impairment
(MCI)
adults.
As
a
typical
traditional
Chinese
mind-body
exercise,
regular
Baduanjin
training
has
been
shown
to
improve
function
modulate
the
community-dwelling
However,
potential
benefits
on
remains
unclear.
aim
this
study
investigate
mediating
effect
between
improvement
adults
with
MCI.
Methods
analysis
This
two-arm,
randomised,
parallel-controlled,
single-blinded
trial.
Four
residential
communities
(clusters)
total
64
eligible
participants
(16
each
community)
will
be
randomised
1:1
either
24-week
exercise
intervention
group
(60
min
per
session,
four
sessions
week)
or
no
specific
control
group.
Global
subdimensions
cognition
including
executive
function,
visuospatial
language
memory
assessed
using
Montreal
Cognitive
Assessment
Scale,
Trail
Making
Test,
Auditory
Verbal
Learning
Boston
Naming
Test-30
Clock-Drawing
while
its
metabolomics
detected
16S
rRNA
ultra-high-performance
liquid
chromatography–tandem
mass
spectrometry
at
baseline
end
intervention.
microbiota
analysed
linear
mixed
models
bootstrapping
method
Hayes
process.
Ethics
dissemination
conforms
Declaration
Helsinki
principles
relevant
ethical
guidelines.
Ethical
approval
obtained
from
Committee
Shanghai
University
Medicine
Health
Sciences
(approval
number:
2023-GZR-011).
Written
informed
consent
all
participants.
Results
disseminated
groups
peer-reviewed
journal(s),
international
national
scientific
conferences.
Key
findings
also
shared
social
media,
healthcare
providers,
support
access
for
non-research
audiences.
Trial
registration
number
ChiCTR2300078147.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 3010 - 3010
Опубликована: Март 5, 2024
This
systematic
review
addresses
the
use
of
Lactiplantibacillus
(Lactobacillus)
plantarum
in
symptomatological
intervention
neurodegenerative
disease.
The
existence
gut
microbiota
dysbiosis
has
been
associated
with
systemic
inflammatory
processes
present
disease,
creating
opportunity
for
new
treatment
strategies.
involves
modifying
strains
that
constitute
to
enhance
synaptic
function
through
gut–brain
axis.
Recent
studies
have
evaluated
beneficial
effects
on
motor
and
cognitive
symptomatology,
alone
or
combination.
includes
20
research
articles
(n
=
3
human
n
17
animal
models).
main
result
this
was
combination
produced
improvements
symptomatology
related
However,
one
included
reported
negative
after
administration
plantarum.
provides
current
relevant
information
about
probiotic
pathologies
such
as
Alzheimer’s
Parkinson’s
disease
Multiple
Sclerosis.
Neuropharmacology,
Год журнала:
2025,
Номер
unknown, С. 110322 - 110322
Опубликована: Янв. 1, 2025
Personality
disorders
(PDs)
are
psychiatric
conditions
characterized
by
enduring
patterns
of
cognition,
emotion,
and
behaviour
that
deviate
significantly
from
cultural
norms,
causing
distress
or
impairment.
The
aetiology
PDs
is
complex,
involving
both
genetic
environmental
factors.
Genetic
studies
estimate
the
heritability
at
30%
to
60%,
implicating
genes
involved
in
neurotransmitter
regulation,
such
as
those
for
serotonin
transporters
dopamine
receptors.
Environmental
factors,
including
childhood
trauma
chronic
stress,
interact
with
predispositions
induce
epigenetic
modifications
like
DNA
methylation
histone
modifications,
contributing
PD
development.
Neurobiological
research
has
identified
structural
functional
abnormalities
brain
regions
related
emotional
regulation
social
amygdala,
prefrontal
cortex,
limbic
system.
These
linked
impaired
emotion
processing
interpersonal
functioning
PDs.
This
review
focuses
on
how
factors
shape
maladaptive
behaviours
endophenotypes
central
many
It
explores
interaction
between
Ras-ERK,
p38,
mTOR
molecular
pathways
response
stimuli,
examines
role
oxidative
stress
mitochondrial
metabolism
these
processes.
Also
reviewed
various
types
existing
animal
models
replicate
key
endophenotypes,
highlighting
changes
neurotransmitters
neurohormones.
Identifying
biomarkers
can
lead
development
"enviromimetic"
drugs,
which
mimic
influences
activate
pathways,
facilitating
targeted,
personalized
treatments
based
profiles
individuals
Ultimately,
understanding
mechanisms
promises
enhance
diagnostic
accuracy,
prognosis,
therapeutic
outcomes
affected
individuals.
Food Bioengineering,
Год журнала:
2024,
Номер
3(1), С. 126 - 147
Опубликована: Март 1, 2024
Abstract
The
establishment
of
a
healthy
microbiota,
particularly
during
infancy,
profoundly
influences
psychological
health
and
neurological
function
through
the
gut‐brain
axis.
This
review
delves
into
intricate
connections
between
probiotics,
gut
microbiome
development,
their
impact
on
disorders.
Biotics,
live
microorganisms
with
proven
benefits,
have
emerged
as
promising
intervention,
critical
developmental
stages.
Administering
specific
probiotic
strains
(
Lactobacillus
species
Bifidobacterium
)
in
infancy
has
shown
promise
preventing
alleviating
disorders,
implications
for
well‐being.
bidirectional
communication
along
axis
underscores
potential
probiotics
influencing
outcomes,
ranging
from
anxiety
to
neurodevelopmental
Additionally,
this
explores
emerging
food
engineering
techniques
(microencapsulation,
genome
editing,
fermentation,
protein
engineering,
immobilization,
etc.)
employed
preparing
probiotic‐based
foods,
ensuring
viability
targeted
release
gastrointestinal
tract.
BMC Gastroenterology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 20, 2025
Gastrointestinal
disorders
(GIDs)
in
the
elderly
often
lead
to
impaired
gastric
motility
and
nutrient
absorption,
exacerbating
malnutrition.
Probiotics,
particularly
Lactobacillus
rhamnosus
GG
(LGG),
may
enhance
absorption.
This
study
evaluates
impact
of
LGG
supplementation
on
absorption
patients
with
GIDs.
A
retrospective
analysis
was
conducted
231
GIDs,
divided
into
a
probiotic
(PS)
group
(n
=
110)
NPS
121).
The
PS
received
(1
×
1010
CFU,
twice
daily)
for
at
least
7
days.
Baseline
post-treatment
measurements
included
via
ultrasonography,
gastrointestinal
hormone
levels
using
radioimmunoassay,
markers
through
ELISA
calorimetry.
Post-treatment,
exhibited
significantly
improved
motility,
increased
antral
contraction
amplitude
(58.65
mm
vs.
56.53
mm;
P
0.004),
frequency
(4.06
3.81
times/min;
0.009),
reduced
half-emptying
time
(28.15
min
29.77
min;
0.007).
Hormone
analyses
showed
elevated
motilin
neuropeptide
Y
decreased
vasoactive
intestinal
peptide
(P
<
0.05).
Nutrient
indicated
stool
fat,
protein,
carbohydrate
content,
enhanced
permeability,
weight
digestibility
energy,
protein
enhances
indicating
potential
therapeutic
benefits
addressing
digestive
dysfunction
malnutrition
this
demographic.
Complementary Therapies in Medicine,
Год журнала:
2024,
Номер
82, С. 103045 - 103045
Опубликована: Май 4, 2024
This
study
aimed
to
evaluate
the
clinical
efficacy
and
safety
of
probiotics
supplementation
in
treatment
Parkinson's
disease
(PD).
We
searched
China
National
Knowledge
Infrastructure
(CNKI),
Weipu
(VIP)
database,
Wanfang
Database,
Sinomed
(CBM),
PubMed,
Embase,
Cochrane
library
Web
Science
databases
for
eligible
studies
from
inception
January
4th,
2024.
Randomized
controlled
trials
(RCTS)
comparing
effects
probiotic
supplements
placebo
patients
with
PD.
Meta-analysis
was
conducted
software
Review
Manager
5.4.
The
quality
assessment
performed
according
risk
bias
tool.
A
total
11
RCTs
756
PD
were
included
this
study.
found
that
could
increase
number
complete
bowel
movements
(CBMs)
per
week
improved
scores
Patient
Assessment
Constipation
Quality
Life
Questionnaire
(PAC-QOL)
(SMD
=
0.73,
95%
CI:
0.54
-
0.92,
P
<
0.00001,
I2
45%;
SMD
-0.79,
-1.19
-0.39,
0.001,
55%,
respectively)
compared
group.
However,
there
no
significant
difference
between
two
groups
improving
fecal
traits
defecation
efforts
0.87,
0.01
1.74,
0.05,
94%;
1.24,
-1.58
4.06,
>
98%,
respectively).
In
terms
composite
scale
scores:
after
treatment,
Movement
Disorder
Society-Unified-Parkinson
Disease
Rating
Scale
Ⅲ
score
(MDS-UPDRSⅢ)
group
-0.09,
-0.35
0.16,
0%).
conclusion,
based
on
overall
results
available
studies,
our
suggested
potential
value
constipation
symptoms
patients.
Therefore,
may
be
one
adjuvant
therapy
PD-related
findings
provide
more
proof
supporting
effectiveness
probiotics,
encouraging
utilized
alone
or
combination
other
therapies
practice
well-designed
large
sample
sizes
are
required.
Prolonged
and
intense
physical
activity
can
trigger
stress
response
mechanisms
across
various
physiological
systems-including
the
cardiovascular,
respiratory,
gastrointestinal,
musculoskeletal,
neuroendocrine
systems-disrupting
energy
metabolism,
immune
function,
redox
balance,
hormonal
regulation.
Critically,
when
not
accompanied
by
adequate
recovery,
such
exertion
may
impair
rather
than
enhance
athletic
performance.
In
parallel,
there
has
been
growing
interest
in
probiotics
as
natural,
safe,
accessible
dietary
supplements
with
potential
to
support
performance
recovery.
Emerging
evidence
highlights
pivotal
role
of
gut
microbiome
mediating
communication
along
gut-brain
gut-muscle
axes,
thereby
influencing
only
metabolic
functions
but
also
neuromuscular
adaptation
fatigue
resistance.
This
review
explores
through
which
exercise
performance,
mitigate
exercise-induced
fatigue,
improve
via
modulation
inflammation,
oxidative
stress,
signaling
pathways.
Framed
within
context
predictive,
preventive,
personalized
medicine
(3P
medicine),
this
paper
emphasizes
diagnostic
therapeutic
probiotic
strategies
optimizing
qualitative
quantitative
assessment
microbiota
host
responses.
