International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16416 - 16416
Опубликована: Ноя. 16, 2023
Understanding
the
neurobiological
underpinnings
of
depressive
disorder
constitutes
a
pressing
challenge
in
fields
psychiatry
and
neurobiology.
Depression
represents
one
most
prevalent
forms
mental
behavioral
disorders
globally.
Alterations
dimerization
capacity
can
influence
functional
characteristics
serotonin
receptors
may
constitute
contributing
factor
to
onset
disorders.
The
objective
this
review
is
consolidate
current
understanding
interactions
within
5-HT
receptor
family
between
members
other
families.
Furthermore,
it
aims
elucidate
role
such
complexes
delineate
mechanisms
through
which
antidepressants
exert
their
effects.
Molecules,
Год журнала:
2018,
Номер
23(4), С. 940 - 940
Опубликована: Апрель 17, 2018
Panax
notoginseng
(Burk)
F.
H.
Chen,
as
traditional
Chinese
medicine,
has
a
long
history
of
high
clinical
value,
such
anti-inflammatory,
anti-oxidation,
inhibition
platelet
aggregation,
regulation
blood
glucose
and
pressure,
neuronal
apoptosis,
protection,
its
main
ingredients
are
saponins
(PNS).
Currently,
Chen
may
improve
mental
function,
have
anti-insomnia
anti-depression
effects,
alleviate
anxiety,
decrease
neural
network
excitation.
However,
the
underlying
effects
mechanisms
containing
chemical
constituents
(PNS)
on
these
depression-related
or
anxiety-related
diseases
not
been
completely
established.
This
review
summarized
antidepressant
anxiolytic
PNS
analyzed
targets
actions
with
pharmacology
tools
to
provide
directions
references
for
further
pharmacological
studies
new
ideas
treatment
nervous
system
drug
development.
The
showed
components
exert
through
regulating
neurotransmitter
mechanism
(5-HT,
DA,
NE),
modulation
gamma-amino
butyric
acid
(GABA)
neurotransmission,
glutamatergic
system,
hypo-thalamus-pituitary-adrenal
(HPA)
axis,
brain-derived
neurotrophic
factor
(BDNF),
intracellular
signaling
pathways
in
central
system;
produce
protection
by
aggregation
pathways.
Network
target
analysis
indicated
also
anti-inflammatory
anti-apoptotic
which
leads
preservation
brain
nerves,
regulate
activity
secretion
nerve
cells,
exerting
in-depth
researches
related
mechanisms.
BioMed Research International,
Год журнала:
2018,
Номер
2018, С. 1 - 11
Опубликована: Янв. 1, 2018
Ginseng
is
a
traditional
Chinese
medicine
with
wide
range
of
pharmacological
activities.
Ginsenosides
are
the
major
constituents
ginseng.
have
unique
biological
activity
and
medicinal
value,
such
as
antitumor,
anti-inflammatory,
antioxidation,
inhibition
cell
apoptosis.
With
increase
stress
in
life,
incidence
nervous
system
diseases
also
increasing.
Neurological
pose
huge
burden
on
people’s
life
health.
In
recent
years,
some
studies
shown
that
ginsenosides
certain
role
prevention
treatment
neurological
diseases.
However,
research
still
its
infancy,
relevant
mechanisms
complex.
paper,
we
review
effects
epilepsy,
depression,
cerebral
ischemia
reperfusion
injury,
Alzheimer’s
disease,
Parkinson’s
disease.
We
hope
to
provide
theoretical
basis
for
by
ginsenosides.
Frontiers in Immunology,
Год журнала:
2018,
Номер
9
Опубликована: Дек. 7, 2018
Depression
is
considered
a
neuropsychiatric
disease
associated
with
various
neuronal
changes
within
specific
brain
regions.
We
previously
reported
that
ginsenoside-Rg1,
potential
neuroprotective
agent
extracted
from
ginseng,
significantly
alleviated
depressive-like
disorders
induced
by
chronic
stress
in
rats.
However,
the
mechanisms
which
ginsenoside-Rg1
exerts
its
effects
depression
remain
largely
uncharacterized.
In
present
study
we
confirm
prevented
antidepressant-like
rat
model
of
unpredictable
mild
(CUMS)
and
report
on
some
underlying
this
effect.
Specifically,
found
pretreatment
prior
to
exposure
suppressed
inflammatory
pathway
activity
via
alleviating
overexpression
proinflammatory
cytokines
activation
microglia
astrocytes.
These
were
accompanied
an
attenuation
dendritic
spine
synaptic
deficits
as
upregulation
synaptic-related
proteins
ventral
medial
prefrontal
cortex
(vmPFC).
addition,
inhibited
apoptosis
CUMS
exposure,
increased
Bcl-2
expression
decreased
cleaved
Caspase-3
Caspase-9
vmPFC
region.
Furthermore,
could
increase
nuclear
factor
erythroid
2-related
(Nrf2)
inhibit
p38
mitogen-activated
protein
kinase
(p-p38
MAPK)
κB
(NF-κB)
p65
subunit
vmPFC.
Taken
together,
these
results
suggest
may
assume
effect
animal
depression,
appears
result
amelioration
CUMS-dependent
deterioration
Moreover,
they
also
provide
support
for
therapeutic
treatment
stress-related
mental
disorders.
Cell Proliferation,
Год журнала:
2019,
Номер
52(6)
Опубликована: Окт. 10, 2019
Abstract
Objectives
Panax
ginseng,
a
well‐known
traditional
Chinese
medicine
with
multiple
pharmacological
activities,
plays
crucial
role
in
modulating
mood
disorders.
Several
recent
studies
have
identified
an
underlying
of
ginseng
the
prevention
and
treatment
depression.
However,
cellular
molecular
mechanisms
remain
unclear.
Materials
Methods
In
this
review,
we
summarized
progress
antidepressant
effects
its
representative
herbal
formulae.
Results
The
formulae
include
monoamine
neurotransmitter
system,
upregulating
expression
neurotrophic
factors,
regulating
function
HPA
axis,
anti‐inflammatory
action.
Conclusions
Therefore,
review
may
provide
theoretical
bases
clinical
applications
for
depression
by
Journal of Ethnopharmacology,
Год журнала:
2020,
Номер
263, С. 112792 - 112792
Опубликована: Апрель 18, 2020
Panax
L.
(Araliaceae)
is
globally-recognized
plant
resource
suitable
for
the
globalization
of
traditional
Chinese
medicines.
It
has
traditionally
been
used
as
tonic
agents
in
various
ethnomedicinal
systems
East
Asia,
especially
China.
often
to
regulate
bodily
functions
and
considered
adjuvant
therapy
tumor,
resuscitation
traumatic
hemorrhagic
shock,
etc.
This
review
systematically
summarized
information
on
distributions,
botanical
characteristics,
uses,
chemical
components
biological
activities
genus
Panax,
order
explore
exploit
therapeutic
potential
this
plant.
The
available
about
was
collected
via
online
search
Web
Science,
Google
Scholar,
PubMed,
Baidu
Science
Direct,
China
National
Knowledge
Infrastructure
Springer
search.
keywords
include
saponin,
secondary
metabolites,
components,
activity,
pharmacology,
medicinal
safety
other
related
words.
Plant
List
(www.theplantlist.org)
Catalogue
Life:
2019
Annual
Checklist
(www.catalogueoflife.org/col/)
databases
were
provide
scientific
names,
subspecies
classification
distribution
Panax.
widely
assessed
concerning
its
phytochemistry
activities.
To
date,
at
least
748
compounds
from
isolated,
including
saponins,
flavonoids,
polysaccharides,
steroids
phenols.
Among
them,
triterpenoid
saponins
polysaccharides
representative
active
ingredients
plants,
which
have
investigated.
Modern
pharmacological
studies
showed
that
these
exhibited
a
wide
range
vitro
vivo
antineoplastic,
anti-inflammatory,
hepatorenal
protective,
neuroprotective,
immunoregulatory,
cardioprotective
antidiabetic
Many
also
confirmed
mechanisms
organ-protective
closely
molecular
signaling
pathways,
expression
proteins
antioxidant
reactions.
sum
up,
high
social
value,
deserving
further
investigation.
very
promising
be
fully
utilized
development
nutraceutical
pharmaceutical
products.
However,
there
lack
in-depth
uses
plants.
In
addition,
single
component
should
performed
based
diversity
structure,
significant
clinical
application.
If
bioactive
molecules
multicomponent
interactions
are
discovered,
it
will
great
significance
application
an
urgent
requirement
carry
out
detailed
phytochemical,
pharmacology
research
classical
prescriptions
establishment
modern
medication
guidelines.
Exploring
basis
herbal
synergistic
actions
may
new
understanding
complex
disease
accelerate
process
development.
Frontiers in Pharmacology,
Год журнала:
2020,
Номер
11
Опубликована: Май 7, 2020
Depression
is
a
multigenetic
or
multifactorial
syndrome.
The
central
neuron
system
(CNS)-orientated,
single
target,
and
conventional
antidepressants
are
insufficient
far
from
ideal.
Traditional
Chinese
Medicine
(TCM)
has
historically
been
used
to
treat
depression
up
till
today,
particularly
in
Asia.
Its
holistic,
multi-drug,
multi-target
nature
fits
well
with
the
therapeutic
idea
of
systems
medicine
treatment.
Over
past
two
decades,
although
efforts
have
made
understand
TCM
herbal
at
molecular
level,
many
fundamental
questions
regarding
their
mechanisms
action
remain
be
addressed
level
order
better
complicated
formulations
In
this
Mini
Review,
we
review
discuss
acting
targets
pathological
brain,
such
as
monoamine
neurotransmissions,
hypothalamic–pituitary–adrenal
(HPA)
axis,
neurotropic
factor
BDNF
cascade,
glutamate
transmission.
Some
molecules,
constituents,
formulas
highlighted
examples
discussed
future
directions
for
comprehensive
researches
level.
Furthermore,
pharmacological
approaches
integration
mechanism
into
understanding
pharmacology
formulations.
Integration
studies
not
only
represents
trend
study
but
also
promotes
our
systemwide
antidepressant
